Incidental Mutation 'IGL02335:Mroh7'
ID 289673
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mroh7
Ensembl Gene ENSMUSG00000047502
Gene Name maestro heat-like repeat family member 7
Synonyms Heatr8, LOC381538, Gm1027
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02335
Quality Score
Status
Chromosome 4
Chromosomal Location 106680417-106730925 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 106707782 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Leucine to Serine at position 545 (L545S)
Ref Sequence ENSEMBL: ENSMUSP00000102382 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106770] [ENSMUST00000145044]
AlphaFold A2AVR2
Predicted Effect probably damaging
Transcript: ENSMUST00000106770
AA Change: L545S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000102382
Gene: ENSMUSG00000047502
AA Change: L545S

DomainStartEndE-ValueType
low complexity region 39 61 N/A INTRINSIC
low complexity region 318 332 N/A INTRINSIC
low complexity region 563 573 N/A INTRINSIC
SCOP:d1b3ua_ 634 1218 6e-9 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134160
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135000
Predicted Effect probably benign
Transcript: ENSMUST00000145044
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145374
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5830411N06Rik A T 7: 140,296,540 (GRCm38) N526Y probably damaging Het
A4gnt C T 9: 99,620,213 (GRCm38) T142I probably benign Het
Acaca A G 11: 84,214,258 (GRCm38) T147A possibly damaging Het
Agbl3 A G 6: 34,799,750 (GRCm38) D397G probably damaging Het
Ank1 C T 8: 23,135,638 (GRCm38) T1597M possibly damaging Het
Arl4d A G 11: 101,666,929 (GRCm38) T94A possibly damaging Het
Cd22 A G 7: 30,876,134 (GRCm38) I161T probably damaging Het
Clcn7 C T 17: 25,146,847 (GRCm38) L166F probably benign Het
Cnbd1 G T 4: 19,055,095 (GRCm38) N110K possibly damaging Het
Col14a1 A T 15: 55,463,769 (GRCm38) probably benign Het
Col6a6 C T 9: 105,784,101 (GRCm38) V270M probably damaging Het
Cox8b C A 7: 140,899,077 (GRCm38) G42W probably damaging Het
Csn1s1 A T 5: 87,680,845 (GRCm38) D275V probably benign Het
Cubn T A 2: 13,427,834 (GRCm38) probably null Het
Dctn2 T C 10: 127,275,821 (GRCm38) probably benign Het
Dnm1l A G 16: 16,342,740 (GRCm38) probably benign Het
Dpp4 T C 2: 62,334,644 (GRCm38) E687G probably benign Het
Fbxw20 T C 9: 109,223,309 (GRCm38) K249E possibly damaging Het
Fhl2 C T 1: 43,128,390 (GRCm38) W181* probably null Het
G2e3 T A 12: 51,369,158 (GRCm38) M559K probably benign Het
Gdap1l1 A T 2: 163,447,595 (GRCm38) Y160F possibly damaging Het
Gm1110 T C 9: 26,881,763 (GRCm38) I572M probably benign Het
Gm5538 G A 3: 59,743,605 (GRCm38) M49I probably benign Het
Gpatch2l T A 12: 86,256,937 (GRCm38) probably benign Het
Kcnq4 A G 4: 120,715,854 (GRCm38) L250P probably damaging Het
Lamc2 A T 1: 153,166,216 (GRCm38) N57K probably benign Het
Lingo1 A G 9: 56,620,081 (GRCm38) L408P probably damaging Het
Mmrn1 A T 6: 60,977,147 (GRCm38) N804I possibly damaging Het
Nup188 T A 2: 30,323,636 (GRCm38) probably null Het
Olfr1442 T C 19: 12,674,238 (GRCm38) I11T probably damaging Het
Olfr1494 A G 19: 13,749,934 (GRCm38) D276G probably benign Het
Olfr96 A G 17: 37,225,326 (GRCm38) N67S probably damaging Het
Pls1 A T 9: 95,784,183 (GRCm38) N138K probably benign Het
Prkch C A 12: 73,702,512 (GRCm38) N345K probably benign Het
Reps1 T C 10: 18,056,117 (GRCm38) probably null Het
Rrp7a T C 15: 83,122,691 (GRCm38) E15G probably benign Het
Scn1a T A 2: 66,277,661 (GRCm38) T1557S possibly damaging Het
Smtn T C 11: 3,526,215 (GRCm38) E602G probably damaging Het
Syvn1 T C 19: 6,050,093 (GRCm38) probably null Het
Tbxas1 A G 6: 39,023,080 (GRCm38) D267G probably damaging Het
Topbp1 A G 9: 103,328,523 (GRCm38) N787D probably damaging Het
Vmn2r22 T G 6: 123,638,092 (GRCm38) S180R probably damaging Het
Zfp345 T A 2: 150,474,543 (GRCm38) E48D possibly damaging Het
Zfp608 G A 18: 54,897,437 (GRCm38) Q1144* probably null Het
Zfp936 T A 7: 43,187,267 (GRCm38) L34Q probably damaging Het
Other mutations in Mroh7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01722:Mroh7 APN 4 106,703,161 (GRCm38) missense probably benign 0.00
IGL01729:Mroh7 APN 4 106,704,205 (GRCm38) missense possibly damaging 0.66
IGL01834:Mroh7 APN 4 106,680,874 (GRCm38) missense probably benign 0.00
IGL02003:Mroh7 APN 4 106,702,529 (GRCm38) missense probably damaging 0.96
IGL02135:Mroh7 APN 4 106,702,510 (GRCm38) missense probably damaging 1.00
IGL02532:Mroh7 APN 4 106,720,591 (GRCm38) missense probably benign 0.04
IGL02896:Mroh7 APN 4 106,699,816 (GRCm38) missense possibly damaging 0.94
IGL03066:Mroh7 APN 4 106,692,398 (GRCm38) missense possibly damaging 0.85
IGL03298:Mroh7 APN 4 106,714,091 (GRCm38) nonsense probably null
holy UTSW 4 106,709,955 (GRCm38) splice site probably null
moley UTSW 4 106,694,312 (GRCm38) splice site probably null
P0016:Mroh7 UTSW 4 106,707,857 (GRCm38) critical splice acceptor site probably null
R0019:Mroh7 UTSW 4 106,721,426 (GRCm38) missense probably benign 0.07
R0094:Mroh7 UTSW 4 106,703,184 (GRCm38) missense probably damaging 0.98
R0105:Mroh7 UTSW 4 106,711,270 (GRCm38) missense possibly damaging 0.49
R0105:Mroh7 UTSW 4 106,711,270 (GRCm38) missense possibly damaging 0.49
R0515:Mroh7 UTSW 4 106,691,664 (GRCm38) missense probably benign 0.01
R0828:Mroh7 UTSW 4 106,699,876 (GRCm38) missense probably damaging 0.99
R0831:Mroh7 UTSW 4 106,680,793 (GRCm38) missense possibly damaging 0.92
R1107:Mroh7 UTSW 4 106,707,594 (GRCm38) splice site probably null
R1301:Mroh7 UTSW 4 106,720,495 (GRCm38) missense probably damaging 0.99
R1456:Mroh7 UTSW 4 106,695,141 (GRCm38) splice site probably benign
R1491:Mroh7 UTSW 4 106,703,058 (GRCm38) missense probably benign 0.11
R1540:Mroh7 UTSW 4 106,703,076 (GRCm38) missense probably benign 0.11
R1560:Mroh7 UTSW 4 106,711,254 (GRCm38) missense possibly damaging 0.78
R1645:Mroh7 UTSW 4 106,720,668 (GRCm38) missense probably benign 0.19
R1804:Mroh7 UTSW 4 106,694,392 (GRCm38) missense possibly damaging 0.76
R2162:Mroh7 UTSW 4 106,700,181 (GRCm38) missense probably damaging 0.96
R2265:Mroh7 UTSW 4 106,720,927 (GRCm38) missense probably benign 0.01
R2866:Mroh7 UTSW 4 106,691,090 (GRCm38) missense probably damaging 1.00
R3716:Mroh7 UTSW 4 106,704,210 (GRCm38) missense probably benign 0.25
R3718:Mroh7 UTSW 4 106,704,210 (GRCm38) missense probably benign 0.25
R4530:Mroh7 UTSW 4 106,720,437 (GRCm38) missense possibly damaging 0.71
R4661:Mroh7 UTSW 4 106,691,513 (GRCm38) critical splice donor site probably null
R4706:Mroh7 UTSW 4 106,691,624 (GRCm38) missense possibly damaging 0.86
R4910:Mroh7 UTSW 4 106,709,955 (GRCm38) splice site probably null
R4965:Mroh7 UTSW 4 106,690,987 (GRCm38) missense possibly damaging 0.77
R4969:Mroh7 UTSW 4 106,680,873 (GRCm38) missense probably benign
R4971:Mroh7 UTSW 4 106,691,552 (GRCm38) missense probably benign 0.04
R5083:Mroh7 UTSW 4 106,690,318 (GRCm38) missense probably benign 0.03
R5207:Mroh7 UTSW 4 106,721,386 (GRCm38) missense probably damaging 0.97
R5364:Mroh7 UTSW 4 106,691,643 (GRCm38) missense probably benign 0.10
R5392:Mroh7 UTSW 4 106,711,251 (GRCm38) critical splice donor site probably null
R5630:Mroh7 UTSW 4 106,720,567 (GRCm38) missense possibly damaging 0.71
R5691:Mroh7 UTSW 4 106,702,618 (GRCm38) missense probably damaging 0.96
R5703:Mroh7 UTSW 4 106,708,560 (GRCm38) missense possibly damaging 0.77
R5707:Mroh7 UTSW 4 106,681,885 (GRCm38) missense possibly damaging 0.73
R5919:Mroh7 UTSW 4 106,694,312 (GRCm38) splice site probably null
R5979:Mroh7 UTSW 4 106,720,926 (GRCm38) missense probably benign 0.00
R6479:Mroh7 UTSW 4 106,703,188 (GRCm38) missense possibly damaging 0.75
R6520:Mroh7 UTSW 4 106,721,263 (GRCm38) missense probably benign 0.00
R6657:Mroh7 UTSW 4 106,702,500 (GRCm38) nonsense probably null
R6732:Mroh7 UTSW 4 106,680,713 (GRCm38) frame shift probably null
R6817:Mroh7 UTSW 4 106,714,115 (GRCm38) missense probably benign 0.00
R6980:Mroh7 UTSW 4 106,700,237 (GRCm38) missense probably benign 0.05
R7062:Mroh7 UTSW 4 106,683,980 (GRCm38) missense probably damaging 1.00
R7116:Mroh7 UTSW 4 106,711,320 (GRCm38) missense probably benign 0.07
R7134:Mroh7 UTSW 4 106,720,594 (GRCm38) missense probably damaging 0.99
R7169:Mroh7 UTSW 4 106,691,639 (GRCm38) missense probably damaging 0.99
R7419:Mroh7 UTSW 4 106,683,918 (GRCm38) missense probably benign
R7516:Mroh7 UTSW 4 106,691,119 (GRCm38) missense probably benign 0.00
R7525:Mroh7 UTSW 4 106,709,702 (GRCm38) missense probably benign 0.22
R7540:Mroh7 UTSW 4 106,720,398 (GRCm38) missense possibly damaging 0.85
R7849:Mroh7 UTSW 4 106,721,090 (GRCm38) missense probably benign
R7920:Mroh7 UTSW 4 106,707,576 (GRCm38) missense probably benign
R7998:Mroh7 UTSW 4 106,711,281 (GRCm38) missense probably benign 0.02
R8026:Mroh7 UTSW 4 106,721,437 (GRCm38) missense probably benign 0.01
R8122:Mroh7 UTSW 4 106,702,529 (GRCm38) missense probably damaging 0.96
R8249:Mroh7 UTSW 4 106,721,212 (GRCm38) missense probably benign 0.00
R9188:Mroh7 UTSW 4 106,709,592 (GRCm38) missense probably benign 0.01
Posted On 2015-04-16