Incidental Mutation 'IGL02278:Zfp850'
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List
[record 1 of 9] next >> last >|
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| ID | 289768 |
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| Institutional Source |
Australian Phenomics Network
(link to record)
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| Gene Symbol |
Zfp850
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| Ensembl Gene |
ENSMUSG00000096916 |
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| Gene Name | zinc finger protein 850 |
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| Synonyms | C130069I09Rik, Gm4636 |
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| Accession Numbers | |
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| Is this an essential gene? |
Probably non essential (E-score: 0.066)
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| Stock # | IGL02278
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| Quality Score | |
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| Status |
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| Chromosome | 7 |
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| Chromosomal Location | 27984854-28014115 bp(-) (GRCm38) |
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| Type of Mutation | missense |
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| DNA Base Change (assembly) |
T to A
at 28008397 bp
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| Zygosity | Heterozygous |
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| Amino Acid Change |
Glutamine to Leucine
at position 7
(Q7L)
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| Ref Sequence |
ENSEMBL: ENSMUSP00000141063
(fasta)
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| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000180024]
[ENSMUST00000180502]
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| Predicted Effect |
probably damaging
Transcript: ENSMUST00000180024
AA Change: Q7L
PolyPhen 2
Score 0.960 (Sensitivity: 0.78; Specificity: 0.95)
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| SMART Domains |
Protein: ENSMUSP00000137192
Gene: ENSMUSG00000096916
AA Change: Q7L
| Domain | Start | End | E-Value | Type |
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|
KRAB
|
14 |
75 |
1.56e-34 |
SMART |
|
ZnF_C2H2
|
172 |
194 |
7.18e1 |
SMART |
|
ZnF_C2H2
|
200 |
222 |
3.63e-3 |
SMART |
|
ZnF_C2H2
|
228 |
250 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
256 |
278 |
7.49e-5 |
SMART |
|
ZnF_C2H2
|
313 |
335 |
1.01e-1 |
SMART |
|
ZnF_C2H2
|
341 |
363 |
4.4e-2 |
SMART |
|
ZnF_C2H2
|
369 |
391 |
7.37e-4 |
SMART |
|
ZnF_C2H2
|
397 |
419 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
425 |
447 |
1.92e-2 |
SMART |
|
ZnF_C2H2
|
453 |
475 |
2.99e-4 |
SMART |
|
ZnF_C2H2
|
481 |
503 |
7.78e-3 |
SMART |
|
ZnF_C2H2
|
509 |
531 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
537 |
559 |
1.92e-2 |
SMART |
|
ZnF_C2H2
|
565 |
587 |
2.99e-4 |
SMART |
|
ZnF_C2H2
|
593 |
615 |
1.79e-2 |
SMART |
|
ZnF_C2H2
|
621 |
643 |
7.37e-4 |
SMART |
|
ZnF_C2H2
|
649 |
671 |
4.4e-2 |
SMART |
|
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| Predicted Effect |
probably damaging
Transcript: ENSMUST00000180502
AA Change: Q7L
PolyPhen 2
Score 0.960 (Sensitivity: 0.78; Specificity: 0.95)
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| SMART Domains |
Protein: ENSMUSP00000141063
Gene: ENSMUSG00000096916
AA Change: Q7L
| Domain | Start | End | E-Value | Type |
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|
KRAB
|
14 |
75 |
6.5e-37 |
SMART |
|
ZnF_C2H2
|
172 |
194 |
3e-1 |
SMART |
|
ZnF_C2H2
|
200 |
222 |
1.5e-5 |
SMART |
|
ZnF_C2H2
|
228 |
250 |
3.8e-5 |
SMART |
|
ZnF_C2H2
|
256 |
274 |
2.5e-1 |
SMART |
|
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| Coding Region Coverage |
|
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| Validation Efficiency |
|
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| Allele List at MGI | |
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| Other mutations in this stock |
Total: 8 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
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| Bbs4 |
T |
A |
9: 59,341,168 |
Q84L |
possibly damaging |
Het |
| Cemip |
A |
T |
7: 83,937,438 |
W1303R |
probably damaging |
Het |
| Edrf1 |
T |
C |
7: 133,657,000 |
S702P |
probably benign |
Het |
| Muc4 |
C |
A |
16: 32,754,529 |
H1468N |
probably benign |
Het |
| Nav1 |
G |
A |
1: 135,463,714 |
|
probably benign |
Het |
| Pramel5 |
A |
G |
4: 144,271,551 |
L374P |
probably damaging |
Het |
| Slc2a2 |
T |
C |
3: 28,717,455 |
I178T |
probably damaging |
Het |
| Tsnaxip1 |
A |
G |
8: 105,827,781 |
|
probably benign |
Het |
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| Other mutations in Zfp850 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
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|
R0610:Zfp850
|
UTSW |
7 |
27989394 |
missense |
probably damaging |
0.99 |
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R0690:Zfp850
|
UTSW |
7 |
27985217 |
missense |
possibly damaging |
0.67 |
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R0711:Zfp850
|
UTSW |
7 |
27990273 |
missense |
probably benign |
0.00 |
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R1310:Zfp850
|
UTSW |
7 |
27989459 |
missense |
probably benign |
0.40 |
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R1594:Zfp850
|
UTSW |
7 |
27989391 |
missense |
probably benign |
0.00 |
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R1771:Zfp850
|
UTSW |
7 |
27985275 |
nonsense |
probably null |
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R2189:Zfp850
|
UTSW |
7 |
27989055 |
missense |
probably benign |
0.02 |
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R2192:Zfp850
|
UTSW |
7 |
27985195 |
missense |
probably damaging |
1.00 |
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R2417:Zfp850
|
UTSW |
7 |
27989183 |
missense |
possibly damaging |
0.54 |
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R4321:Zfp850
|
UTSW |
7 |
27989400 |
missense |
probably damaging |
0.99 |
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R4770:Zfp850
|
UTSW |
7 |
27984986 |
splice site |
probably null |
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R4970:Zfp850
|
UTSW |
7 |
27990233 |
nonsense |
probably null |
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R5112:Zfp850
|
UTSW |
7 |
27990233 |
nonsense |
probably null |
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R5166:Zfp850
|
UTSW |
7 |
27990356 |
nonsense |
probably null |
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R5303:Zfp850
|
UTSW |
7 |
28008413 |
missense |
probably damaging |
1.00 |
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R5315:Zfp850
|
UTSW |
7 |
27990318 |
missense |
probably benign |
0.02 |
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R5496:Zfp850
|
UTSW |
7 |
28007346 |
missense |
probably damaging |
0.98 |
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R5547:Zfp850
|
UTSW |
7 |
27989419 |
missense |
probably damaging |
1.00 |
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R5677:Zfp850
|
UTSW |
7 |
27989088 |
missense |
probably damaging |
1.00 |
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R5927:Zfp850
|
UTSW |
7 |
27990195 |
missense |
probably benign |
0.17 |
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R6654:Zfp850
|
UTSW |
7 |
27985215 |
nonsense |
probably null |
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R6950:Zfp850
|
UTSW |
7 |
27990514 |
missense |
possibly damaging |
0.86 |
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R6987:Zfp850
|
UTSW |
7 |
27990001 |
missense |
probably damaging |
1.00 |
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R6990:Zfp850
|
UTSW |
7 |
27990376 |
missense |
probably benign |
0.09 |
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R7640:Zfp850
|
UTSW |
7 |
27989209 |
missense |
probably benign |
0.05 |
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R7856:Zfp850
|
UTSW |
7 |
27990474 |
missense |
probably benign |
0.02 |
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| Posted On | 2015-04-16 |
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