Incidental Mutation 'IGL00955:Arl11'
ID 28970
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Arl11
Ensembl Gene ENSMUSG00000043157
Gene Name ADP-ribosylation factor-like 11
Synonyms ARLTS1, C730007L20Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.059) question?
Stock # IGL00955
Quality Score
Chromosome 14
Chromosomal Location 61309753-61311936 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 61311242 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Glutamine to Leucine at position 167 (Q167L)
Ref Sequence ENSEMBL: ENSMUSP00000153531 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055159] [ENSMUST00000224727]
AlphaFold Q6P3A9
Predicted Effect probably benign
Transcript: ENSMUST00000055159
AA Change: Q167L

PolyPhen 2 Score 0.218 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000055447
Gene: ENSMUSG00000043157
AA Change: Q167L

ARF 1 176 4.96e-42 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000188538
Predicted Effect probably benign
Transcript: ENSMUST00000224727
AA Change: Q167L

PolyPhen 2 Score 0.218 (Sensitivity: 0.91; Specificity: 0.88)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a tumor suppressor related to the ADP-ribosylation factor (ARF) family of proteins. The encoded protein may play a role in apoptosis in a caspase-dependent manner. Polymorphisms in this gene have been associated with some familial cancers. [provided by RefSeq, May 2010]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ces3a T A 8: 105,050,570 V175E probably damaging Het
Cherp C T 8: 72,470,194 E140K probably damaging Het
Clpx A T 9: 65,324,270 T546S probably damaging Het
Csgalnact2 A G 6: 118,129,264 L31P probably damaging Het
Cxcr1 A T 1: 74,192,220 F214L probably benign Het
Cyp2c67 T A 19: 39,643,385 T123S possibly damaging Het
Dbt G A 3: 116,546,114 G384S probably benign Het
Dzank1 G A 2: 144,490,174 T414I probably benign Het
Erich3 A G 3: 154,748,519 I641V probably benign Het
Gtf2e1 A T 16: 37,535,920 D83E possibly damaging Het
Hars2 T C 18: 36,789,357 probably benign Het
Hnrnpm C A 17: 33,649,902 R517L probably damaging Het
Kcnh2 T C 5: 24,324,966 D372G probably damaging Het
Kcnk2 A T 1: 189,243,014 I264N probably damaging Het
Kctd4 A G 14: 75,963,228 D213G probably damaging Het
Lhx9 T C 1: 138,828,680 T323A possibly damaging Het
Lilra6 C A 7: 3,911,404 probably benign Het
Meig1 T C 2: 3,409,274 D63G probably damaging Het
Mov10l1 A G 15: 88,994,989 Y184C probably damaging Het
Mrpl24 T A 3: 87,922,219 L91* probably null Het
Mup11 C T 4: 60,659,550 R175H probably benign Het
Nbea T C 3: 56,005,472 K965E possibly damaging Het
Olfr598 C A 7: 103,329,321 H278Q probably damaging Het
Papss1 G A 3: 131,599,949 E252K probably benign Het
Robo2 A T 16: 74,015,972 L278Q probably damaging Het
Sned1 A T 1: 93,274,403 I638F probably damaging Het
Spin1 T C 13: 51,144,541 probably null Het
Taar9 T C 10: 24,109,531 T2A probably benign Het
Tbc1d8b T C X: 139,725,880 probably null Het
Other mutations in Arl11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02158:Arl11 APN 14 61311038 missense probably damaging 0.99
IGL02756:Arl11 APN 14 61311086 missense probably damaging 1.00
R1755:Arl11 UTSW 14 61310944 missense probably benign
R4688:Arl11 UTSW 14 61311097 missense probably benign 0.16
R5833:Arl11 UTSW 14 61311062 missense probably damaging 1.00
R6438:Arl11 UTSW 14 61310944 missense probably benign
R7129:Arl11 UTSW 14 61310897 missense possibly damaging 0.67
R8213:Arl11 UTSW 14 61311265 missense probably benign 0.00
R8812:Arl11 UTSW 14 61310973 nonsense probably null
RF004:Arl11 UTSW 14 61310855 missense probably damaging 1.00
Z1177:Arl11 UTSW 14 61310868 frame shift probably null
Posted On 2013-04-17