Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02351:Trim34a'

289480

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trim34a

Ensembl Gene

ENSMUSG00000056144

Gene Name

tripartite motif-containing 34A

Synonyms

Trim34-1, Trim34

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.119) question?

Stock #

IGL02351

Quality Score

Status

Chromosome

Chromosomal Location

104244457-104262234 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 104261234 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 414 (C414*)

Ref Sequence

ENSEMBL: ENSMUSP00000102462 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000051795] [ENSMUST00000060315] [ENSMUST00000098179] [ENSMUST00000106848] [ENSMUST00000106849]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000051795

SMART Domains

Protein: ENSMUSP00000050084
Gene: ENSMUSG00000060441

Domain	Start	End	E-Value	Type
RING	15	58	3.64e-7	SMART
BBOX	91	132	4.83e-12	SMART
coiled coil region	172	232	N/A	INTRINSIC
Pfam:SPRY	349	485	9.2e-22	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000060315
AA Change: C414*

SMART Domains

Protein: ENSMUSP00000055058
Gene: ENSMUSG00000056144
AA Change: C414*

Domain	Start	End	E-Value	Type
RING	15	58	6.79e-7	SMART
BBOX	91	132	1.08e-9	SMART
coiled coil region	194	238	N/A	INTRINSIC
Blast:PRY	299	343	2e-21	BLAST
Pfam:SPRY	347	474	1e-12	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000098179

SMART Domains

Protein: ENSMUSP00000095781
Gene: ENSMUSG00000060441

Domain	Start	End	E-Value	Type
RING	15	58	3.64e-7	SMART
BBOX	91	132	4.83e-12	SMART
Pfam:SPRY	351	493	1.6e-13	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000106848
AA Change: C414*

SMART Domains

Protein: ENSMUSP00000102461
Gene: ENSMUSG00000056144
AA Change: C414*

Domain	Start	End	E-Value	Type
RING	15	58	6.79e-7	SMART
BBOX	91	132	1.08e-9	SMART
coiled coil region	194	238	N/A	INTRINSIC
Blast:PRY	299	343	2e-21	BLAST
Pfam:SPRY	345	484	6.5e-21	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000106849
AA Change: C414*

SMART Domains

Protein: ENSMUSP00000102462
Gene: ENSMUSG00000056144
AA Change: C414*

Domain	Start	End	E-Value	Type
RING	15	58	6.79e-7	SMART
BBOX	91	132	1.08e-9	SMART
coiled coil region	194	238	N/A	INTRINSIC
Blast:PRY	299	343	2e-21	BLAST
Pfam:SPRY	345	484	6.5e-21	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000158033

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000217156

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abi3bp	A	G	16: 56,654,055	T448A	possibly damaging	Het
Adamtsl1	T	A	4: 86,156,873		probably null	Het
Adgra3	A	G	5: 50,058,558	V73A	probably benign	Het
Aggf1	T	C	13: 95,352,850		probably benign	Het
Aktip	C	T	8: 91,126,892	V96I	possibly damaging	Het
Atm	A	G	9: 53,522,176	I258T	probably benign	Het
Baz1b	C	T	5: 135,244,306	T1428I	probably damaging	Het
C3ar1	A	T	6: 122,849,975	Y428N	probably damaging	Het
C87499	A	T	4: 88,627,890	I405N	probably damaging	Het
Cadps	A	G	14: 12,597,380	S437P	probably damaging	Het
Car4	C	T	11: 84,965,767	P294S	probably damaging	Het
Cbwd1	A	T	19: 24,931,662		probably null	Het
Cenpq	A	G	17: 40,924,332	L213P	probably damaging	Het
Cept1	A	G	3: 106,539,188		probably null	Het
Cln6	A	G	9: 62,847,125	I150V	probably benign	Het
Cyb5r3	T	C	15: 83,160,935	T94A	probably benign	Het
Cyp2c67	A	G	19: 39,617,417	M345T	probably damaging	Het
Dapk2	T	A	9: 66,246,523	I187N	probably damaging	Het
Dkk2	A	G	3: 132,177,912	D191G	probably benign	Het
Dnah8	T	A	17: 30,767,811	F3145I	probably damaging	Het
Dock1	A	C	7: 135,108,819	D1190A	possibly damaging	Het
Ehhadh	T	A	16: 21,762,870	L457F	probably damaging	Het
Ercc6l2	T	C	13: 63,853,683	L552P	probably damaging	Het
Ghrhr	T	G	6: 55,384,153	I284S	probably damaging	Het
Gm10288	A	T	3: 146,839,199		noncoding transcript	Het
Gp6	T	G	7: 4,394,508	I19L	probably benign	Het
Gria4	G	A	9: 4,456,206	S698L	possibly damaging	Het
Ifng	A	T	10: 118,442,505	I53F	possibly damaging	Het
Kazn	A	C	4: 142,147,016		probably null	Het
Khk	A	T	5: 30,928,504	I136F	probably damaging	Het
Lnx1	T	A	5: 74,627,366	N98Y	probably damaging	Het
Lsp1	T	C	7: 142,488,942		probably null	Het
Lta4h	A	T	10: 93,478,467	N467I	probably benign	Het
Mcmbp	C	A	7: 128,709,781		probably null	Het
Me2	A	T	18: 73,797,967	I85K	probably benign	Het
Muc4	C	T	16: 32,750,986	T288I	possibly damaging	Het
Nadsyn1	A	T	7: 143,799,912	Y525N	probably damaging	Het
Nt5e	G	A	9: 88,327,893	V70M	probably damaging	Het
Olfr677	G	A	7: 105,056,975	G243D	probably damaging	Het
Olfr827	T	G	10: 130,210,734	Y132S	probably damaging	Het
Olfr883	A	T	9: 38,026,036	I77L	possibly damaging	Het
Pkd1l3	A	G	8: 109,646,497		probably benign	Het
Ppm1d	A	T	11: 85,345,715	E440V	probably damaging	Het
Ripor2	A	T	13: 24,731,589	E1047D	probably damaging	Het
Rwdd2b	G	A	16: 87,437,448	A18V	probably benign	Het
Serpina5	G	T	12: 104,102,125	K148N	probably damaging	Het
Setx	A	G	2: 29,146,964	K1154E	probably benign	Het
Skap1	T	A	11: 96,708,556		probably null	Het
Spcs2	T	C	7: 99,849,034	K81R	probably damaging	Het
Stt3b	T	A	9: 115,250,907	M646L	possibly damaging	Het
Suco	T	C	1: 161,818,626	T1169A	probably benign	Het
Susd1	A	T	4: 59,427,985	Y66*	probably null	Het
Trim58	G	A	11: 58,651,350	G379S	probably damaging	Het
Vmn2r50	T	A	7: 10,053,075	Q35L	probably benign	Het
Zfp418	T	C	7: 7,174,691		probably benign	Het
Zfp57	G	A	17: 37,010,027	V258I	probably benign	Het

Other mutations in Trim34a

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00503:Trim34a	APN	7	104261331	missense	probably damaging	1.00
IGL00826:Trim34a	APN	7	104260933	splice site	probably null
IGL01526:Trim34a	APN	7	104260499	missense	probably damaging	1.00
IGL01859:Trim34a	APN	7	104260942	missense	probably damaging	0.96
IGL02052:Trim34a	APN	7	104247831	missense	probably benign	0.33
IGL02192:Trim34a	APN	7	104247732	start codon destroyed	probably null	1.00
IGL02358:Trim34a	APN	7	104261234	nonsense	probably null
IGL03326:Trim34a	APN	7	104261380	missense	probably benign	0.03
IGL03366:Trim34a	APN	7	104260933	splice site	probably null
Gold_belt	UTSW	7	104261064	nonsense	probably null
PIT4472001:Trim34a	UTSW	7	104247948	missense	probably damaging	1.00
PIT4791001:Trim34a	UTSW	7	104260484	missense	probably benign	0.15
R0115:Trim34a	UTSW	7	104247902	missense	probably damaging	1.00
R0848:Trim34a	UTSW	7	104261124	missense	probably benign
R1016:Trim34a	UTSW	7	104247960	missense	probably benign	0.10
R1477:Trim34a	UTSW	7	104248080	missense	possibly damaging	0.81
R1622:Trim34a	UTSW	7	104261338	splice site	probably null
R2287:Trim34a	UTSW	7	104261055	missense	probably damaging	1.00
R3685:Trim34a	UTSW	7	104260126	splice site	probably null
R4166:Trim34a	UTSW	7	104261016	missense	probably benign	0.02
R4967:Trim34a	UTSW	7	104261064	nonsense	probably null
R4979:Trim34a	UTSW	7	104247862	missense	probably benign	0.00
R5194:Trim34a	UTSW	7	104260993	missense	possibly damaging	0.70
R5443:Trim34a	UTSW	7	104260213	missense	possibly damaging	0.80
R5631:Trim34a	UTSW	7	104248739	missense	probably damaging	1.00
R5902:Trim34a	UTSW	7	104261121	nonsense	probably null
R6147:Trim34a	UTSW	7	104261191	missense	probably damaging	0.99
R6644:Trim34a	UTSW	7	104261037	missense	probably damaging	1.00
R7971:Trim34a	UTSW	7	104247818	missense	probably damaging	0.98
R8060:Trim34a	UTSW	7	104260976	missense	probably damaging	1.00
R8278:Trim34a	UTSW	7	104249416	missense	probably damaging	0.99
R8356:Trim34a	UTSW	7	104260971	missense	probably damaging	0.99
R9275:Trim34a	UTSW	7	104260994	missense	probably damaging	0.96
R9563:Trim34a	UTSW	7	104261121	nonsense	probably null
X0023:Trim34a	UTSW	7	104259415	missense	probably benign	0.43

Posted On

2015-04-16