Incidental Mutation 'IGL02335:Olfr96'
ID289696
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr96
Ensembl Gene ENSMUSG00000064121
Gene Nameolfactory receptor 96
SynonymsGA_x6K02T2PSCP-1665046-1665987, MOR121-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.105) question?
Stock #IGL02335
Quality Score
Status
Chromosome17
Chromosomal Location37220146-37226673 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 37225326 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Serine at position 67 (N67S)
Ref Sequence ENSEMBL: ENSMUSP00000151151 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078209] [ENSMUST00000213475] [ENSMUST00000214482]
Predicted Effect probably damaging
Transcript: ENSMUST00000078209
AA Change: N67S

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000077338
Gene: ENSMUSG00000064121
AA Change: N67S

DomainStartEndE-ValueType
Pfam:7tm_4 33 309 6.6e-53 PFAM
Pfam:7tm_1 43 291 6.2e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213475
AA Change: N67S

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000214482
AA Change: N67S

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5830411N06Rik A T 7: 140,296,540 N526Y probably damaging Het
A4gnt C T 9: 99,620,213 T142I probably benign Het
Acaca A G 11: 84,214,258 T147A possibly damaging Het
Agbl3 A G 6: 34,799,750 D397G probably damaging Het
Ank1 C T 8: 23,135,638 T1597M possibly damaging Het
Arl4d A G 11: 101,666,929 T94A possibly damaging Het
Cd22 A G 7: 30,876,134 I161T probably damaging Het
Clcn7 C T 17: 25,146,847 L166F probably benign Het
Cnbd1 G T 4: 19,055,095 N110K possibly damaging Het
Col14a1 A T 15: 55,463,769 probably benign Het
Col6a6 C T 9: 105,784,101 V270M probably damaging Het
Cox8b C A 7: 140,899,077 G42W probably damaging Het
Csn1s1 A T 5: 87,680,845 D275V probably benign Het
Cubn T A 2: 13,427,834 probably null Het
Dctn2 T C 10: 127,275,821 probably benign Het
Dnm1l A G 16: 16,342,740 probably benign Het
Dpp4 T C 2: 62,334,644 E687G probably benign Het
Fbxw20 T C 9: 109,223,309 K249E possibly damaging Het
Fhl2 C T 1: 43,128,390 W181* probably null Het
G2e3 T A 12: 51,369,158 M559K probably benign Het
Gdap1l1 A T 2: 163,447,595 Y160F possibly damaging Het
Gm1110 T C 9: 26,881,763 I572M probably benign Het
Gm5538 G A 3: 59,743,605 M49I probably benign Het
Gpatch2l T A 12: 86,256,937 probably benign Het
Kcnq4 A G 4: 120,715,854 L250P probably damaging Het
Lamc2 A T 1: 153,166,216 N57K probably benign Het
Lingo1 A G 9: 56,620,081 L408P probably damaging Het
Mmrn1 A T 6: 60,977,147 N804I possibly damaging Het
Mroh7 A G 4: 106,707,782 L545S probably damaging Het
Nup188 T A 2: 30,323,636 probably null Het
Olfr1442 T C 19: 12,674,238 I11T probably damaging Het
Olfr1494 A G 19: 13,749,934 D276G probably benign Het
Pls1 A T 9: 95,784,183 N138K probably benign Het
Prkch C A 12: 73,702,512 N345K probably benign Het
Reps1 T C 10: 18,056,117 probably null Het
Rrp7a T C 15: 83,122,691 E15G probably benign Het
Scn1a T A 2: 66,277,661 T1557S possibly damaging Het
Smtn T C 11: 3,526,215 E602G probably damaging Het
Syvn1 T C 19: 6,050,093 probably null Het
Tbxas1 A G 6: 39,023,080 D267G probably damaging Het
Topbp1 A G 9: 103,328,523 N787D probably damaging Het
Vmn2r22 T G 6: 123,638,092 S180R probably damaging Het
Zfp345 T A 2: 150,474,543 E48D possibly damaging Het
Zfp608 G A 18: 54,897,437 Q1144* probably null Het
Zfp936 T A 7: 43,187,267 L34Q probably damaging Het
Other mutations in Olfr96
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01868:Olfr96 APN 17 37225152 missense probably benign 0.05
IGL02151:Olfr96 APN 17 37225166 missense probably damaging 1.00
R0360:Olfr96 UTSW 17 37226043 missense possibly damaging 0.49
R0364:Olfr96 UTSW 17 37226043 missense possibly damaging 0.49
R1763:Olfr96 UTSW 17 37225430 missense probably benign 0.02
R3977:Olfr96 UTSW 17 37225158 missense probably benign 0.24
R6116:Olfr96 UTSW 17 37225568 missense probably benign 0.00
R6248:Olfr96 UTSW 17 37225560 nonsense probably null
R6378:Olfr96 UTSW 17 37225797 missense probably benign 0.21
R6518:Olfr96 UTSW 17 37225268 missense probably benign 0.05
R6614:Olfr96 UTSW 17 37225899 missense probably benign 0.01
R6798:Olfr96 UTSW 17 37225806 missense probably damaging 1.00
R6874:Olfr96 UTSW 17 37225347 missense probably benign 0.00
R7468:Olfr96 UTSW 17 37225385 missense probably benign 0.01
R7820:Olfr96 UTSW 17 37225895 missense probably benign 0.00
R7852:Olfr96 UTSW 17 37225272 missense probably benign 0.01
R7935:Olfr96 UTSW 17 37225272 missense probably benign 0.01
X0027:Olfr96 UTSW 17 37225743 missense possibly damaging 0.93
Posted On2015-04-16