Incidental Mutation 'IGL02355:Pglyrp2'
ID 289662
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pglyrp2
Ensembl Gene ENSMUSG00000079563
Gene Name peptidoglycan recognition protein 2
Synonyms tagL-alpha, C730002N09Rik, Pglyrpl, tagl-beta, tagL, PGRP-L
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02355
Quality Score
Status
Chromosome 17
Chromosomal Location 32631433-32643141 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 32635996 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 380 (L380P)
Ref Sequence ENSEMBL: ENSMUSP00000129964 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000114455] [ENSMUST00000170392]
AlphaFold Q8VCS0
Predicted Effect probably damaging
Transcript: ENSMUST00000114455
AA Change: L380P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000110099
Gene: ENSMUSG00000079563
AA Change: L380P

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
low complexity region 251 266 N/A INTRINSIC
low complexity region 270 281 N/A INTRINSIC
PGRP 360 506 6.61e-78 SMART
Ami_2 373 512 6.28e-10 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000170392
AA Change: L380P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000129964
Gene: ENSMUSG00000079563
AA Change: L380P

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
low complexity region 251 266 N/A INTRINSIC
low complexity region 270 281 N/A INTRINSIC
PGRP 360 506 6.61e-78 SMART
Ami_2 373 512 6.28e-10 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. This protein hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in bacterial cell wall glycopeptides, and thus may play a scavenger role by digesting biologically active peptidoglycan into biologically inactive fragments. [provided by RefSeq, Sep 2011]
PHENOTYPE: Mice homozygous for disruption of this gene are viable and fertile with no gross developmental defects. Mice homozygous for a different knock-out allele are resistant to peptidoglycan- or muramyl dipeptide-induced arthritis and increased susceptibility to DSS-induced colitis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam3 C A 8: 25,187,207 (GRCm39) C428F probably damaging Het
Alas1 T C 9: 106,113,838 (GRCm39) Y469C probably damaging Het
Asxl1 C T 2: 153,243,706 (GRCm39) L1419F probably benign Het
Bcan C T 3: 87,901,449 (GRCm39) D418N possibly damaging Het
Cdc42bpg A G 19: 6,360,839 (GRCm39) D199G possibly damaging Het
Chst15 T C 7: 131,868,401 (GRCm39) N340D probably benign Het
Col12a1 T G 9: 79,537,993 (GRCm39) probably benign Het
Cyp2c67 T A 19: 39,631,849 (GRCm39) H116L probably benign Het
Cyp2c67 G A 19: 39,605,826 (GRCm39) R357* probably null Het
Ears2 T C 7: 121,643,773 (GRCm39) D395G probably benign Het
Fam227a A T 15: 79,528,139 (GRCm39) probably benign Het
Fap A G 2: 62,403,842 (GRCm39) V11A probably benign Het
Ganc A G 2: 120,264,238 (GRCm39) D397G probably damaging Het
Gjb6 C A 14: 57,361,752 (GRCm39) G170C possibly damaging Het
Gria2 A T 3: 80,614,244 (GRCm39) W599R probably damaging Het
Gvin-ps5 T C 7: 105,929,480 (GRCm39) noncoding transcript Het
Ighv1-64 A G 12: 115,471,236 (GRCm39) S94P probably benign Het
Kifc3 C T 8: 95,836,507 (GRCm39) A85T probably damaging Het
Lifr G A 15: 7,194,174 (GRCm39) probably null Het
Lonp2 T G 8: 87,350,874 (GRCm39) S21R probably benign Het
Nxpe3 A G 16: 55,710,949 (GRCm39) V30A probably benign Het
Olfml1 T C 7: 107,167,010 (GRCm39) V13A probably benign Het
Or10w1 T C 19: 13,632,597 (GRCm39) V268A probably benign Het
Or1af1 A G 2: 37,109,681 (GRCm39) Y60C probably damaging Het
Pcnt G A 10: 76,210,996 (GRCm39) Q2376* probably null Het
Plin3 A G 17: 56,593,636 (GRCm39) V26A probably benign Het
Potefam1 T C 2: 111,041,996 (GRCm39) probably benign Het
Pramel25 A G 4: 143,519,580 (GRCm39) S114G probably damaging Het
Rims1 A G 1: 22,522,288 (GRCm39) I470T probably damaging Het
Rora T C 9: 69,281,374 (GRCm39) Y329H probably damaging Het
Scnn1b G A 7: 121,516,770 (GRCm39) R503H probably damaging Het
Sec14l1 A G 11: 117,035,675 (GRCm39) D237G possibly damaging Het
Selplg A G 5: 113,957,467 (GRCm39) S280P probably benign Het
Serpina12 A G 12: 104,004,140 (GRCm39) L164P probably benign Het
Sik2 C T 9: 50,828,903 (GRCm39) W176* probably null Het
Slc2a1 T C 4: 118,993,612 (GRCm39) F483S possibly damaging Het
Speg A G 1: 75,400,559 (GRCm39) D2573G possibly damaging Het
Stil C T 4: 114,867,308 (GRCm39) S239L probably damaging Het
Tmem94 C A 11: 115,685,571 (GRCm39) S941R probably damaging Het
Tnfrsf11b T A 15: 54,115,778 (GRCm39) D273V probably damaging Het
Tns2 A G 15: 102,020,725 (GRCm39) T864A probably benign Het
Zfpm2 A G 15: 40,962,890 (GRCm39) H184R probably damaging Het
Other mutations in Pglyrp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01935:Pglyrp2 APN 17 32,637,551 (GRCm39) missense probably benign 0.14
IGL01949:Pglyrp2 APN 17 32,635,080 (GRCm39) splice site probably null
IGL02362:Pglyrp2 APN 17 32,635,996 (GRCm39) missense probably damaging 1.00
IGL02601:Pglyrp2 APN 17 32,634,835 (GRCm39) missense probably benign 0.04
IGL02965:Pglyrp2 APN 17 32,637,560 (GRCm39) missense probably benign 0.00
R0324:Pglyrp2 UTSW 17 32,637,302 (GRCm39) missense probably benign 0.00
R0386:Pglyrp2 UTSW 17 32,639,836 (GRCm39) start codon destroyed probably null 0.93
R2158:Pglyrp2 UTSW 17 32,637,222 (GRCm39) missense probably benign 0.12
R2181:Pglyrp2 UTSW 17 32,637,936 (GRCm39) missense probably damaging 1.00
R2191:Pglyrp2 UTSW 17 32,634,931 (GRCm39) missense probably benign 0.04
R2313:Pglyrp2 UTSW 17 32,637,673 (GRCm39) missense probably damaging 1.00
R4825:Pglyrp2 UTSW 17 32,637,235 (GRCm39) missense probably benign 0.00
R4852:Pglyrp2 UTSW 17 32,634,823 (GRCm39) missense probably benign 0.09
R4888:Pglyrp2 UTSW 17 32,637,771 (GRCm39) missense probably benign 0.26
R6941:Pglyrp2 UTSW 17 32,635,048 (GRCm39) missense probably damaging 1.00
R7014:Pglyrp2 UTSW 17 32,634,904 (GRCm39) missense probably damaging 0.98
R7327:Pglyrp2 UTSW 17 32,634,893 (GRCm39) missense probably benign 0.16
R7886:Pglyrp2 UTSW 17 32,637,735 (GRCm39) missense possibly damaging 0.53
R8179:Pglyrp2 UTSW 17 32,635,003 (GRCm39) missense possibly damaging 0.51
R8734:Pglyrp2 UTSW 17 32,634,976 (GRCm39) missense probably damaging 0.99
Posted On 2015-04-16