Incidental Mutation 'IGL02335:Vmn2r22'
ID 289672
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r22
Ensembl Gene ENSMUSG00000095486
Gene Name vomeronasal 2, receptor 22
Synonyms EG546913
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # IGL02335
Quality Score
Status
Chromosome 6
Chromosomal Location 123586717-123627594 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 123615051 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Arginine at position 180 (S180R)
Ref Sequence ENSEMBL: ENSMUSP00000132043 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170808]
AlphaFold E9Q7S8
Predicted Effect probably damaging
Transcript: ENSMUST00000170808
AA Change: S180R

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000132043
Gene: ENSMUSG00000095486
AA Change: S180R

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:ANF_receptor 81 473 1.4e-32 PFAM
Pfam:NCD3G 517 570 2.2e-23 PFAM
Pfam:7tm_3 601 838 1.2e-54 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A4gnt C T 9: 99,502,266 (GRCm39) T142I probably benign Het
Aadacl2fm2 G A 3: 59,651,026 (GRCm39) M49I probably benign Het
Acaca A G 11: 84,105,084 (GRCm39) T147A possibly damaging Het
Agbl3 A G 6: 34,776,685 (GRCm39) D397G probably damaging Het
Ank1 C T 8: 23,625,654 (GRCm39) T1597M possibly damaging Het
Arl4d A G 11: 101,557,755 (GRCm39) T94A possibly damaging Het
Cd22 A G 7: 30,575,559 (GRCm39) I161T probably damaging Het
Clcn7 C T 17: 25,365,821 (GRCm39) L166F probably benign Het
Cnbd1 G T 4: 19,055,095 (GRCm39) N110K possibly damaging Het
Col14a1 A T 15: 55,327,165 (GRCm39) probably benign Het
Col6a6 C T 9: 105,661,300 (GRCm39) V270M probably damaging Het
Cox8b C A 7: 140,478,990 (GRCm39) G42W probably damaging Het
Csn1s1 A T 5: 87,828,704 (GRCm39) D275V probably benign Het
Cubn T A 2: 13,432,645 (GRCm39) probably null Het
Dctn2 T C 10: 127,111,690 (GRCm39) probably benign Het
Dnm1l A G 16: 16,160,604 (GRCm39) probably benign Het
Dpp4 T C 2: 62,164,988 (GRCm39) E687G probably benign Het
Fbxw20 T C 9: 109,052,377 (GRCm39) K249E possibly damaging Het
Fhl2 C T 1: 43,167,550 (GRCm39) W181* probably null Het
G2e3 T A 12: 51,415,941 (GRCm39) M559K probably benign Het
Gdap1l1 A T 2: 163,289,515 (GRCm39) Y160F possibly damaging Het
Gm1110 T C 9: 26,793,059 (GRCm39) I572M probably benign Het
Gpatch2l T A 12: 86,303,711 (GRCm39) probably benign Het
Kcnq4 A G 4: 120,573,051 (GRCm39) L250P probably damaging Het
Lamc2 A T 1: 153,041,962 (GRCm39) N57K probably benign Het
Lingo1 A G 9: 56,527,365 (GRCm39) L408P probably damaging Het
Mmrn1 A T 6: 60,954,131 (GRCm39) N804I possibly damaging Het
Mroh7 A G 4: 106,564,979 (GRCm39) L545S probably damaging Het
Nup188 T A 2: 30,213,648 (GRCm39) probably null Het
Or10q1 A G 19: 13,727,298 (GRCm39) D276G probably benign Het
Or11a4 A G 17: 37,536,217 (GRCm39) N67S probably damaging Het
Or5b94 T C 19: 12,651,602 (GRCm39) I11T probably damaging Het
Pls1 A T 9: 95,666,236 (GRCm39) N138K probably benign Het
Prkch C A 12: 73,749,286 (GRCm39) N345K probably benign Het
Reps1 T C 10: 17,931,865 (GRCm39) probably null Het
Rrp7a T C 15: 83,006,892 (GRCm39) E15G probably benign Het
Scart2 A T 7: 139,876,453 (GRCm39) N526Y probably damaging Het
Scn1a T A 2: 66,108,005 (GRCm39) T1557S possibly damaging Het
Smtn T C 11: 3,476,215 (GRCm39) E602G probably damaging Het
Syvn1 T C 19: 6,100,123 (GRCm39) probably null Het
Tbxas1 A G 6: 39,000,014 (GRCm39) D267G probably damaging Het
Topbp1 A G 9: 103,205,722 (GRCm39) N787D probably damaging Het
Zfp345 T A 2: 150,316,463 (GRCm39) E48D possibly damaging Het
Zfp608 G A 18: 55,030,509 (GRCm39) Q1144* probably null Het
Zfp936 T A 7: 42,836,691 (GRCm39) L34Q probably damaging Het
Other mutations in Vmn2r22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01024:Vmn2r22 APN 6 123,615,012 (GRCm39) missense probably damaging 1.00
IGL01764:Vmn2r22 APN 6 123,627,379 (GRCm39) critical splice donor site probably null
IGL02037:Vmn2r22 APN 6 123,626,026 (GRCm39) missense probably damaging 1.00
IGL02183:Vmn2r22 APN 6 123,614,963 (GRCm39) missense probably damaging 1.00
IGL02440:Vmn2r22 APN 6 123,614,364 (GRCm39) missense probably benign 0.00
IGL02663:Vmn2r22 APN 6 123,626,117 (GRCm39) missense probably benign 0.11
IGL03101:Vmn2r22 APN 6 123,614,295 (GRCm39) missense probably benign 0.09
R0266:Vmn2r22 UTSW 6 123,614,363 (GRCm39) missense probably damaging 0.99
R0348:Vmn2r22 UTSW 6 123,614,684 (GRCm39) missense probably damaging 1.00
R0780:Vmn2r22 UTSW 6 123,614,933 (GRCm39) missense probably damaging 1.00
R0849:Vmn2r22 UTSW 6 123,614,363 (GRCm39) missense probably damaging 0.99
R1074:Vmn2r22 UTSW 6 123,626,217 (GRCm39) missense probably benign 0.02
R1456:Vmn2r22 UTSW 6 123,614,624 (GRCm39) missense possibly damaging 0.86
R1719:Vmn2r22 UTSW 6 123,614,802 (GRCm39) missense possibly damaging 0.68
R1989:Vmn2r22 UTSW 6 123,614,500 (GRCm39) missense probably damaging 1.00
R2928:Vmn2r22 UTSW 6 123,614,402 (GRCm39) missense probably damaging 0.96
R2939:Vmn2r22 UTSW 6 123,614,594 (GRCm39) missense probably damaging 0.99
R3727:Vmn2r22 UTSW 6 123,627,584 (GRCm39) missense possibly damaging 0.70
R3782:Vmn2r22 UTSW 6 123,627,591 (GRCm39) nonsense probably null
R3873:Vmn2r22 UTSW 6 123,614,339 (GRCm39) missense possibly damaging 0.68
R4344:Vmn2r22 UTSW 6 123,614,756 (GRCm39) missense probably damaging 1.00
R4407:Vmn2r22 UTSW 6 123,614,913 (GRCm39) missense probably damaging 1.00
R4428:Vmn2r22 UTSW 6 123,614,817 (GRCm39) missense possibly damaging 0.47
R4430:Vmn2r22 UTSW 6 123,614,817 (GRCm39) missense possibly damaging 0.47
R4431:Vmn2r22 UTSW 6 123,614,817 (GRCm39) missense possibly damaging 0.47
R4701:Vmn2r22 UTSW 6 123,627,428 (GRCm39) missense probably benign 0.00
R5274:Vmn2r22 UTSW 6 123,627,593 (GRCm39) start codon destroyed probably null 0.93
R5668:Vmn2r22 UTSW 6 123,614,873 (GRCm39) missense probably benign 0.06
R5776:Vmn2r22 UTSW 6 123,614,673 (GRCm39) missense probably damaging 1.00
R6416:Vmn2r22 UTSW 6 123,614,697 (GRCm39) missense probably damaging 1.00
R7788:Vmn2r22 UTSW 6 123,614,559 (GRCm39) missense not run
R8208:Vmn2r22 UTSW 6 123,614,444 (GRCm39) missense probably damaging 1.00
R8267:Vmn2r22 UTSW 6 123,615,000 (GRCm39) missense possibly damaging 0.81
R8400:Vmn2r22 UTSW 6 123,614,486 (GRCm39) nonsense probably null
R8814:Vmn2r22 UTSW 6 123,614,789 (GRCm39) missense probably damaging 0.96
R8850:Vmn2r22 UTSW 6 123,614,454 (GRCm39) missense probably damaging 1.00
R9613:Vmn2r22 UTSW 6 123,615,075 (GRCm39) missense probably damaging 0.99
Posted On 2015-04-16