Incidental Mutation 'IGL02352:Gm17727'
ID289512
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm17727
Ensembl Gene ENSMUSG00000090738
Gene Namepredicted gene, 17727
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.066) question?
Stock #IGL02352
Quality Score
Status
Chromosome9
Chromosomal Location35776524-35778109 bp(-) (GRCm38)
Type of Mutationstart codon destroyed
DNA Base Change (assembly) A to T at 35777884 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Lysine at position 1 (M1K)
Ref Sequence ENSEMBL: ENSMUSP00000129553 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171898] [ENSMUST00000184431]
Predicted Effect probably null
Transcript: ENSMUST00000171898
AA Change: M1K

PolyPhen 2 Score 0.041 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000129553
Gene: ENSMUSG00000090738
AA Change: M1K

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000184431
SMART Domains Protein: ENSMUSP00000139380
Gene: ENSMUSG00000098847

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
low complexity region 32 43 N/A INTRINSIC
low complexity region 64 81 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930447C04Rik A C 12: 72,895,055 probably null Het
Abca5 T A 11: 110,275,330 N1540I probably benign Het
Adamtsl5 T A 10: 80,343,728 probably null Het
Aldh2 T C 5: 121,575,897 E128G probably null Het
Anln A G 9: 22,368,412 V494A probably benign Het
Ano3 A T 2: 110,884,943 L50* probably null Het
Atp13a3 A G 16: 30,351,084 I392T probably damaging Het
C1qtnf5 A G 9: 44,108,334 E85G possibly damaging Het
Cacna1s A T 1: 136,093,252 probably benign Het
Ccdc150 G A 1: 54,272,521 R222H probably benign Het
Cdk5rap3 A T 11: 96,916,177 I9N probably damaging Het
Cmip A T 8: 117,411,255 probably benign Het
Cyp21a1 A G 17: 34,804,222 Y60H probably damaging Het
Cyp2d11 A G 15: 82,393,920 W10R possibly damaging Het
Dock10 A G 1: 80,505,661 Y2076H probably damaging Het
Egflam T C 15: 7,234,225 N748S probably benign Het
Fam227b A G 2: 126,146,254 probably benign Het
Fancd2 T A 6: 113,563,112 I654N probably damaging Het
Gm17018 G T 19: 45,577,054 A156S probably benign Het
Hpf1 A G 8: 60,896,802 I155V probably benign Het
Hrh1 C A 6: 114,480,443 N228K probably benign Het
Igkv3-2 T C 6: 70,698,490 L8P probably damaging Het
Iqgap3 T C 3: 88,101,960 F734L probably benign Het
Kif5a T C 10: 127,243,501 Y276C probably damaging Het
Lax1 A T 1: 133,680,470 S178T possibly damaging Het
March6 C T 15: 31,509,759 C28Y probably damaging Het
Mylk3 T C 8: 85,355,302 T356A probably benign Het
Obscn T C 11: 59,001,027 E6893G probably benign Het
Olfr166 T C 16: 19,487,177 L113P probably damaging Het
Pgap2 G T 7: 102,236,139 V71F probably damaging Het
Prob1 T G 18: 35,652,840 E787A possibly damaging Het
Psmd2 C A 16: 20,656,941 D430E probably benign Het
Reln C A 5: 22,039,565 G805V possibly damaging Het
Serpinb9e A T 13: 33,257,820 probably benign Het
Sgsm2 G T 11: 74,892,074 probably benign Het
Slc38a9 A G 13: 112,690,186 I153V probably benign Het
Slco1b2 T A 6: 141,685,525 D628E probably damaging Het
Sult2a5 T C 7: 13,628,802 S145P probably benign Het
Sv2b T C 7: 75,136,449 T408A probably benign Het
Usp24 T C 4: 106,403,925 C1626R probably damaging Het
Wdr43 C T 17: 71,632,048 T217M possibly damaging Het
Wdr95 G A 5: 149,580,619 V155M probably damaging Het
Wsb1 G A 11: 79,251,012 L60F probably damaging Het
Wwp2 C T 8: 107,540,646 R297* probably null Het
Xkr6 T C 14: 63,819,707 Y356H unknown Het
Other mutations in Gm17727
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01285:Gm17727 APN 9 35776748 missense possibly damaging 0.73
IGL02044:Gm17727 APN 9 35776663 missense probably benign 0.19
IGL02359:Gm17727 APN 9 35777884 start codon destroyed probably null 0.04
R0827:Gm17727 UTSW 9 35777851 missense probably damaging 0.97
R1382:Gm17727 UTSW 9 35778094 start gained probably benign
R1591:Gm17727 UTSW 9 35776656 missense probably damaging 0.99
R1794:Gm17727 UTSW 9 35777122 missense probably benign 0.01
R5419:Gm17727 UTSW 9 35778111 unclassified probably null
R6110:Gm17727 UTSW 9 35777146 missense possibly damaging 0.90
R6379:Gm17727 UTSW 9 35778085 start gained probably benign
R6614:Gm17727 UTSW 9 35777125 missense probably damaging 0.99
R7698:Gm17727 UTSW 9 35777176 missense probably benign 0.27
R7833:Gm17727 UTSW 9 35777110 missense probably damaging 1.00
R7916:Gm17727 UTSW 9 35777110 missense probably damaging 1.00
Posted On2015-04-16