Incidental Mutation 'IGL02335:Zfp345'
ID 289680
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp345
Ensembl Gene ENSMUSG00000074731
Gene Name zinc finger protein 345
Synonyms OTTMUSG00000015743
Accession Numbers
Essential gene? Probably non essential (E-score: 0.150) question?
Stock # IGL02335
Quality Score
Status
Chromosome 2
Chromosomal Location 150312911-150326983 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 150316463 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Aspartic acid at position 48 (E48D)
Ref Sequence ENSEMBL: ENSMUSP00000105540 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109914]
AlphaFold A2AQA1
Predicted Effect possibly damaging
Transcript: ENSMUST00000109914
AA Change: E48D

PolyPhen 2 Score 0.922 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000105540
Gene: ENSMUSG00000074731
AA Change: E48D

DomainStartEndE-ValueType
KRAB 4 66 9.5e-20 SMART
ZnF_C2H2 103 125 2e-2 SMART
ZnF_C2H2 131 153 2.9e-6 SMART
ZnF_C2H2 159 181 4.1e-3 SMART
ZnF_C2H2 215 237 2.6e-7 SMART
ZnF_C2H2 243 265 1.6e-5 SMART
ZnF_C2H2 271 293 4e-7 SMART
ZnF_C2H2 299 321 1.1e-5 SMART
ZnF_C2H2 327 349 5.9e-7 SMART
ZnF_C2H2 365 387 4.4e-7 SMART
ZnF_C2H2 393 415 7.3e-6 SMART
ZnF_C2H2 421 443 2.7e-5 SMART
ZnF_C2H2 449 471 1.5e-4 SMART
ZnF_C2H2 477 499 1.3e-5 SMART
ZnF_C2H2 505 527 5.1e-6 SMART
ZnF_C2H2 533 555 9.2e-7 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000117906
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A4gnt C T 9: 99,502,266 (GRCm39) T142I probably benign Het
Aadacl2fm2 G A 3: 59,651,026 (GRCm39) M49I probably benign Het
Acaca A G 11: 84,105,084 (GRCm39) T147A possibly damaging Het
Agbl3 A G 6: 34,776,685 (GRCm39) D397G probably damaging Het
Ank1 C T 8: 23,625,654 (GRCm39) T1597M possibly damaging Het
Arl4d A G 11: 101,557,755 (GRCm39) T94A possibly damaging Het
Cd22 A G 7: 30,575,559 (GRCm39) I161T probably damaging Het
Clcn7 C T 17: 25,365,821 (GRCm39) L166F probably benign Het
Cnbd1 G T 4: 19,055,095 (GRCm39) N110K possibly damaging Het
Col14a1 A T 15: 55,327,165 (GRCm39) probably benign Het
Col6a6 C T 9: 105,661,300 (GRCm39) V270M probably damaging Het
Cox8b C A 7: 140,478,990 (GRCm39) G42W probably damaging Het
Csn1s1 A T 5: 87,828,704 (GRCm39) D275V probably benign Het
Cubn T A 2: 13,432,645 (GRCm39) probably null Het
Dctn2 T C 10: 127,111,690 (GRCm39) probably benign Het
Dnm1l A G 16: 16,160,604 (GRCm39) probably benign Het
Dpp4 T C 2: 62,164,988 (GRCm39) E687G probably benign Het
Fbxw20 T C 9: 109,052,377 (GRCm39) K249E possibly damaging Het
Fhl2 C T 1: 43,167,550 (GRCm39) W181* probably null Het
G2e3 T A 12: 51,415,941 (GRCm39) M559K probably benign Het
Gdap1l1 A T 2: 163,289,515 (GRCm39) Y160F possibly damaging Het
Gm1110 T C 9: 26,793,059 (GRCm39) I572M probably benign Het
Gpatch2l T A 12: 86,303,711 (GRCm39) probably benign Het
Kcnq4 A G 4: 120,573,051 (GRCm39) L250P probably damaging Het
Lamc2 A T 1: 153,041,962 (GRCm39) N57K probably benign Het
Lingo1 A G 9: 56,527,365 (GRCm39) L408P probably damaging Het
Mmrn1 A T 6: 60,954,131 (GRCm39) N804I possibly damaging Het
Mroh7 A G 4: 106,564,979 (GRCm39) L545S probably damaging Het
Nup188 T A 2: 30,213,648 (GRCm39) probably null Het
Or10q1 A G 19: 13,727,298 (GRCm39) D276G probably benign Het
Or11a4 A G 17: 37,536,217 (GRCm39) N67S probably damaging Het
Or5b94 T C 19: 12,651,602 (GRCm39) I11T probably damaging Het
Pls1 A T 9: 95,666,236 (GRCm39) N138K probably benign Het
Prkch C A 12: 73,749,286 (GRCm39) N345K probably benign Het
Reps1 T C 10: 17,931,865 (GRCm39) probably null Het
Rrp7a T C 15: 83,006,892 (GRCm39) E15G probably benign Het
Scart2 A T 7: 139,876,453 (GRCm39) N526Y probably damaging Het
Scn1a T A 2: 66,108,005 (GRCm39) T1557S possibly damaging Het
Smtn T C 11: 3,476,215 (GRCm39) E602G probably damaging Het
Syvn1 T C 19: 6,100,123 (GRCm39) probably null Het
Tbxas1 A G 6: 39,000,014 (GRCm39) D267G probably damaging Het
Topbp1 A G 9: 103,205,722 (GRCm39) N787D probably damaging Het
Vmn2r22 T G 6: 123,615,051 (GRCm39) S180R probably damaging Het
Zfp608 G A 18: 55,030,509 (GRCm39) Q1144* probably null Het
Zfp936 T A 7: 42,836,691 (GRCm39) L34Q probably damaging Het
Other mutations in Zfp345
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00833:Zfp345 APN 2 150,314,649 (GRCm39) missense probably damaging 1.00
IGL00846:Zfp345 APN 2 150,314,538 (GRCm39) missense possibly damaging 0.76
IGL01020:Zfp345 APN 2 150,314,967 (GRCm39) missense possibly damaging 0.68
IGL01931:Zfp345 APN 2 150,315,270 (GRCm39) missense probably benign 0.38
IGL02237:Zfp345 APN 2 150,316,805 (GRCm39) splice site probably benign
IGL02592:Zfp345 APN 2 150,315,229 (GRCm39) missense probably benign 0.36
IGL02736:Zfp345 APN 2 150,316,474 (GRCm39) missense probably damaging 0.99
R0095:Zfp345 UTSW 2 150,314,220 (GRCm39) missense probably damaging 1.00
R0096:Zfp345 UTSW 2 150,314,220 (GRCm39) missense probably damaging 1.00
R0143:Zfp345 UTSW 2 150,314,475 (GRCm39) missense probably benign
R0371:Zfp345 UTSW 2 150,313,983 (GRCm39) missense possibly damaging 0.81
R0412:Zfp345 UTSW 2 150,315,323 (GRCm39) missense probably benign 0.00
R0415:Zfp345 UTSW 2 150,316,479 (GRCm39) splice site probably benign
R0420:Zfp345 UTSW 2 150,315,163 (GRCm39) missense possibly damaging 0.74
R0697:Zfp345 UTSW 2 150,314,829 (GRCm39) missense probably benign 0.13
R0799:Zfp345 UTSW 2 150,314,271 (GRCm39) missense probably benign 0.27
R1881:Zfp345 UTSW 2 150,314,275 (GRCm39) missense probably damaging 1.00
R1954:Zfp345 UTSW 2 150,316,741 (GRCm39) missense probably damaging 1.00
R2004:Zfp345 UTSW 2 150,314,038 (GRCm39) missense possibly damaging 0.90
R2152:Zfp345 UTSW 2 150,314,578 (GRCm39) missense probably benign 0.00
R2153:Zfp345 UTSW 2 150,314,578 (GRCm39) missense probably benign 0.00
R3051:Zfp345 UTSW 2 150,316,772 (GRCm39) missense probably benign 0.07
R3880:Zfp345 UTSW 2 150,314,075 (GRCm39) missense possibly damaging 0.91
R3939:Zfp345 UTSW 2 150,314,473 (GRCm39) missense probably damaging 1.00
R4801:Zfp345 UTSW 2 150,315,228 (GRCm39) missense possibly damaging 0.91
R4802:Zfp345 UTSW 2 150,315,228 (GRCm39) missense possibly damaging 0.91
R4897:Zfp345 UTSW 2 150,314,608 (GRCm39) missense probably benign 0.05
R5606:Zfp345 UTSW 2 150,316,788 (GRCm39) nonsense probably null
R6009:Zfp345 UTSW 2 150,314,437 (GRCm39) missense probably damaging 1.00
R6191:Zfp345 UTSW 2 150,315,010 (GRCm39) missense probably benign 0.11
R6194:Zfp345 UTSW 2 150,314,551 (GRCm39) missense probably damaging 1.00
R6782:Zfp345 UTSW 2 150,315,274 (GRCm39) missense probably damaging 0.97
R6932:Zfp345 UTSW 2 150,315,331 (GRCm39) missense probably damaging 0.99
R7356:Zfp345 UTSW 2 150,314,209 (GRCm39) missense probably damaging 1.00
R7980:Zfp345 UTSW 2 150,314,723 (GRCm39) nonsense probably null
R8387:Zfp345 UTSW 2 150,314,740 (GRCm39) missense probably damaging 0.96
R8515:Zfp345 UTSW 2 150,314,348 (GRCm39) missense probably benign 0.01
R8940:Zfp345 UTSW 2 150,314,277 (GRCm39) missense probably benign 0.40
R9038:Zfp345 UTSW 2 150,313,864 (GRCm39) missense probably benign 0.02
R9383:Zfp345 UTSW 2 150,314,503 (GRCm39) missense possibly damaging 0.89
R9480:Zfp345 UTSW 2 150,315,212 (GRCm39) nonsense probably null
R9723:Zfp345 UTSW 2 150,314,189 (GRCm39) nonsense probably null
Posted On 2015-04-16