Incidental Mutation 'IGL02335:Zfp936'
ID 289707
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp936
Ensembl Gene ENSMUSG00000064194
Gene Name zinc finger protein 936
Synonyms EG435970, Gm9272, I1C0022H11Rik
Accession Numbers
Essential gene? Possibly essential (E-score: 0.670) question?
Stock # IGL02335
Quality Score
Status
Chromosome 7
Chromosomal Location 42763653-42841533 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 42836691 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 34 (L34Q)
Ref Sequence ENSEMBL: ENSMUSP00000144191 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072829] [ENSMUST00000200973] [ENSMUST00000202535] [ENSMUST00000205912]
AlphaFold Q3ULA8
Predicted Effect probably damaging
Transcript: ENSMUST00000072829
AA Change: L33Q

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000072608
Gene: ENSMUSG00000064194
AA Change: L33Q

DomainStartEndE-ValueType
KRAB 3 65 5.32e-19 SMART
ZnF_C2H2 148 170 5.9e-3 SMART
ZnF_C2H2 176 198 5.9e-3 SMART
ZnF_C2H2 204 226 1.4e-4 SMART
ZnF_C2H2 232 254 1.2e-3 SMART
ZnF_C2H2 260 282 7.37e-4 SMART
ZnF_C2H2 288 310 2.27e-4 SMART
ZnF_C2H2 316 338 2.09e-3 SMART
ZnF_C2H2 344 366 1.45e-2 SMART
ZnF_C2H2 372 394 1.82e-3 SMART
ZnF_C2H2 400 422 2.53e-2 SMART
ZnF_C2H2 428 450 4.54e-4 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000200973
AA Change: L34Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000144191
Gene: ENSMUSG00000064194
AA Change: L34Q

DomainStartEndE-ValueType
KRAB 4 66 1.4e-21 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000202535
AA Change: L34Q

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000143800
Gene: ENSMUSG00000064194
AA Change: L34Q

DomainStartEndE-ValueType
KRAB 4 66 2.3e-21 SMART
ZnF_C2H2 149 171 2.6e-5 SMART
ZnF_C2H2 177 199 2.5e-5 SMART
ZnF_C2H2 205 227 5.9e-7 SMART
ZnF_C2H2 233 255 5.1e-6 SMART
ZnF_C2H2 261 283 3.1e-6 SMART
ZnF_C2H2 289 311 9.4e-7 SMART
ZnF_C2H2 317 339 8.7e-6 SMART
ZnF_C2H2 345 367 6.3e-5 SMART
ZnF_C2H2 373 395 7.7e-6 SMART
ZnF_C2H2 401 423 1.1e-4 SMART
ZnF_C2H2 429 451 2e-6 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000205912
AA Change: L34Q

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A4gnt C T 9: 99,502,266 (GRCm39) T142I probably benign Het
Aadacl2fm2 G A 3: 59,651,026 (GRCm39) M49I probably benign Het
Acaca A G 11: 84,105,084 (GRCm39) T147A possibly damaging Het
Agbl3 A G 6: 34,776,685 (GRCm39) D397G probably damaging Het
Ank1 C T 8: 23,625,654 (GRCm39) T1597M possibly damaging Het
Arl4d A G 11: 101,557,755 (GRCm39) T94A possibly damaging Het
Cd22 A G 7: 30,575,559 (GRCm39) I161T probably damaging Het
Clcn7 C T 17: 25,365,821 (GRCm39) L166F probably benign Het
Cnbd1 G T 4: 19,055,095 (GRCm39) N110K possibly damaging Het
Col14a1 A T 15: 55,327,165 (GRCm39) probably benign Het
Col6a6 C T 9: 105,661,300 (GRCm39) V270M probably damaging Het
Cox8b C A 7: 140,478,990 (GRCm39) G42W probably damaging Het
Csn1s1 A T 5: 87,828,704 (GRCm39) D275V probably benign Het
Cubn T A 2: 13,432,645 (GRCm39) probably null Het
Dctn2 T C 10: 127,111,690 (GRCm39) probably benign Het
Dnm1l A G 16: 16,160,604 (GRCm39) probably benign Het
Dpp4 T C 2: 62,164,988 (GRCm39) E687G probably benign Het
Fbxw20 T C 9: 109,052,377 (GRCm39) K249E possibly damaging Het
Fhl2 C T 1: 43,167,550 (GRCm39) W181* probably null Het
G2e3 T A 12: 51,415,941 (GRCm39) M559K probably benign Het
Gdap1l1 A T 2: 163,289,515 (GRCm39) Y160F possibly damaging Het
Gm1110 T C 9: 26,793,059 (GRCm39) I572M probably benign Het
Gpatch2l T A 12: 86,303,711 (GRCm39) probably benign Het
Kcnq4 A G 4: 120,573,051 (GRCm39) L250P probably damaging Het
Lamc2 A T 1: 153,041,962 (GRCm39) N57K probably benign Het
Lingo1 A G 9: 56,527,365 (GRCm39) L408P probably damaging Het
Mmrn1 A T 6: 60,954,131 (GRCm39) N804I possibly damaging Het
Mroh7 A G 4: 106,564,979 (GRCm39) L545S probably damaging Het
Nup188 T A 2: 30,213,648 (GRCm39) probably null Het
Or10q1 A G 19: 13,727,298 (GRCm39) D276G probably benign Het
Or11a4 A G 17: 37,536,217 (GRCm39) N67S probably damaging Het
Or5b94 T C 19: 12,651,602 (GRCm39) I11T probably damaging Het
Pls1 A T 9: 95,666,236 (GRCm39) N138K probably benign Het
Prkch C A 12: 73,749,286 (GRCm39) N345K probably benign Het
Reps1 T C 10: 17,931,865 (GRCm39) probably null Het
Rrp7a T C 15: 83,006,892 (GRCm39) E15G probably benign Het
Scart2 A T 7: 139,876,453 (GRCm39) N526Y probably damaging Het
Scn1a T A 2: 66,108,005 (GRCm39) T1557S possibly damaging Het
Smtn T C 11: 3,476,215 (GRCm39) E602G probably damaging Het
Syvn1 T C 19: 6,100,123 (GRCm39) probably null Het
Tbxas1 A G 6: 39,000,014 (GRCm39) D267G probably damaging Het
Topbp1 A G 9: 103,205,722 (GRCm39) N787D probably damaging Het
Vmn2r22 T G 6: 123,615,051 (GRCm39) S180R probably damaging Het
Zfp345 T A 2: 150,316,463 (GRCm39) E48D possibly damaging Het
Zfp608 G A 18: 55,030,509 (GRCm39) Q1144* probably null Het
Other mutations in Zfp936
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02231:Zfp936 APN 7 42,836,909 (GRCm39) splice site probably null
IGL02245:Zfp936 APN 7 42,836,722 (GRCm39) critical splice donor site probably null
FR4340:Zfp936 UTSW 7 42,838,913 (GRCm39) missense possibly damaging 0.63
R0437:Zfp936 UTSW 7 42,838,734 (GRCm39) missense probably benign 0.00
R3899:Zfp936 UTSW 7 42,839,158 (GRCm39) missense possibly damaging 0.93
R4120:Zfp936 UTSW 7 42,839,630 (GRCm39) missense probably benign 0.10
R4406:Zfp936 UTSW 7 42,839,748 (GRCm39) missense possibly damaging 0.82
R4959:Zfp936 UTSW 7 42,839,034 (GRCm39) missense probably damaging 1.00
R5023:Zfp936 UTSW 7 42,836,681 (GRCm39) missense probably damaging 1.00
R5163:Zfp936 UTSW 7 42,839,664 (GRCm39) missense probably damaging 1.00
R5182:Zfp936 UTSW 7 42,839,331 (GRCm39) missense probably damaging 1.00
R5292:Zfp936 UTSW 7 42,838,759 (GRCm39) nonsense probably null
R5668:Zfp936 UTSW 7 42,839,858 (GRCm39) missense possibly damaging 0.93
R6057:Zfp936 UTSW 7 42,839,787 (GRCm39) missense probably benign 0.00
R6901:Zfp936 UTSW 7 42,839,467 (GRCm39) missense probably damaging 1.00
R7139:Zfp936 UTSW 7 42,839,715 (GRCm39) missense possibly damaging 0.54
R7258:Zfp936 UTSW 7 42,839,803 (GRCm39) missense probably damaging 1.00
R7440:Zfp936 UTSW 7 42,836,685 (GRCm39) missense probably damaging 1.00
R7537:Zfp936 UTSW 7 42,839,239 (GRCm39) nonsense probably null
R7561:Zfp936 UTSW 7 42,839,339 (GRCm39) missense probably damaging 0.98
R7662:Zfp936 UTSW 7 42,839,336 (GRCm39) nonsense probably null
R7775:Zfp936 UTSW 7 42,839,720 (GRCm39) missense possibly damaging 0.70
R7778:Zfp936 UTSW 7 42,839,720 (GRCm39) missense possibly damaging 0.70
R8016:Zfp936 UTSW 7 42,838,848 (GRCm39) missense possibly damaging 0.61
R8121:Zfp936 UTSW 7 42,839,547 (GRCm39) missense possibly damaging 0.55
R9012:Zfp936 UTSW 7 42,839,416 (GRCm39) nonsense probably null
R9058:Zfp936 UTSW 7 42,839,196 (GRCm39) missense probably benign 0.32
R9188:Zfp936 UTSW 7 42,839,768 (GRCm39) missense probably benign 0.00
R9236:Zfp936 UTSW 7 42,836,922 (GRCm39) missense probably benign 0.00
R9596:Zfp936 UTSW 7 42,839,834 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16