Incidental Mutation 'IGL02355:Scnn1b'
ID |
289645 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Scnn1b
|
Ensembl Gene |
ENSMUSG00000030873 |
Gene Name |
sodium channel, nonvoltage-gated 1 beta |
Synonyms |
ENaC beta |
Accession Numbers |
|
Essential gene? |
Essential
(E-score: 1.000)
|
Stock # |
IGL02355
|
Quality Score |
|
Status
|
|
Chromosome |
7 |
Chromosomal Location |
121464261-121517737 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to A
at 121516770 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Arginine to Histidine
at position 503
(R503H)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000033161
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000033161]
[ENSMUST00000205438]
[ENSMUST00000205520]
|
AlphaFold |
Q9WU38 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000033161
AA Change: R503H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000033161 Gene: ENSMUSG00000030873 AA Change: R503H
Domain | Start | End | E-Value | Type |
Pfam:ASC
|
29 |
541 |
2.4e-93 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000205438
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000205520
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the beta subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), and Liddle syndrome. [provided by RefSeq, Apr 2009] PHENOTYPE: Homozygous mutation of this gene results in death shortly after birth, decreased serum sodium levels but higher urine sodium levels and increased serum potassium and chloride levels but lower potassium urine levels. Another homozygous mutation exhibits no abnormal phenotype. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 42 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adam3 |
C |
A |
8: 25,187,207 (GRCm39) |
C428F |
probably damaging |
Het |
Alas1 |
T |
C |
9: 106,113,838 (GRCm39) |
Y469C |
probably damaging |
Het |
Asxl1 |
C |
T |
2: 153,243,706 (GRCm39) |
L1419F |
probably benign |
Het |
Bcan |
C |
T |
3: 87,901,449 (GRCm39) |
D418N |
possibly damaging |
Het |
Cdc42bpg |
A |
G |
19: 6,360,839 (GRCm39) |
D199G |
possibly damaging |
Het |
Chst15 |
T |
C |
7: 131,868,401 (GRCm39) |
N340D |
probably benign |
Het |
Col12a1 |
T |
G |
9: 79,537,993 (GRCm39) |
|
probably benign |
Het |
Cyp2c67 |
T |
A |
19: 39,631,849 (GRCm39) |
H116L |
probably benign |
Het |
Cyp2c67 |
G |
A |
19: 39,605,826 (GRCm39) |
R357* |
probably null |
Het |
Ears2 |
T |
C |
7: 121,643,773 (GRCm39) |
D395G |
probably benign |
Het |
Fam227a |
A |
T |
15: 79,528,139 (GRCm39) |
|
probably benign |
Het |
Fap |
A |
G |
2: 62,403,842 (GRCm39) |
V11A |
probably benign |
Het |
Ganc |
A |
G |
2: 120,264,238 (GRCm39) |
D397G |
probably damaging |
Het |
Gjb6 |
C |
A |
14: 57,361,752 (GRCm39) |
G170C |
possibly damaging |
Het |
Gria2 |
A |
T |
3: 80,614,244 (GRCm39) |
W599R |
probably damaging |
Het |
Gvin-ps5 |
T |
C |
7: 105,929,480 (GRCm39) |
|
noncoding transcript |
Het |
Ighv1-64 |
A |
G |
12: 115,471,236 (GRCm39) |
S94P |
probably benign |
Het |
Kifc3 |
C |
T |
8: 95,836,507 (GRCm39) |
A85T |
probably damaging |
Het |
Lifr |
G |
A |
15: 7,194,174 (GRCm39) |
|
probably null |
Het |
Lonp2 |
T |
G |
8: 87,350,874 (GRCm39) |
S21R |
probably benign |
Het |
Nxpe3 |
A |
G |
16: 55,710,949 (GRCm39) |
V30A |
probably benign |
Het |
Olfml1 |
T |
C |
7: 107,167,010 (GRCm39) |
V13A |
probably benign |
Het |
Or10w1 |
T |
C |
19: 13,632,597 (GRCm39) |
V268A |
probably benign |
Het |
Or1af1 |
A |
G |
2: 37,109,681 (GRCm39) |
Y60C |
probably damaging |
Het |
Pcnt |
G |
A |
10: 76,210,996 (GRCm39) |
Q2376* |
probably null |
Het |
Pglyrp2 |
A |
G |
17: 32,635,996 (GRCm39) |
L380P |
probably damaging |
Het |
Plin3 |
A |
G |
17: 56,593,636 (GRCm39) |
V26A |
probably benign |
Het |
Potefam1 |
T |
C |
2: 111,041,996 (GRCm39) |
|
probably benign |
Het |
Pramel25 |
A |
G |
4: 143,519,580 (GRCm39) |
S114G |
probably damaging |
Het |
Rims1 |
A |
G |
1: 22,522,288 (GRCm39) |
I470T |
probably damaging |
Het |
Rora |
T |
C |
9: 69,281,374 (GRCm39) |
Y329H |
probably damaging |
Het |
Sec14l1 |
A |
G |
11: 117,035,675 (GRCm39) |
D237G |
possibly damaging |
Het |
Selplg |
A |
G |
5: 113,957,467 (GRCm39) |
S280P |
probably benign |
Het |
Serpina12 |
A |
G |
12: 104,004,140 (GRCm39) |
L164P |
probably benign |
Het |
Sik2 |
C |
T |
9: 50,828,903 (GRCm39) |
W176* |
probably null |
Het |
Slc2a1 |
T |
C |
4: 118,993,612 (GRCm39) |
F483S |
possibly damaging |
Het |
Speg |
A |
G |
1: 75,400,559 (GRCm39) |
D2573G |
possibly damaging |
Het |
Stil |
C |
T |
4: 114,867,308 (GRCm39) |
S239L |
probably damaging |
Het |
Tmem94 |
C |
A |
11: 115,685,571 (GRCm39) |
S941R |
probably damaging |
Het |
Tnfrsf11b |
T |
A |
15: 54,115,778 (GRCm39) |
D273V |
probably damaging |
Het |
Tns2 |
A |
G |
15: 102,020,725 (GRCm39) |
T864A |
probably benign |
Het |
Zfpm2 |
A |
G |
15: 40,962,890 (GRCm39) |
H184R |
probably damaging |
Het |
|
Other mutations in Scnn1b |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01021:Scnn1b
|
APN |
7 |
121,517,259 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01108:Scnn1b
|
APN |
7 |
121,513,555 (GRCm39) |
splice site |
probably null |
|
IGL02191:Scnn1b
|
APN |
7 |
121,516,736 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02197:Scnn1b
|
APN |
7 |
121,502,113 (GRCm39) |
missense |
probably null |
0.89 |
IGL02362:Scnn1b
|
APN |
7 |
121,516,770 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02554:Scnn1b
|
APN |
7 |
121,516,746 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02834:Scnn1b
|
APN |
7 |
121,511,285 (GRCm39) |
missense |
probably damaging |
1.00 |
R0266:Scnn1b
|
UTSW |
7 |
121,511,698 (GRCm39) |
missense |
probably damaging |
1.00 |
R0494:Scnn1b
|
UTSW |
7 |
121,498,681 (GRCm39) |
missense |
probably damaging |
1.00 |
R0849:Scnn1b
|
UTSW |
7 |
121,511,698 (GRCm39) |
missense |
probably damaging |
1.00 |
R0872:Scnn1b
|
UTSW |
7 |
121,513,553 (GRCm39) |
critical splice donor site |
probably null |
|
R0899:Scnn1b
|
UTSW |
7 |
121,516,938 (GRCm39) |
missense |
probably damaging |
1.00 |
R1386:Scnn1b
|
UTSW |
7 |
121,501,711 (GRCm39) |
missense |
possibly damaging |
0.60 |
R1406:Scnn1b
|
UTSW |
7 |
121,501,767 (GRCm39) |
critical splice donor site |
probably null |
|
R1406:Scnn1b
|
UTSW |
7 |
121,501,767 (GRCm39) |
critical splice donor site |
probably null |
|
R1662:Scnn1b
|
UTSW |
7 |
121,501,551 (GRCm39) |
missense |
probably benign |
0.00 |
R1782:Scnn1b
|
UTSW |
7 |
121,517,184 (GRCm39) |
missense |
probably benign |
|
R1829:Scnn1b
|
UTSW |
7 |
121,502,068 (GRCm39) |
missense |
probably benign |
0.00 |
R1861:Scnn1b
|
UTSW |
7 |
121,513,484 (GRCm39) |
missense |
probably damaging |
1.00 |
R1928:Scnn1b
|
UTSW |
7 |
121,509,670 (GRCm39) |
missense |
probably damaging |
1.00 |
R4016:Scnn1b
|
UTSW |
7 |
121,513,555 (GRCm39) |
splice site |
probably null |
|
R4192:Scnn1b
|
UTSW |
7 |
121,501,962 (GRCm39) |
missense |
possibly damaging |
0.63 |
R4504:Scnn1b
|
UTSW |
7 |
121,511,698 (GRCm39) |
missense |
probably damaging |
1.00 |
R4745:Scnn1b
|
UTSW |
7 |
121,501,509 (GRCm39) |
missense |
probably benign |
0.03 |
R4888:Scnn1b
|
UTSW |
7 |
121,502,110 (GRCm39) |
missense |
probably benign |
0.06 |
R4941:Scnn1b
|
UTSW |
7 |
121,511,231 (GRCm39) |
missense |
probably damaging |
1.00 |
R5121:Scnn1b
|
UTSW |
7 |
121,502,110 (GRCm39) |
missense |
probably benign |
0.06 |
R6379:Scnn1b
|
UTSW |
7 |
121,514,551 (GRCm39) |
missense |
probably benign |
0.10 |
R6516:Scnn1b
|
UTSW |
7 |
121,511,335 (GRCm39) |
missense |
probably damaging |
1.00 |
R6650:Scnn1b
|
UTSW |
7 |
121,502,043 (GRCm39) |
missense |
probably damaging |
0.97 |
R6730:Scnn1b
|
UTSW |
7 |
121,502,100 (GRCm39) |
missense |
probably damaging |
1.00 |
R7151:Scnn1b
|
UTSW |
7 |
121,517,109 (GRCm39) |
missense |
probably damaging |
1.00 |
R8670:Scnn1b
|
UTSW |
7 |
121,498,472 (GRCm39) |
missense |
probably benign |
0.06 |
R8675:Scnn1b
|
UTSW |
7 |
121,498,474 (GRCm39) |
missense |
probably damaging |
1.00 |
R8930:Scnn1b
|
UTSW |
7 |
121,502,067 (GRCm39) |
missense |
probably damaging |
0.99 |
R8932:Scnn1b
|
UTSW |
7 |
121,502,067 (GRCm39) |
missense |
probably damaging |
0.99 |
R9170:Scnn1b
|
UTSW |
7 |
121,511,326 (GRCm39) |
missense |
probably benign |
0.32 |
R9204:Scnn1b
|
UTSW |
7 |
121,498,522 (GRCm39) |
missense |
probably benign |
0.20 |
R9339:Scnn1b
|
UTSW |
7 |
121,511,254 (GRCm39) |
missense |
probably damaging |
0.98 |
R9466:Scnn1b
|
UTSW |
7 |
121,502,013 (GRCm39) |
missense |
probably damaging |
1.00 |
R9696:Scnn1b
|
UTSW |
7 |
121,498,462 (GRCm39) |
start codon destroyed |
probably damaging |
0.99 |
R9709:Scnn1b
|
UTSW |
7 |
121,509,693 (GRCm39) |
missense |
probably benign |
|
|
Posted On |
2015-04-16 |