Incidental Mutation 'IGL02335:Lingo1'
ID289682
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lingo1
Ensembl Gene ENSMUSG00000049556
Gene Nameleucine rich repeat and Ig domain containing 1
SynonymsLINGO-1, LERN1, Lrrn6a, UNQ201, 4930471K13Rik
Accession Numbers

Genbank: NM_181074; MGI: 1915522

Is this an essential gene? Possibly non essential (E-score: 0.265) question?
Stock #IGL02335
Quality Score
Status
Chromosome9
Chromosomal Location56618475-56796468 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 56620081 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Proline at position 408 (L408P)
Ref Sequence ENSEMBL: ENSMUSP00000148179 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053568] [ENSMUST00000114247] [ENSMUST00000114256] [ENSMUST00000210032]
Predicted Effect probably damaging
Transcript: ENSMUST00000053568
AA Change: L408P

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000059050
Gene: ENSMUSG00000049556
AA Change: L408P

DomainStartEndE-ValueType
low complexity region 21 32 N/A INTRINSIC
LRRNT 35 69 1.6e-3 SMART
LRR 88 111 6.22e0 SMART
LRR_TYP 112 135 5.81e-2 SMART
LRR 136 159 6.57e-1 SMART
LRR 160 183 3.02e0 SMART
LRR 184 207 1.51e0 SMART
LRR 208 231 1.81e2 SMART
LRR 280 303 8.26e1 SMART
LRR 304 327 9.24e1 SMART
LRR 328 351 1.43e-1 SMART
LRRCT 363 416 4.15e-2 SMART
IGc2 431 498 1.58e-10 SMART
transmembrane domain 554 576 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000114247
AA Change: L408P

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000109885
Gene: ENSMUSG00000049556
AA Change: L408P

DomainStartEndE-ValueType
low complexity region 21 32 N/A INTRINSIC
LRRNT 35 69 1.6e-3 SMART
LRR 88 111 6.22e0 SMART
LRR_TYP 112 135 5.81e-2 SMART
LRR 136 159 6.57e-1 SMART
LRR 160 183 3.02e0 SMART
LRR 184 207 1.51e0 SMART
LRR 208 231 1.81e2 SMART
LRR 280 303 8.26e1 SMART
LRR 304 327 9.24e1 SMART
LRR 328 351 1.43e-1 SMART
LRRCT 363 416 4.15e-2 SMART
IGc2 431 498 1.58e-10 SMART
transmembrane domain 554 576 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000114256
AA Change: L414P

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000109894
Gene: ENSMUSG00000049556
AA Change: L414P

DomainStartEndE-ValueType
low complexity region 27 38 N/A INTRINSIC
LRRNT 41 75 1.6e-3 SMART
LRR 94 117 6.22e0 SMART
LRR_TYP 118 141 5.81e-2 SMART
LRR 142 165 6.57e-1 SMART
LRR 166 189 3.02e0 SMART
LRR 190 213 1.51e0 SMART
LRR 214 237 1.81e2 SMART
LRR 286 309 8.26e1 SMART
LRR 310 333 9.24e1 SMART
LRR 334 357 1.43e-1 SMART
LRRCT 369 422 4.15e-2 SMART
IGc2 437 504 1.58e-10 SMART
transmembrane domain 560 582 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000210032
AA Change: L408P

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit early-onset CNS myelination. [provided by MGI curators]
Allele List at MGI

All alleles(1) : Targeted, knock-out(1)

Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5830411N06Rik A T 7: 140,296,540 N526Y probably damaging Het
A4gnt C T 9: 99,620,213 T142I probably benign Het
Acaca A G 11: 84,214,258 T147A possibly damaging Het
Agbl3 A G 6: 34,799,750 D397G probably damaging Het
Ank1 C T 8: 23,135,638 T1597M possibly damaging Het
Arl4d A G 11: 101,666,929 T94A possibly damaging Het
Cd22 A G 7: 30,876,134 I161T probably damaging Het
Clcn7 C T 17: 25,146,847 L166F probably benign Het
Cnbd1 G T 4: 19,055,095 N110K possibly damaging Het
Col14a1 A T 15: 55,463,769 probably benign Het
Col6a6 C T 9: 105,784,101 V270M probably damaging Het
Cox8b C A 7: 140,899,077 G42W probably damaging Het
Csn1s1 A T 5: 87,680,845 D275V probably benign Het
Cubn T A 2: 13,427,834 probably null Het
Dctn2 T C 10: 127,275,821 probably benign Het
Dnm1l A G 16: 16,342,740 probably benign Het
Dpp4 T C 2: 62,334,644 E687G probably benign Het
Fbxw20 T C 9: 109,223,309 K249E possibly damaging Het
Fhl2 C T 1: 43,128,390 W181* probably null Het
G2e3 T A 12: 51,369,158 M559K probably benign Het
Gdap1l1 A T 2: 163,447,595 Y160F possibly damaging Het
Gm1110 T C 9: 26,881,763 I572M probably benign Het
Gm5538 G A 3: 59,743,605 M49I probably benign Het
Gpatch2l T A 12: 86,256,937 probably benign Het
Kcnq4 A G 4: 120,715,854 L250P probably damaging Het
Lamc2 A T 1: 153,166,216 N57K probably benign Het
Mmrn1 A T 6: 60,977,147 N804I possibly damaging Het
Mroh7 A G 4: 106,707,782 L545S probably damaging Het
Nup188 T A 2: 30,323,636 probably null Het
Olfr1442 T C 19: 12,674,238 I11T probably damaging Het
Olfr1494 A G 19: 13,749,934 D276G probably benign Het
Olfr96 A G 17: 37,225,326 N67S probably damaging Het
Pls1 A T 9: 95,784,183 N138K probably benign Het
Prkch C A 12: 73,702,512 N345K probably benign Het
Reps1 T C 10: 18,056,117 probably null Het
Rrp7a T C 15: 83,122,691 E15G probably benign Het
Scn1a T A 2: 66,277,661 T1557S possibly damaging Het
Smtn T C 11: 3,526,215 E602G probably damaging Het
Syvn1 T C 19: 6,050,093 probably null Het
Tbxas1 A G 6: 39,023,080 D267G probably damaging Het
Topbp1 A G 9: 103,328,523 N787D probably damaging Het
Vmn2r22 T G 6: 123,638,092 S180R probably damaging Het
Zfp345 T A 2: 150,474,543 E48D possibly damaging Het
Zfp608 G A 18: 54,897,437 Q1144* probably null Het
Zfp936 T A 7: 43,187,267 L34Q probably damaging Het
Other mutations in Lingo1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01648:Lingo1 APN 9 56619827 missense probably damaging 1.00
IGL03093:Lingo1 APN 9 56619464 missense possibly damaging 0.90
3-1:Lingo1 UTSW 9 56620420 missense probably benign 0.02
R1840:Lingo1 UTSW 9 56620558 missense probably benign 0.38
R1932:Lingo1 UTSW 9 56619650 missense possibly damaging 0.89
R2475:Lingo1 UTSW 9 56619626 missense probably benign 0.03
R3439:Lingo1 UTSW 9 56620733 missense probably benign 0.23
R3870:Lingo1 UTSW 9 56619725 missense probably benign 0.00
R4241:Lingo1 UTSW 9 56620102 missense probably damaging 1.00
R4701:Lingo1 UTSW 9 56620258 missense probably damaging 1.00
R4757:Lingo1 UTSW 9 56619925 missense probably benign 0.14
R5451:Lingo1 UTSW 9 56620427 missense probably damaging 1.00
R6190:Lingo1 UTSW 9 56619650 missense possibly damaging 0.89
R6254:Lingo1 UTSW 9 56620087 missense possibly damaging 0.55
R6836:Lingo1 UTSW 9 56619772 missense probably damaging 0.99
R6849:Lingo1 UTSW 9 56619616 missense probably damaging 1.00
R6935:Lingo1 UTSW 9 56619865 missense probably damaging 1.00
R7051:Lingo1 UTSW 9 56620183 missense probably benign 0.35
R7116:Lingo1 UTSW 9 56620627 missense probably benign 0.17
R7196:Lingo1 UTSW 9 56620619 missense probably damaging 1.00
R7470:Lingo1 UTSW 9 56620624 missense probably damaging 1.00
R7471:Lingo1 UTSW 9 56620883 nonsense probably null
R7804:Lingo1 UTSW 9 56619514 missense probably benign 0.00
X0023:Lingo1 UTSW 9 56620028 nonsense probably null
Z1177:Lingo1 UTSW 9 56620942 missense possibly damaging 0.87
Posted On2015-04-16