Incidental Mutation 'IGL02282:Gzme'
ID289883
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gzme
Ensembl Gene ENSMUSG00000022156
Gene Namegranzyme E
SynonymsCtla6, MCSP-2, Ctla-6, CCP3
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.085) question?
Stock #IGL02282
Quality Score
Status
Chromosome14
Chromosomal Location56117626-56120625 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 56118369 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Glutamine at position 162 (L162Q)
Ref Sequence ENSEMBL: ENSMUSP00000086978 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089549]
Predicted Effect probably damaging
Transcript: ENSMUST00000089549
AA Change: L162Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000086978
Gene: ENSMUSG00000022156
AA Change: L162Q

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Tryp_SPc 20 241 9.48e-76 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610507B11Rik C T 11: 78,284,228 P1730S probably benign Het
Ahnak A G 19: 9,005,987 D1545G probably damaging Het
AI481877 A C 4: 59,111,114 Y53D unknown Het
Baiap3 A C 17: 25,249,377 D234E probably benign Het
Cand1 T A 10: 119,210,709 T959S probably benign Het
Ctdspl2 A G 2: 121,977,478 probably benign Het
Cyp2a4 A C 7: 26,309,047 M205L probably benign Het
Dlx5 G A 6: 6,881,762 A42V probably damaging Het
Dnah7a A G 1: 53,643,510 I267T possibly damaging Het
Dnajb6 A G 5: 29,752,418 D66G probably damaging Het
Fgf8 T C 19: 45,737,090 H201R possibly damaging Het
Gpc1 A G 1: 92,857,967 K460E probably damaging Het
Ik G A 18: 36,745,644 G17D probably damaging Het
Il4 G A 11: 53,618,174 T59M probably damaging Het
Kcnh3 G T 15: 99,228,043 probably null Het
Mill1 G T 7: 18,263,204 probably null Het
Npbwr1 A T 1: 5,916,965 M110K possibly damaging Het
Olfr1490 T A 19: 13,655,258 D276E probably damaging Het
Olfr849 A G 9: 19,441,618 Y235C probably benign Het
Olfr881 A T 9: 37,993,022 I177F probably damaging Het
Opalin A T 19: 41,066,504 S84T probably benign Het
Pcdhb11 T C 18: 37,423,828 L737P probably damaging Het
Phip G A 9: 82,913,690 S626L probably benign Het
Ppl T C 16: 5,101,458 D435G probably damaging Het
Prss37 A G 6: 40,515,383 V178A possibly damaging Het
Ptpn7 A G 1: 135,134,834 I104V probably damaging Het
Ptprn A G 1: 75,253,156 Y700H probably damaging Het
Rab11fip5 T A 6: 85,337,552 T555S probably damaging Het
Rfwd3 A T 8: 111,293,982 probably benign Het
Robo1 G A 16: 72,742,138 R41H probably damaging Het
Rps3 A G 7: 99,479,272 probably null Het
Ruvbl2 G A 7: 45,425,165 T183I probably benign Het
Sema4c A T 1: 36,550,203 probably null Het
Taar8b T A 10: 24,091,555 K247I possibly damaging Het
Tacr3 A T 3: 134,861,073 I236F probably benign Het
Ttc21b A G 2: 66,191,737 I1168T probably damaging Het
Ttc9b A T 7: 27,655,911 D202V probably damaging Het
Vmn2r26 T G 6: 124,061,625 C720G probably damaging Het
Vmn2r37 A G 7: 9,206,762 S584P probably benign Het
Wnk2 T A 13: 49,068,125 D1208V probably damaging Het
Zfp988 T A 4: 147,331,668 C186* probably null Het
Zp3 A G 5: 135,984,351 N179S possibly damaging Het
Other mutations in Gzme
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01501:Gzme APN 14 56119401 missense probably damaging 1.00
IGL02488:Gzme APN 14 56118392 missense probably benign 0.00
IGL02995:Gzme APN 14 56118709 missense probably damaging 1.00
R0711:Gzme UTSW 14 56117739 missense probably damaging 0.97
R1483:Gzme UTSW 14 56118712 missense probably damaging 1.00
R1765:Gzme UTSW 14 56118414 missense probably damaging 1.00
R4827:Gzme UTSW 14 56119298 missense probably null 0.92
R5327:Gzme UTSW 14 56117767 missense probably benign 0.01
R5328:Gzme UTSW 14 56117767 missense probably benign 0.01
R5440:Gzme UTSW 14 56118453 missense possibly damaging 0.52
R6081:Gzme UTSW 14 56118307 missense possibly damaging 0.46
R6573:Gzme UTSW 14 56118826 missense probably benign 0.03
R7525:Gzme UTSW 14 56119333 missense probably benign 0.00
Posted On2015-04-16