Incidental Mutation 'IGL02349:Gpr132'
ID289421
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr132
Ensembl Gene ENSMUSG00000021298
Gene NameG protein-coupled receptor 132
SynonymsG2a, G2 accumulation
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02349
Quality Score
Status
Chromosome12
Chromosomal Location112850873-112868228 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 112852855 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Cysteine at position 117 (Y117C)
Ref Sequence ENSEMBL: ENSMUSP00000021729 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021729] [ENSMUST00000222776]
Predicted Effect probably damaging
Transcript: ENSMUST00000021729
AA Change: Y117C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000021729
Gene: ENSMUSG00000021298
AA Change: Y117C

DomainStartEndE-ValueType
low complexity region 33 52 N/A INTRINSIC
Pfam:7tm_1 56 306 6.1e-33 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000222776
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein was reported to be a receptor for lysophosphatidylcholine action, but PubMedID: 15653487 retracts this finding and instead suggests this protein to be an effector of lysophosphatidylcholine action. This protein may have proton-sensing activity and may be a receptor for oxidized free fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
PHENOTYPE: Mice homozygous for disruptions in this gene display a generally normal phenotype but eventually develop a "late onset lymphoproliferative autoimmune syndrome" [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb8 A G 5: 24,406,464 I484V probably benign Het
Acly C T 11: 100,519,679 E158K probably benign Het
Akap3 T A 6: 126,860,263 D3E probably benign Het
Alg8 A G 7: 97,379,894 N152S possibly damaging Het
Ano7 A G 1: 93,391,490 T323A probably benign Het
Bmp1 T C 14: 70,507,549 Y252C possibly damaging Het
Cacnb3 A T 15: 98,640,961 K159* probably null Het
Capns2 T A 8: 92,902,062 V193D probably benign Het
Cct2 A G 10: 117,053,139 I48T probably benign Het
Cep152 A G 2: 125,594,956 S555P probably damaging Het
Col5a3 T C 9: 20,772,361 E1533G unknown Het
Cyp17a1 A G 19: 46,667,497 L451P probably damaging Het
D1Ertd622e A G 1: 97,646,052 L96P probably damaging Het
Dgcr8 T C 16: 18,280,306 E407G possibly damaging Het
Dhx57 T A 17: 80,255,571 N876Y probably damaging Het
Dnah7b T A 1: 46,099,503 L235* probably null Het
Fgfr2 A G 7: 130,242,606 Y50H probably damaging Het
Gars T A 6: 55,048,064 probably benign Het
Gfpt2 A T 11: 49,807,703 I42F probably benign Het
Glcci1 A G 6: 8,558,581 K35E probably damaging Het
Gpatch1 T A 7: 35,307,255 M163L probably damaging Het
Ints1 G A 5: 139,768,468 P650S probably damaging Het
Itga2b T C 11: 102,461,363 D464G probably damaging Het
Kansl2 C A 15: 98,529,446 G185C probably damaging Het
Kat6b T A 14: 21,637,593 M570K probably damaging Het
Map3k19 T A 1: 127,823,769 D615V possibly damaging Het
Map3k7cl A G 16: 87,556,013 probably benign Het
Msto1 A C 3: 88,910,898 S360R possibly damaging Het
Myo15b C A 11: 115,863,105 probably benign Het
Nhlrc2 T C 19: 56,591,719 V428A possibly damaging Het
Olfr33 G A 7: 102,714,126 R96C probably damaging Het
Olfr348 A C 2: 36,787,046 T174P possibly damaging Het
Olfr470 A G 7: 107,845,605 S43P probably benign Het
Olfr568 A T 7: 102,877,909 Y263F probably benign Het
Olfr61 T C 7: 140,638,471 F257L probably benign Het
Olfr874 T A 9: 37,746,206 M24K probably benign Het
Pcm1 G T 8: 41,288,155 probably null Het
Plekhg3 A T 12: 76,562,300 N149I probably damaging Het
Rbp3 C A 14: 33,955,719 H541Q probably damaging Het
Rgp1 T C 4: 43,581,236 probably null Het
Scyl2 A T 10: 89,657,938 probably benign Het
Tas2r144 A C 6: 42,216,076 H250P probably benign Het
Tmppe T C 9: 114,405,200 V189A probably benign Het
Trp53bp1 G A 2: 121,199,074 S1875L probably damaging Het
Txnl4a T A 18: 80,218,729 L60H probably damaging Het
Upp2 A G 2: 58,777,886 D217G probably benign Het
Vmn2r74 A G 7: 85,952,516 L638P probably damaging Het
Vnn1 A G 10: 23,898,503 N148S possibly damaging Het
Xrcc1 C T 7: 24,567,042 Q241* probably null Het
Zfp990 A G 4: 145,530,877 probably benign Het
Other mutations in Gpr132
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1454:Gpr132 UTSW 12 112852240 missense possibly damaging 0.78
R1785:Gpr132 UTSW 12 112852403 missense probably damaging 1.00
R1786:Gpr132 UTSW 12 112852403 missense probably damaging 1.00
R2133:Gpr132 UTSW 12 112852403 missense probably damaging 1.00
R3899:Gpr132 UTSW 12 112852108 missense probably benign 0.05
R3913:Gpr132 UTSW 12 112853020 missense probably benign 0.03
R5226:Gpr132 UTSW 12 112852148 missense probably benign 0.00
R5662:Gpr132 UTSW 12 112852796 missense probably damaging 1.00
R5665:Gpr132 UTSW 12 112852796 missense probably damaging 1.00
R5805:Gpr132 UTSW 12 112852796 missense probably damaging 1.00
R5807:Gpr132 UTSW 12 112852796 missense probably damaging 1.00
R5907:Gpr132 UTSW 12 112852097 missense probably benign
R6902:Gpr132 UTSW 12 112852210 missense probably benign 0.39
R6946:Gpr132 UTSW 12 112852210 missense probably benign 0.39
R7218:Gpr132 UTSW 12 112852429 missense probably damaging 1.00
R7543:Gpr132 UTSW 12 112852202 missense probably benign 0.00
Posted On2015-04-16