Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02355:Olfml1'

289646

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfml1

Ensembl Gene

ENSMUSG00000051041

Gene Name

olfactomedin-like 1

Synonyms

mONT2, ONT2, MVAL564

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.081) question?

Stock #

IGL02355

Quality Score

Status

Chromosome

Chromosomal Location

107166653-107190301 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 107167010 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 13 (V13A)

Ref Sequence

ENSEMBL: ENSMUSP00000114029 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000120990]

AlphaFold

Q8BSH2

Predicted Effect

probably benign
Transcript: ENSMUST00000120990
AA Change: V13A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000114029
Gene: ENSMUSG00000051041
AA Change: V13A

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
coiled coil region	78	105	N/A	INTRINSIC
low complexity region	115	132	N/A	INTRINSIC
Pfam:OLF	145	233	5.5e-19	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam3	C	A	8: 25,187,207 (GRCm39)	C428F	probably damaging	Het
Alas1	T	C	9: 106,113,838 (GRCm39)	Y469C	probably damaging	Het
Asxl1	C	T	2: 153,243,706 (GRCm39)	L1419F	probably benign	Het
Bcan	C	T	3: 87,901,449 (GRCm39)	D418N	possibly damaging	Het
Cdc42bpg	A	G	19: 6,360,839 (GRCm39)	D199G	possibly damaging	Het
Chst15	T	C	7: 131,868,401 (GRCm39)	N340D	probably benign	Het
Col12a1	T	G	9: 79,537,993 (GRCm39)		probably benign	Het
Cyp2c67	T	A	19: 39,631,849 (GRCm39)	H116L	probably benign	Het
Cyp2c67	G	A	19: 39,605,826 (GRCm39)	R357*	probably null	Het
Ears2	T	C	7: 121,643,773 (GRCm39)	D395G	probably benign	Het
Fam227a	A	T	15: 79,528,139 (GRCm39)		probably benign	Het
Fap	A	G	2: 62,403,842 (GRCm39)	V11A	probably benign	Het
Ganc	A	G	2: 120,264,238 (GRCm39)	D397G	probably damaging	Het
Gjb6	C	A	14: 57,361,752 (GRCm39)	G170C	possibly damaging	Het
Gria2	A	T	3: 80,614,244 (GRCm39)	W599R	probably damaging	Het
Gvin-ps5	T	C	7: 105,929,480 (GRCm39)		noncoding transcript	Het
Ighv1-64	A	G	12: 115,471,236 (GRCm39)	S94P	probably benign	Het
Kifc3	C	T	8: 95,836,507 (GRCm39)	A85T	probably damaging	Het
Lifr	G	A	15: 7,194,174 (GRCm39)		probably null	Het
Lonp2	T	G	8: 87,350,874 (GRCm39)	S21R	probably benign	Het
Nxpe3	A	G	16: 55,710,949 (GRCm39)	V30A	probably benign	Het
Or10w1	T	C	19: 13,632,597 (GRCm39)	V268A	probably benign	Het
Or1af1	A	G	2: 37,109,681 (GRCm39)	Y60C	probably damaging	Het
Pcnt	G	A	10: 76,210,996 (GRCm39)	Q2376*	probably null	Het
Pglyrp2	A	G	17: 32,635,996 (GRCm39)	L380P	probably damaging	Het
Plin3	A	G	17: 56,593,636 (GRCm39)	V26A	probably benign	Het
Potefam1	T	C	2: 111,041,996 (GRCm39)		probably benign	Het
Pramel25	A	G	4: 143,519,580 (GRCm39)	S114G	probably damaging	Het
Rims1	A	G	1: 22,522,288 (GRCm39)	I470T	probably damaging	Het
Rora	T	C	9: 69,281,374 (GRCm39)	Y329H	probably damaging	Het
Scnn1b	G	A	7: 121,516,770 (GRCm39)	R503H	probably damaging	Het
Sec14l1	A	G	11: 117,035,675 (GRCm39)	D237G	possibly damaging	Het
Selplg	A	G	5: 113,957,467 (GRCm39)	S280P	probably benign	Het
Serpina12	A	G	12: 104,004,140 (GRCm39)	L164P	probably benign	Het
Sik2	C	T	9: 50,828,903 (GRCm39)	W176*	probably null	Het
Slc2a1	T	C	4: 118,993,612 (GRCm39)	F483S	possibly damaging	Het
Speg	A	G	1: 75,400,559 (GRCm39)	D2573G	possibly damaging	Het
Stil	C	T	4: 114,867,308 (GRCm39)	S239L	probably damaging	Het
Tmem94	C	A	11: 115,685,571 (GRCm39)	S941R	probably damaging	Het
Tnfrsf11b	T	A	15: 54,115,778 (GRCm39)	D273V	probably damaging	Het
Tns2	A	G	15: 102,020,725 (GRCm39)	T864A	probably benign	Het
Zfpm2	A	G	15: 40,962,890 (GRCm39)	H184R	probably damaging	Het

Other mutations in Olfml1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01285:Olfml1	APN	7	107,189,364 (GRCm39)	missense	possibly damaging	0.80
IGL02362:Olfml1	APN	7	107,167,010 (GRCm39)	missense	probably benign	0.00
IGL03218:Olfml1	APN	7	107,170,476 (GRCm39)	missense	possibly damaging	0.87
IGL03291:Olfml1	APN	7	107,189,436 (GRCm39)	missense	probably damaging	1.00
R0041:Olfml1	UTSW	7	107,189,393 (GRCm39)	missense	possibly damaging	0.81
R0041:Olfml1	UTSW	7	107,189,393 (GRCm39)	missense	possibly damaging	0.81
R0081:Olfml1	UTSW	7	107,170,506 (GRCm39)	missense	probably benign	0.08
R0524:Olfml1	UTSW	7	107,189,384 (GRCm39)	missense	probably damaging	1.00
R1311:Olfml1	UTSW	7	107,167,103 (GRCm39)	critical splice donor site	probably null
R1548:Olfml1	UTSW	7	107,189,582 (GRCm39)	missense	possibly damaging	0.88
R1564:Olfml1	UTSW	7	107,170,346 (GRCm39)	missense	possibly damaging	0.89
R4347:Olfml1	UTSW	7	107,167,040 (GRCm39)	missense	probably benign	0.00
R4997:Olfml1	UTSW	7	107,170,413 (GRCm39)	missense	probably damaging	1.00
R6788:Olfml1	UTSW	7	107,167,075 (GRCm39)	missense	probably damaging	1.00
R7282:Olfml1	UTSW	7	107,189,530 (GRCm39)	missense	possibly damaging	0.85
R7703:Olfml1	UTSW	7	107,170,392 (GRCm39)	missense	probably damaging	1.00
R7922:Olfml1	UTSW	7	107,170,356 (GRCm39)	missense	probably damaging	1.00
R8324:Olfml1	UTSW	7	107,189,570 (GRCm39)	missense	probably benign	0.04
R8441:Olfml1	UTSW	7	107,166,977 (GRCm39)	missense	probably benign	0.00
R9002:Olfml1	UTSW	7	107,189,423 (GRCm39)	missense	probably damaging	1.00
R9261:Olfml1	UTSW	7	107,167,007 (GRCm39)	missense	possibly damaging	0.88
R9797:Olfml1	UTSW	7	107,167,069 (GRCm39)	missense	probably benign	0.25

Posted On

2015-04-16