Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02335:Mroh7'

289673

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mroh7

Ensembl Gene

ENSMUSG00000047502

Gene Name

maestro heat-like repeat family member 7

Synonyms

Heatr8, Gm1027, LOC381538

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02335

Quality Score

Status

Chromosome

Chromosomal Location

106537614-106588122 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 106564979 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Serine at position 545 (L545S)

Ref Sequence

ENSEMBL: ENSMUSP00000102382 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000106770] [ENSMUST00000145044]

AlphaFold

A2AVR2

Predicted Effect

probably damaging
Transcript: ENSMUST00000106770
AA Change: L545S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000102382
Gene: ENSMUSG00000047502
AA Change: L545S

Domain	Start	End	E-Value	Type
low complexity region	39	61	N/A	INTRINSIC
low complexity region	318	332	N/A	INTRINSIC
low complexity region	563	573	N/A	INTRINSIC
SCOP:d1b3ua_	634	1218	6e-9	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134160

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000135000

Predicted Effect

probably benign
Transcript: ENSMUST00000145044

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000145374

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A4gnt	C	T	9: 99,502,266 (GRCm39)	T142I	probably benign	Het
Aadacl2fm2	G	A	3: 59,651,026 (GRCm39)	M49I	probably benign	Het
Acaca	A	G	11: 84,105,084 (GRCm39)	T147A	possibly damaging	Het
Agbl3	A	G	6: 34,776,685 (GRCm39)	D397G	probably damaging	Het
Ank1	C	T	8: 23,625,654 (GRCm39)	T1597M	possibly damaging	Het
Arl4d	A	G	11: 101,557,755 (GRCm39)	T94A	possibly damaging	Het
Cd22	A	G	7: 30,575,559 (GRCm39)	I161T	probably damaging	Het
Clcn7	C	T	17: 25,365,821 (GRCm39)	L166F	probably benign	Het
Cnbd1	G	T	4: 19,055,095 (GRCm39)	N110K	possibly damaging	Het
Col14a1	A	T	15: 55,327,165 (GRCm39)		probably benign	Het
Col6a6	C	T	9: 105,661,300 (GRCm39)	V270M	probably damaging	Het
Cox8b	C	A	7: 140,478,990 (GRCm39)	G42W	probably damaging	Het
Csn1s1	A	T	5: 87,828,704 (GRCm39)	D275V	probably benign	Het
Cubn	T	A	2: 13,432,645 (GRCm39)		probably null	Het
Dctn2	T	C	10: 127,111,690 (GRCm39)		probably benign	Het
Dnm1l	A	G	16: 16,160,604 (GRCm39)		probably benign	Het
Dpp4	T	C	2: 62,164,988 (GRCm39)	E687G	probably benign	Het
Fbxw20	T	C	9: 109,052,377 (GRCm39)	K249E	possibly damaging	Het
Fhl2	C	T	1: 43,167,550 (GRCm39)	W181*	probably null	Het
G2e3	T	A	12: 51,415,941 (GRCm39)	M559K	probably benign	Het
Gdap1l1	A	T	2: 163,289,515 (GRCm39)	Y160F	possibly damaging	Het
Gm1110	T	C	9: 26,793,059 (GRCm39)	I572M	probably benign	Het
Gpatch2l	T	A	12: 86,303,711 (GRCm39)		probably benign	Het
Kcnq4	A	G	4: 120,573,051 (GRCm39)	L250P	probably damaging	Het
Lamc2	A	T	1: 153,041,962 (GRCm39)	N57K	probably benign	Het
Lingo1	A	G	9: 56,527,365 (GRCm39)	L408P	probably damaging	Het
Mmrn1	A	T	6: 60,954,131 (GRCm39)	N804I	possibly damaging	Het
Nup188	T	A	2: 30,213,648 (GRCm39)		probably null	Het
Or10q1	A	G	19: 13,727,298 (GRCm39)	D276G	probably benign	Het
Or11a4	A	G	17: 37,536,217 (GRCm39)	N67S	probably damaging	Het
Or5b94	T	C	19: 12,651,602 (GRCm39)	I11T	probably damaging	Het
Pls1	A	T	9: 95,666,236 (GRCm39)	N138K	probably benign	Het
Prkch	C	A	12: 73,749,286 (GRCm39)	N345K	probably benign	Het
Reps1	T	C	10: 17,931,865 (GRCm39)		probably null	Het
Rrp7a	T	C	15: 83,006,892 (GRCm39)	E15G	probably benign	Het
Scart2	A	T	7: 139,876,453 (GRCm39)	N526Y	probably damaging	Het
Scn1a	T	A	2: 66,108,005 (GRCm39)	T1557S	possibly damaging	Het
Smtn	T	C	11: 3,476,215 (GRCm39)	E602G	probably damaging	Het
Syvn1	T	C	19: 6,100,123 (GRCm39)		probably null	Het
Tbxas1	A	G	6: 39,000,014 (GRCm39)	D267G	probably damaging	Het
Topbp1	A	G	9: 103,205,722 (GRCm39)	N787D	probably damaging	Het
Vmn2r22	T	G	6: 123,615,051 (GRCm39)	S180R	probably damaging	Het
Zfp345	T	A	2: 150,316,463 (GRCm39)	E48D	possibly damaging	Het
Zfp608	G	A	18: 55,030,509 (GRCm39)	Q1144*	probably null	Het
Zfp936	T	A	7: 42,836,691 (GRCm39)	L34Q	probably damaging	Het

Other mutations in Mroh7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01722:Mroh7	APN	4	106,560,358 (GRCm39)	missense	probably benign	0.00
IGL01729:Mroh7	APN	4	106,561,402 (GRCm39)	missense	possibly damaging	0.66
IGL01834:Mroh7	APN	4	106,538,071 (GRCm39)	missense	probably benign	0.00
IGL02003:Mroh7	APN	4	106,559,726 (GRCm39)	missense	probably damaging	0.96
IGL02135:Mroh7	APN	4	106,559,707 (GRCm39)	missense	probably damaging	1.00
IGL02532:Mroh7	APN	4	106,577,788 (GRCm39)	missense	probably benign	0.04
IGL02896:Mroh7	APN	4	106,557,013 (GRCm39)	missense	possibly damaging	0.94
IGL03066:Mroh7	APN	4	106,549,595 (GRCm39)	missense	possibly damaging	0.85
IGL03298:Mroh7	APN	4	106,571,288 (GRCm39)	nonsense	probably null
holy	UTSW	4	106,567,152 (GRCm39)	splice site	probably null
moley	UTSW	4	106,551,509 (GRCm39)	splice site	probably null
P0016:Mroh7	UTSW	4	106,565,054 (GRCm39)	critical splice acceptor site	probably null
R0019:Mroh7	UTSW	4	106,578,623 (GRCm39)	missense	probably benign	0.07
R0094:Mroh7	UTSW	4	106,560,381 (GRCm39)	missense	probably damaging	0.98
R0105:Mroh7	UTSW	4	106,568,467 (GRCm39)	missense	possibly damaging	0.49
R0105:Mroh7	UTSW	4	106,568,467 (GRCm39)	missense	possibly damaging	0.49
R0515:Mroh7	UTSW	4	106,548,861 (GRCm39)	missense	probably benign	0.01
R0828:Mroh7	UTSW	4	106,557,073 (GRCm39)	missense	probably damaging	0.99
R0831:Mroh7	UTSW	4	106,537,990 (GRCm39)	missense	possibly damaging	0.92
R1107:Mroh7	UTSW	4	106,564,791 (GRCm39)	splice site	probably null
R1301:Mroh7	UTSW	4	106,577,692 (GRCm39)	missense	probably damaging	0.99
R1456:Mroh7	UTSW	4	106,552,338 (GRCm39)	splice site	probably benign
R1491:Mroh7	UTSW	4	106,560,255 (GRCm39)	missense	probably benign	0.11
R1540:Mroh7	UTSW	4	106,560,273 (GRCm39)	missense	probably benign	0.11
R1560:Mroh7	UTSW	4	106,568,451 (GRCm39)	missense	possibly damaging	0.78
R1645:Mroh7	UTSW	4	106,577,865 (GRCm39)	missense	probably benign	0.19
R1804:Mroh7	UTSW	4	106,551,589 (GRCm39)	missense	possibly damaging	0.76
R2162:Mroh7	UTSW	4	106,557,378 (GRCm39)	missense	probably damaging	0.96
R2265:Mroh7	UTSW	4	106,578,124 (GRCm39)	missense	probably benign	0.01
R2866:Mroh7	UTSW	4	106,548,287 (GRCm39)	missense	probably damaging	1.00
R3716:Mroh7	UTSW	4	106,561,407 (GRCm39)	missense	probably benign	0.25
R3718:Mroh7	UTSW	4	106,561,407 (GRCm39)	missense	probably benign	0.25
R4530:Mroh7	UTSW	4	106,577,634 (GRCm39)	missense	possibly damaging	0.71
R4661:Mroh7	UTSW	4	106,548,710 (GRCm39)	critical splice donor site	probably null
R4706:Mroh7	UTSW	4	106,548,821 (GRCm39)	missense	possibly damaging	0.86
R4910:Mroh7	UTSW	4	106,567,152 (GRCm39)	splice site	probably null
R4965:Mroh7	UTSW	4	106,548,184 (GRCm39)	missense	possibly damaging	0.77
R4969:Mroh7	UTSW	4	106,538,070 (GRCm39)	missense	probably benign
R4971:Mroh7	UTSW	4	106,548,749 (GRCm39)	missense	probably benign	0.04
R5083:Mroh7	UTSW	4	106,547,515 (GRCm39)	missense	probably benign	0.03
R5207:Mroh7	UTSW	4	106,578,583 (GRCm39)	missense	probably damaging	0.97
R5364:Mroh7	UTSW	4	106,548,840 (GRCm39)	missense	probably benign	0.10
R5392:Mroh7	UTSW	4	106,568,448 (GRCm39)	critical splice donor site	probably null
R5630:Mroh7	UTSW	4	106,577,764 (GRCm39)	missense	possibly damaging	0.71
R5691:Mroh7	UTSW	4	106,559,815 (GRCm39)	missense	probably damaging	0.96
R5703:Mroh7	UTSW	4	106,565,757 (GRCm39)	missense	possibly damaging	0.77
R5707:Mroh7	UTSW	4	106,539,082 (GRCm39)	missense	possibly damaging	0.73
R5919:Mroh7	UTSW	4	106,551,509 (GRCm39)	splice site	probably null
R5979:Mroh7	UTSW	4	106,578,123 (GRCm39)	missense	probably benign	0.00
R6479:Mroh7	UTSW	4	106,560,385 (GRCm39)	missense	possibly damaging	0.75
R6520:Mroh7	UTSW	4	106,578,460 (GRCm39)	missense	probably benign	0.00
R6657:Mroh7	UTSW	4	106,559,697 (GRCm39)	nonsense	probably null
R6732:Mroh7	UTSW	4	106,537,910 (GRCm39)	frame shift	probably null
R6817:Mroh7	UTSW	4	106,571,312 (GRCm39)	missense	probably benign	0.00
R6980:Mroh7	UTSW	4	106,557,434 (GRCm39)	missense	probably benign	0.05
R7062:Mroh7	UTSW	4	106,541,177 (GRCm39)	missense	probably damaging	1.00
R7116:Mroh7	UTSW	4	106,568,517 (GRCm39)	missense	probably benign	0.07
R7134:Mroh7	UTSW	4	106,577,791 (GRCm39)	missense	probably damaging	0.99
R7169:Mroh7	UTSW	4	106,548,836 (GRCm39)	missense	probably damaging	0.99
R7419:Mroh7	UTSW	4	106,541,115 (GRCm39)	missense	probably benign
R7516:Mroh7	UTSW	4	106,548,316 (GRCm39)	missense	probably benign	0.00
R7525:Mroh7	UTSW	4	106,566,899 (GRCm39)	missense	probably benign	0.22
R7540:Mroh7	UTSW	4	106,577,595 (GRCm39)	missense	possibly damaging	0.85
R7849:Mroh7	UTSW	4	106,578,287 (GRCm39)	missense	probably benign
R7920:Mroh7	UTSW	4	106,564,773 (GRCm39)	missense	probably benign
R7998:Mroh7	UTSW	4	106,568,478 (GRCm39)	missense	probably benign	0.02
R8026:Mroh7	UTSW	4	106,578,634 (GRCm39)	missense	probably benign	0.01
R8122:Mroh7	UTSW	4	106,559,726 (GRCm39)	missense	probably damaging	0.96
R8249:Mroh7	UTSW	4	106,578,409 (GRCm39)	missense	probably benign	0.00
R9188:Mroh7	UTSW	4	106,566,789 (GRCm39)	missense	probably benign	0.01

Posted On

2015-04-16