Incidental Mutation 'IGL02283:Or7a41'
| ID |
289900 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Or7a41
|
| Ensembl Gene |
ENSMUSG00000060205 |
| Gene Name |
olfactory receptor family 7 subfamily A member 41 |
| Synonyms |
MOR139-3, Olfr57, GA_x6K02T2QGN0-2777431-2776472, IF12 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.076)
|
| Stock # |
IGL02283
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
10 |
| Chromosomal Location |
78870557-78871636 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 78871379 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 250
(S250P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000144814
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000082244]
[ENSMUST00000203906]
|
| AlphaFold |
Q8VGU7 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000082244
AA Change: S250P
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000080872
Gene: ENSMUSG00000060205
AA Change: S250P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_4
|
32 |
308 |
2.2e-49 |
PFAM |
|
Pfam:7tm_1
|
42 |
291 |
6e-28 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000203906
AA Change: S250P
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000144814
Gene: ENSMUSG00000060205
AA Change: S250P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
9 |
19 |
N/A |
INTRINSIC |
|
Pfam:7tm_4
|
32 |
308 |
2e-49 |
PFAM |
|
Pfam:7tm_1
|
42 |
291 |
1.9e-23 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 26 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aldh1l2 |
T |
C |
10: 83,331,759 (GRCm39) |
Y682C |
probably benign |
Het |
| Ank1 |
G |
A |
8: 23,609,450 (GRCm39) |
|
probably null |
Het |
| Arhgap1 |
A |
G |
2: 91,501,121 (GRCm39) |
N399S |
probably damaging |
Het |
| Atp8a2 |
A |
T |
14: 60,254,248 (GRCm39) |
I511N |
possibly damaging |
Het |
| Birc6 |
T |
A |
17: 74,906,935 (GRCm39) |
C1428S |
probably benign |
Het |
| Col18a1 |
T |
C |
10: 76,948,943 (GRCm39) |
T190A |
possibly damaging |
Het |
| Cpd |
A |
T |
11: 76,731,251 (GRCm39) |
D318E |
probably benign |
Het |
| Dync2h1 |
A |
T |
9: 7,125,912 (GRCm39) |
V1898E |
probably damaging |
Het |
| Gon4l |
T |
C |
3: 88,802,671 (GRCm39) |
M1095T |
probably damaging |
Het |
| Gypa |
G |
A |
8: 81,220,721 (GRCm39) |
|
probably benign |
Het |
| Irf9 |
G |
A |
14: 55,845,196 (GRCm39) |
R352H |
probably damaging |
Het |
| Macf1 |
T |
C |
4: 123,365,168 (GRCm39) |
T1633A |
probably benign |
Het |
| Mars2 |
T |
C |
1: 55,277,933 (GRCm39) |
V512A |
probably damaging |
Het |
| Myo9a |
A |
G |
9: 59,778,956 (GRCm39) |
N1571D |
probably benign |
Het |
| Myrfl |
T |
C |
10: 116,613,265 (GRCm39) |
D846G |
probably benign |
Het |
| Or2ak6 |
A |
T |
11: 58,593,102 (GRCm39) |
T192S |
probably damaging |
Het |
| Or2y1b |
A |
G |
11: 49,209,162 (GRCm39) |
D263G |
probably benign |
Het |
| Or4d11 |
A |
G |
19: 12,013,219 (GRCm39) |
S296P |
possibly damaging |
Het |
| Rprd2 |
A |
T |
3: 95,672,815 (GRCm39) |
S863T |
probably damaging |
Het |
| Sdf4 |
T |
A |
4: 156,093,293 (GRCm39) |
N208K |
probably benign |
Het |
| Sftpd |
A |
T |
14: 40,894,423 (GRCm39) |
V332D |
probably benign |
Het |
| Sh2b3 |
T |
C |
5: 121,956,718 (GRCm39) |
D321G |
probably benign |
Het |
| Slc45a2 |
T |
A |
15: 11,001,268 (GRCm39) |
N122K |
probably damaging |
Het |
| Slk |
T |
A |
19: 47,630,432 (GRCm39) |
F1170Y |
probably damaging |
Het |
| Spata7 |
A |
C |
12: 98,624,517 (GRCm39) |
T140P |
probably damaging |
Het |
| Vmn2r117 |
A |
G |
17: 23,694,356 (GRCm39) |
L497S |
probably damaging |
Het |
|
| Other mutations in Or7a41 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01347:Or7a41
|
APN |
10 |
78,871,445 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02230:Or7a41
|
APN |
10 |
78,870,876 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02878:Or7a41
|
APN |
10 |
78,871,392 (GRCm39) |
missense |
probably benign |
0.23 |
|
IGL02975:Or7a41
|
APN |
10 |
78,870,867 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL03259:Or7a41
|
APN |
10 |
78,871,234 (GRCm39) |
nonsense |
probably null |
|
|
R1366:Or7a41
|
UTSW |
10 |
78,870,876 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1438:Or7a41
|
UTSW |
10 |
78,871,122 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1528:Or7a41
|
UTSW |
10 |
78,871,398 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1601:Or7a41
|
UTSW |
10 |
78,871,338 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R2032:Or7a41
|
UTSW |
10 |
78,871,163 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R2112:Or7a41
|
UTSW |
10 |
78,871,248 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2382:Or7a41
|
UTSW |
10 |
78,870,968 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R2967:Or7a41
|
UTSW |
10 |
78,870,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3773:Or7a41
|
UTSW |
10 |
78,871,014 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R3940:Or7a41
|
UTSW |
10 |
78,871,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4405:Or7a41
|
UTSW |
10 |
78,871,244 (GRCm39) |
missense |
probably benign |
|
|
R5944:Or7a41
|
UTSW |
10 |
78,871,223 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6563:Or7a41
|
UTSW |
10 |
78,871,051 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R6614:Or7a41
|
UTSW |
10 |
78,870,925 (GRCm39) |
nonsense |
probably null |
|
|
R7181:Or7a41
|
UTSW |
10 |
78,871,287 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7639:Or7a41
|
UTSW |
10 |
78,871,206 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9427:Or7a41
|
UTSW |
10 |
78,871,395 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9508:Or7a41
|
UTSW |
10 |
78,870,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9652:Or7a41
|
UTSW |
10 |
78,871,230 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9681:Or7a41
|
UTSW |
10 |
78,871,577 (GRCm39) |
missense |
probably benign |
|
|
R9767:Or7a41
|
UTSW |
10 |
78,870,765 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
| Posted On |
2015-04-16 |
Incidental Mutation