Incidental Mutation 'IGL02350:Or10am5'
ID 289739
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10am5
Ensembl Gene ENSMUSG00000048067
Gene Name olfactory receptor family 10 subfamily AM member 5
Synonyms Olfr1349, MOR232-8, GA_x6K02T2QGBW-3245761-3244808
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # IGL02350
Quality Score
Status
Chromosome 7
Chromosomal Location 6517198-6523354 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 6518225 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 68 (M68L)
Ref Sequence ENSEMBL: ENSMUSP00000146944 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051982] [ENSMUST00000207043] [ENSMUST00000207075] [ENSMUST00000207820] [ENSMUST00000213504] [ENSMUST00000216447] [ENSMUST00000213656]
AlphaFold Q7TQV1
Predicted Effect possibly damaging
Transcript: ENSMUST00000051982
AA Change: M68L

PolyPhen 2 Score 0.944 (Sensitivity: 0.80; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000056639
Gene: ENSMUSG00000048067
AA Change: M68L

DomainStartEndE-ValueType
Pfam:7tm_4 40 317 1.9e-47 PFAM
Pfam:7tm_1 50 299 3.3e-18 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000122705
Predicted Effect probably damaging
Transcript: ENSMUST00000207043
AA Change: M68L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000207075
AA Change: M68L

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect possibly damaging
Transcript: ENSMUST00000207820
AA Change: M68L

PolyPhen 2 Score 0.944 (Sensitivity: 0.80; Specificity: 0.95)
Predicted Effect possibly damaging
Transcript: ENSMUST00000213504
AA Change: M68L

PolyPhen 2 Score 0.944 (Sensitivity: 0.80; Specificity: 0.95)
Predicted Effect possibly damaging
Transcript: ENSMUST00000216447
AA Change: M68L

PolyPhen 2 Score 0.944 (Sensitivity: 0.80; Specificity: 0.95)
Predicted Effect possibly damaging
Transcript: ENSMUST00000213656
AA Change: M68L

PolyPhen 2 Score 0.944 (Sensitivity: 0.80; Specificity: 0.95)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd8 A G 8: 71,914,121 (GRCm39) V169A probably benign Het
Adamts16 T A 13: 70,886,704 (GRCm39) T1029S probably benign Het
Adgrv1 C A 13: 81,418,974 (GRCm39) C6007F probably benign Het
Ak8 A T 2: 28,590,225 (GRCm39) H8L probably benign Het
Apol7b A G 15: 77,307,832 (GRCm39) V221A probably benign Het
BC005624 G A 2: 30,863,779 (GRCm39) P235S probably benign Het
Cd96 A G 16: 45,890,139 (GRCm39) probably benign Het
Celf1 A T 2: 90,828,933 (GRCm39) K27I probably damaging Het
Cfap65 A T 1: 74,967,507 (GRCm39) C190* probably null Het
Cib2 A T 9: 54,457,170 (GRCm39) H31Q probably damaging Het
Cyp3a59 T C 5: 146,016,152 (GRCm39) L3P probably damaging Het
Dnajc13 T C 9: 104,039,558 (GRCm39) M2104V possibly damaging Het
Dph3b-ps A G 13: 106,683,453 (GRCm39) noncoding transcript Het
Emb A G 13: 117,386,007 (GRCm39) probably benign Het
Fbn2 G T 18: 58,237,067 (GRCm39) N645K possibly damaging Het
Fes T C 7: 80,033,578 (GRCm39) probably null Het
Flnc A T 6: 29,438,492 (GRCm39) K129* probably null Het
Gckr C A 5: 31,465,134 (GRCm39) H368N possibly damaging Het
Gm5145 A T 17: 20,790,702 (GRCm39) I27F probably damaging Het
Hecw1 A G 13: 14,422,923 (GRCm39) probably null Het
Hivep3 T G 4: 119,980,222 (GRCm39) C1753W probably damaging Het
Hook2 C T 8: 85,721,614 (GRCm39) Q291* probably null Het
Jakmip2 T C 18: 43,680,192 (GRCm39) T722A possibly damaging Het
Kcnt2 A G 1: 140,279,007 (GRCm39) I53V probably benign Het
Lipo2 A G 19: 33,708,348 (GRCm39) L222P possibly damaging Het
Mrc2 A G 11: 105,216,547 (GRCm39) D112G probably damaging Het
Mroh2b A G 15: 4,941,482 (GRCm39) N338S probably benign Het
Mrpl23 T A 7: 142,089,802 (GRCm39) probably benign Het
Myo18a A G 11: 77,741,073 (GRCm39) N1442S probably benign Het
Ngdn T A 14: 55,259,393 (GRCm39) V179E probably damaging Het
Nxn A G 11: 76,165,480 (GRCm39) probably benign Het
Or2b7 A G 13: 21,739,772 (GRCm39) L140P probably damaging Het
Osmr A T 15: 6,858,144 (GRCm39) N441K probably benign Het
Plcb3 A C 19: 6,935,546 (GRCm39) L789R probably damaging Het
Plek C T 11: 16,931,846 (GRCm39) R335H probably damaging Het
Pmp22 G T 11: 63,049,134 (GRCm39) V126F probably benign Het
Prom1 A G 5: 44,186,946 (GRCm39) probably benign Het
Prss1 C A 6: 41,440,139 (GRCm39) Q159K probably damaging Het
Psd3 G T 8: 68,416,521 (GRCm39) H459N probably benign Het
Rusc2 T G 4: 43,425,351 (GRCm39) V1152G possibly damaging Het
Slc16a4 A G 3: 107,210,415 (GRCm39) I362V probably benign Het
Slc22a22 A G 15: 57,110,844 (GRCm39) V461A probably benign Het
Slc35e4 C T 11: 3,862,640 (GRCm39) R183Q probably benign Het
Spen T C 4: 141,204,890 (GRCm39) T1246A unknown Het
Syt16 T C 12: 74,313,616 (GRCm39) V514A probably benign Het
Tdpoz2 A G 3: 93,559,735 (GRCm39) V79A possibly damaging Het
Ttn A G 2: 76,539,963 (GRCm39) V34341A probably benign Het
Vxn T C 1: 9,683,544 (GRCm39) I44T possibly damaging Het
Wwox T C 8: 115,438,882 (GRCm39) V316A possibly damaging Het
Other mutations in Or10am5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00917:Or10am5 APN 7 6,517,577 (GRCm39) missense probably damaging 1.00
IGL02357:Or10am5 APN 7 6,518,225 (GRCm39) missense probably damaging 1.00
IGL02955:Or10am5 APN 7 6,517,682 (GRCm39) missense probably damaging 1.00
R0593:Or10am5 UTSW 7 6,517,808 (GRCm39) missense probably benign 0.00
R2311:Or10am5 UTSW 7 6,517,741 (GRCm39) missense probably benign
R2396:Or10am5 UTSW 7 6,517,784 (GRCm39) missense probably damaging 0.98
R3699:Or10am5 UTSW 7 6,517,993 (GRCm39) missense probably damaging 0.99
R4095:Or10am5 UTSW 7 6,518,252 (GRCm39) missense possibly damaging 0.94
R5009:Or10am5 UTSW 7 6,517,546 (GRCm39) missense probably damaging 0.99
R6818:Or10am5 UTSW 7 6,517,550 (GRCm39) missense probably damaging 0.99
R7248:Or10am5 UTSW 7 6,517,520 (GRCm39) missense probably damaging 1.00
R7697:Or10am5 UTSW 7 6,517,645 (GRCm39) missense probably damaging 1.00
R7848:Or10am5 UTSW 7 6,517,861 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16