Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02335:Gm5538'

289705

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm5538

Ensembl Gene

ENSMUSG00000090527

Gene Name

predicted gene 5538

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.079) question?

Stock #

IGL02335

Quality Score

Status

Chromosome

Chromosomal Location

59729790-59752333 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 59743605 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Isoleucine at position 49 (M49I)

Ref Sequence

ENSEMBL: ENSMUSP00000128877 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168156]

AlphaFold

W4VSP6

Predicted Effect

probably benign
Transcript: ENSMUST00000168156
AA Change: M49I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000128877
Gene: ENSMUSG00000090527
AA Change: M49I

Domain	Start	End	E-Value	Type
transmembrane domain	5	22	N/A	INTRINSIC
Pfam:DUF2424	70	214	9.3e-9	PFAM
Pfam:COesterase	91	236	5.4e-10	PFAM
Pfam:Abhydrolase_3	107	287	6.6e-36	PFAM
Pfam:Abhydrolase_3	271	375	1.4e-13	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5830411N06Rik	A	T	7: 140,296,540 (GRCm38)	N526Y	probably damaging	Het
A4gnt	C	T	9: 99,620,213 (GRCm38)	T142I	probably benign	Het
Acaca	A	G	11: 84,214,258 (GRCm38)	T147A	possibly damaging	Het
Agbl3	A	G	6: 34,799,750 (GRCm38)	D397G	probably damaging	Het
Ank1	C	T	8: 23,135,638 (GRCm38)	T1597M	possibly damaging	Het
Arl4d	A	G	11: 101,666,929 (GRCm38)	T94A	possibly damaging	Het
Cd22	A	G	7: 30,876,134 (GRCm38)	I161T	probably damaging	Het
Clcn7	C	T	17: 25,146,847 (GRCm38)	L166F	probably benign	Het
Cnbd1	G	T	4: 19,055,095 (GRCm38)	N110K	possibly damaging	Het
Col14a1	A	T	15: 55,463,769 (GRCm38)		probably benign	Het
Col6a6	C	T	9: 105,784,101 (GRCm38)	V270M	probably damaging	Het
Cox8b	C	A	7: 140,899,077 (GRCm38)	G42W	probably damaging	Het
Csn1s1	A	T	5: 87,680,845 (GRCm38)	D275V	probably benign	Het
Cubn	T	A	2: 13,427,834 (GRCm38)		probably null	Het
Dctn2	T	C	10: 127,275,821 (GRCm38)		probably benign	Het
Dnm1l	A	G	16: 16,342,740 (GRCm38)		probably benign	Het
Dpp4	T	C	2: 62,334,644 (GRCm38)	E687G	probably benign	Het
Fbxw20	T	C	9: 109,223,309 (GRCm38)	K249E	possibly damaging	Het
Fhl2	C	T	1: 43,128,390 (GRCm38)	W181*	probably null	Het
G2e3	T	A	12: 51,369,158 (GRCm38)	M559K	probably benign	Het
Gdap1l1	A	T	2: 163,447,595 (GRCm38)	Y160F	possibly damaging	Het
Gm1110	T	C	9: 26,881,763 (GRCm38)	I572M	probably benign	Het
Gpatch2l	T	A	12: 86,256,937 (GRCm38)		probably benign	Het
Kcnq4	A	G	4: 120,715,854 (GRCm38)	L250P	probably damaging	Het
Lamc2	A	T	1: 153,166,216 (GRCm38)	N57K	probably benign	Het
Lingo1	A	G	9: 56,620,081 (GRCm38)	L408P	probably damaging	Het
Mmrn1	A	T	6: 60,977,147 (GRCm38)	N804I	possibly damaging	Het
Mroh7	A	G	4: 106,707,782 (GRCm38)	L545S	probably damaging	Het
Nup188	T	A	2: 30,323,636 (GRCm38)		probably null	Het
Olfr1442	T	C	19: 12,674,238 (GRCm38)	I11T	probably damaging	Het
Olfr1494	A	G	19: 13,749,934 (GRCm38)	D276G	probably benign	Het
Olfr96	A	G	17: 37,225,326 (GRCm38)	N67S	probably damaging	Het
Pls1	A	T	9: 95,784,183 (GRCm38)	N138K	probably benign	Het
Prkch	C	A	12: 73,702,512 (GRCm38)	N345K	probably benign	Het
Reps1	T	C	10: 18,056,117 (GRCm38)		probably null	Het
Rrp7a	T	C	15: 83,122,691 (GRCm38)	E15G	probably benign	Het
Scn1a	T	A	2: 66,277,661 (GRCm38)	T1557S	possibly damaging	Het
Smtn	T	C	11: 3,526,215 (GRCm38)	E602G	probably damaging	Het
Syvn1	T	C	19: 6,050,093 (GRCm38)		probably null	Het
Tbxas1	A	G	6: 39,023,080 (GRCm38)	D267G	probably damaging	Het
Topbp1	A	G	9: 103,328,523 (GRCm38)	N787D	probably damaging	Het
Vmn2r22	T	G	6: 123,638,092 (GRCm38)	S180R	probably damaging	Het
Zfp345	T	A	2: 150,474,543 (GRCm38)	E48D	possibly damaging	Het
Zfp608	G	A	18: 54,897,437 (GRCm38)	Q1144*	probably null	Het
Zfp936	T	A	7: 43,187,267 (GRCm38)	L34Q	probably damaging	Het

Other mutations in Gm5538

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00426:Gm5538	APN	3	59,752,121 (GRCm38)	missense	possibly damaging	0.91
IGL00934:Gm5538	APN	3	59,752,053 (GRCm38)	missense	probably benign	0.00
IGL02709:Gm5538	APN	3	59,747,198 (GRCm38)	missense	probably damaging	1.00
IGL03114:Gm5538	APN	3	59,743,723 (GRCm38)	missense	possibly damaging	0.55
R0107:Gm5538	UTSW	3	59,752,316 (GRCm38)	missense	possibly damaging	0.78
R0591:Gm5538	UTSW	3	59,752,129 (GRCm38)	nonsense	probably null
R0850:Gm5538	UTSW	3	59,752,248 (GRCm38)	missense	possibly damaging	0.80
R1127:Gm5538	UTSW	3	59,751,893 (GRCm38)	missense	probably benign	0.00
R1916:Gm5538	UTSW	3	59,745,503 (GRCm38)	missense	possibly damaging	0.48
R3008:Gm5538	UTSW	3	59,745,509 (GRCm38)	missense	possibly damaging	0.93
R3921:Gm5538	UTSW	3	59,752,077 (GRCm38)	missense	probably damaging	0.98
R4368:Gm5538	UTSW	3	59,751,966 (GRCm38)	missense	probably damaging	1.00
R5240:Gm5538	UTSW	3	59,752,028 (GRCm38)	missense	probably damaging	0.99
R5268:Gm5538	UTSW	3	59,752,023 (GRCm38)	missense	probably damaging	0.99
R5511:Gm5538	UTSW	3	59,747,264 (GRCm38)	missense	probably damaging	1.00
R5564:Gm5538	UTSW	3	59,752,092 (GRCm38)	missense	probably benign
R5812:Gm5538	UTSW	3	59,747,272 (GRCm38)	missense	probably damaging	1.00
R5981:Gm5538	UTSW	3	59,751,878 (GRCm38)	missense	probably benign
R6049:Gm5538	UTSW	3	59,752,149 (GRCm38)	missense	probably damaging	1.00
R6195:Gm5538	UTSW	3	59,752,202 (GRCm38)	missense	probably damaging	0.98
R6353:Gm5538	UTSW	3	59,752,108 (GRCm38)	missense	probably damaging	1.00
R6449:Gm5538	UTSW	3	59,745,551 (GRCm38)	missense	probably damaging	1.00
R6845:Gm5538	UTSW	3	59,752,118 (GRCm38)	missense	probably damaging	1.00
R7382:Gm5538	UTSW	3	59,743,616 (GRCm38)	missense	probably benign	0.18
R7585:Gm5538	UTSW	3	59,743,722 (GRCm38)	missense	possibly damaging	0.94
R7827:Gm5538	UTSW	3	59,743,691 (GRCm38)	missense	probably damaging	0.99
R7844:Gm5538	UTSW	3	59,729,897 (GRCm38)	missense	probably benign	0.32
R8308:Gm5538	UTSW	3	59,752,149 (GRCm38)	missense	probably damaging	1.00
R8830:Gm5538	UTSW	3	59,747,323 (GRCm38)	missense	probably benign	0.03
R9447:Gm5538	UTSW	3	59,743,630 (GRCm38)	missense	probably damaging	0.96
R9557:Gm5538	UTSW	3	59,751,739 (GRCm38)	missense	possibly damaging	0.89
Z1176:Gm5538	UTSW	3	59,747,194 (GRCm38)	missense	probably benign	0.08

Posted On

2015-04-16