Incidental Mutation 'IGL02335:Or10q1'
ID 289692
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10q1
Ensembl Gene ENSMUSG00000050865
Gene Name olfactory receptor family 10 subfamily Q member 1
Synonyms MOR266-1, Olfr1494, GA_x6K02T2RE5P-4082427-4083374
Accession Numbers
Essential gene? Probably non essential (E-score: 0.081) question?
Stock # IGL02335
Quality Score
Status
Chromosome 19
Chromosomal Location 13726472-13727419 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 13727298 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 276 (D276G)
Ref Sequence ENSEMBL: ENSMUSP00000146563 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051768] [ENSMUST00000207836]
AlphaFold Q8VGP8
Predicted Effect probably benign
Transcript: ENSMUST00000051768
AA Change: D276G

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000056291
Gene: ENSMUSG00000050865
AA Change: D276G

DomainStartEndE-ValueType
low complexity region 13 27 N/A INTRINSIC
Pfam:7tm_4 35 313 3.2e-53 PFAM
Pfam:7tm_1 45 295 7.5e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207836
AA Change: D276G

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214479
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214697
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A4gnt C T 9: 99,502,266 (GRCm39) T142I probably benign Het
Aadacl2fm2 G A 3: 59,651,026 (GRCm39) M49I probably benign Het
Acaca A G 11: 84,105,084 (GRCm39) T147A possibly damaging Het
Agbl3 A G 6: 34,776,685 (GRCm39) D397G probably damaging Het
Ank1 C T 8: 23,625,654 (GRCm39) T1597M possibly damaging Het
Arl4d A G 11: 101,557,755 (GRCm39) T94A possibly damaging Het
Cd22 A G 7: 30,575,559 (GRCm39) I161T probably damaging Het
Clcn7 C T 17: 25,365,821 (GRCm39) L166F probably benign Het
Cnbd1 G T 4: 19,055,095 (GRCm39) N110K possibly damaging Het
Col14a1 A T 15: 55,327,165 (GRCm39) probably benign Het
Col6a6 C T 9: 105,661,300 (GRCm39) V270M probably damaging Het
Cox8b C A 7: 140,478,990 (GRCm39) G42W probably damaging Het
Csn1s1 A T 5: 87,828,704 (GRCm39) D275V probably benign Het
Cubn T A 2: 13,432,645 (GRCm39) probably null Het
Dctn2 T C 10: 127,111,690 (GRCm39) probably benign Het
Dnm1l A G 16: 16,160,604 (GRCm39) probably benign Het
Dpp4 T C 2: 62,164,988 (GRCm39) E687G probably benign Het
Fbxw20 T C 9: 109,052,377 (GRCm39) K249E possibly damaging Het
Fhl2 C T 1: 43,167,550 (GRCm39) W181* probably null Het
G2e3 T A 12: 51,415,941 (GRCm39) M559K probably benign Het
Gdap1l1 A T 2: 163,289,515 (GRCm39) Y160F possibly damaging Het
Gm1110 T C 9: 26,793,059 (GRCm39) I572M probably benign Het
Gpatch2l T A 12: 86,303,711 (GRCm39) probably benign Het
Kcnq4 A G 4: 120,573,051 (GRCm39) L250P probably damaging Het
Lamc2 A T 1: 153,041,962 (GRCm39) N57K probably benign Het
Lingo1 A G 9: 56,527,365 (GRCm39) L408P probably damaging Het
Mmrn1 A T 6: 60,954,131 (GRCm39) N804I possibly damaging Het
Mroh7 A G 4: 106,564,979 (GRCm39) L545S probably damaging Het
Nup188 T A 2: 30,213,648 (GRCm39) probably null Het
Or11a4 A G 17: 37,536,217 (GRCm39) N67S probably damaging Het
Or5b94 T C 19: 12,651,602 (GRCm39) I11T probably damaging Het
Pls1 A T 9: 95,666,236 (GRCm39) N138K probably benign Het
Prkch C A 12: 73,749,286 (GRCm39) N345K probably benign Het
Reps1 T C 10: 17,931,865 (GRCm39) probably null Het
Rrp7a T C 15: 83,006,892 (GRCm39) E15G probably benign Het
Scart2 A T 7: 139,876,453 (GRCm39) N526Y probably damaging Het
Scn1a T A 2: 66,108,005 (GRCm39) T1557S possibly damaging Het
Smtn T C 11: 3,476,215 (GRCm39) E602G probably damaging Het
Syvn1 T C 19: 6,100,123 (GRCm39) probably null Het
Tbxas1 A G 6: 39,000,014 (GRCm39) D267G probably damaging Het
Topbp1 A G 9: 103,205,722 (GRCm39) N787D probably damaging Het
Vmn2r22 T G 6: 123,615,051 (GRCm39) S180R probably damaging Het
Zfp345 T A 2: 150,316,463 (GRCm39) E48D possibly damaging Het
Zfp608 G A 18: 55,030,509 (GRCm39) Q1144* probably null Het
Zfp936 T A 7: 42,836,691 (GRCm39) L34Q probably damaging Het
Other mutations in Or10q1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02134:Or10q1 APN 19 13,727,165 (GRCm39) missense probably benign 0.04
IGL02388:Or10q1 APN 19 13,726,994 (GRCm39) missense possibly damaging 0.91
IGL03231:Or10q1 APN 19 13,726,749 (GRCm39) missense probably benign 0.35
R0133:Or10q1 UTSW 19 13,727,352 (GRCm39) missense probably damaging 1.00
R0142:Or10q1 UTSW 19 13,726,619 (GRCm39) missense probably benign 0.00
R0561:Or10q1 UTSW 19 13,726,662 (GRCm39) missense probably damaging 1.00
R0783:Or10q1 UTSW 19 13,727,040 (GRCm39) missense probably damaging 0.99
R1826:Or10q1 UTSW 19 13,726,711 (GRCm39) missense probably benign 0.05
R1967:Or10q1 UTSW 19 13,727,417 (GRCm39) makesense probably null
R3706:Or10q1 UTSW 19 13,726,476 (GRCm39) missense probably benign 0.42
R5417:Or10q1 UTSW 19 13,727,217 (GRCm39) missense probably benign 0.18
R6508:Or10q1 UTSW 19 13,726,718 (GRCm39) missense probably damaging 1.00
R7126:Or10q1 UTSW 19 13,726,887 (GRCm39) missense possibly damaging 0.90
R7262:Or10q1 UTSW 19 13,726,535 (GRCm39) missense probably benign 0.02
R7395:Or10q1 UTSW 19 13,726,502 (GRCm39) missense probably damaging 0.98
R7740:Or10q1 UTSW 19 13,727,328 (GRCm39) missense probably benign 0.00
R7744:Or10q1 UTSW 19 13,727,419 (GRCm39) makesense probably null
R7864:Or10q1 UTSW 19 13,726,710 (GRCm39) missense probably benign 0.03
R8495:Or10q1 UTSW 19 13,726,593 (GRCm39) missense possibly damaging 0.95
R9372:Or10q1 UTSW 19 13,727,069 (GRCm39) missense probably benign 0.14
Posted On 2015-04-16