Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02282:Prss37'

289857

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Prss37

Ensembl Gene

ENSMUSG00000029909

Gene Name

protease, serine 37

Synonyms

1700016G05Rik

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02282

Quality Score

Status

Chromosome

Chromosomal Location

40514824-40519508 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 40515383 bp

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 178 (V178A)

Ref Sequence

ENSEMBL: ENSMUSP00000031967 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000031967]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000031967
AA Change: V178A

PolyPhen 2 Score 0.814 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000031967
Gene: ENSMUSG00000029909
AA Change: V178A

Domain	Start	End	E-Value	Type
Tryp_SPc	15	228	2.31e-15	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000148195

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit male infertility associated with impaired zona binding and migration from the uterus into the oviduct. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2610507B11Rik	C	T	11: 78,284,228	P1730S	probably benign	Het
Ahnak	A	G	19: 9,005,987	D1545G	probably damaging	Het
AI481877	A	C	4: 59,111,114	Y53D	unknown	Het
Baiap3	A	C	17: 25,249,377	D234E	probably benign	Het
Cand1	T	A	10: 119,210,709	T959S	probably benign	Het
Ctdspl2	A	G	2: 121,977,478		probably benign	Het
Cyp2a4	A	C	7: 26,309,047	M205L	probably benign	Het
Dlx5	G	A	6: 6,881,762	A42V	probably damaging	Het
Dnah7a	A	G	1: 53,643,510	I267T	possibly damaging	Het
Dnajb6	A	G	5: 29,752,418	D66G	probably damaging	Het
Fgf8	T	C	19: 45,737,090	H201R	possibly damaging	Het
Gpc1	A	G	1: 92,857,967	K460E	probably damaging	Het
Gzme	A	T	14: 56,118,369	L162Q	probably damaging	Het
Ik	G	A	18: 36,745,644	G17D	probably damaging	Het
Il4	G	A	11: 53,618,174	T59M	probably damaging	Het
Kcnh3	G	T	15: 99,228,043		probably null	Het
Mill1	G	T	7: 18,263,204		probably null	Het
Npbwr1	A	T	1: 5,916,965	M110K	possibly damaging	Het
Olfr1490	T	A	19: 13,655,258	D276E	probably damaging	Het
Olfr849	A	G	9: 19,441,618	Y235C	probably benign	Het
Olfr881	A	T	9: 37,993,022	I177F	probably damaging	Het
Opalin	A	T	19: 41,066,504	S84T	probably benign	Het
Pcdhb11	T	C	18: 37,423,828	L737P	probably damaging	Het
Phip	G	A	9: 82,913,690	S626L	probably benign	Het
Ppl	T	C	16: 5,101,458	D435G	probably damaging	Het
Ptpn7	A	G	1: 135,134,834	I104V	probably damaging	Het
Ptprn	A	G	1: 75,253,156	Y700H	probably damaging	Het
Rab11fip5	T	A	6: 85,337,552	T555S	probably damaging	Het
Rfwd3	A	T	8: 111,293,982		probably benign	Het
Robo1	G	A	16: 72,742,138	R41H	probably damaging	Het
Rps3	A	G	7: 99,479,272		probably null	Het
Ruvbl2	G	A	7: 45,425,165	T183I	probably benign	Het
Sema4c	A	T	1: 36,550,203		probably null	Het
Taar8b	T	A	10: 24,091,555	K247I	possibly damaging	Het
Tacr3	A	T	3: 134,861,073	I236F	probably benign	Het
Ttc21b	A	G	2: 66,191,737	I1168T	probably damaging	Het
Ttc9b	A	T	7: 27,655,911	D202V	probably damaging	Het
Vmn2r26	T	G	6: 124,061,625	C720G	probably damaging	Het
Vmn2r37	A	G	7: 9,206,762	S584P	probably benign	Het
Wnk2	T	A	13: 49,068,125	D1208V	probably damaging	Het
Zfp988	T	A	4: 147,331,668	C186*	probably null	Het
Zp3	A	G	5: 135,984,351	N179S	possibly damaging	Het

Other mutations in Prss37

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03110:Prss37	APN	6	40519050	missense	probably benign	0.00
R0201:Prss37	UTSW	6	40516349	missense	probably damaging	1.00
R0350:Prss37	UTSW	6	40514959	missense	probably damaging	0.99
R2118:Prss37	UTSW	6	40515360	nonsense	probably null
R2120:Prss37	UTSW	6	40515360	nonsense	probably null
R2124:Prss37	UTSW	6	40515360	nonsense	probably null
R2504:Prss37	UTSW	6	40517826	splice site	probably null
R4711:Prss37	UTSW	6	40515447	missense	probably benign	0.21
R4938:Prss37	UTSW	6	40514983	missense	possibly damaging	0.81
R4983:Prss37	UTSW	6	40516136	missense	probably benign	0.01
R6652:Prss37	UTSW	6	40519156	start gained	probably benign
X0063:Prss37	UTSW	6	40516215	missense	possibly damaging	0.65

Posted On

2015-04-16