Incidental Mutation 'IGL02285:Or52ad1'
| ID |
289965 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Or52ad1
|
| Ensembl Gene |
ENSMUSG00000045540 |
| Gene Name |
olfactory receptor family 52 subfamily AD member 1 |
| Synonyms |
Olfr600, MOR39-1, GA_x6K02T2PBJ9-6056235-6055291 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.078)
|
| Stock # |
IGL02285
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
102995189-102996133 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
G to A
at 102995245 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Stop codon
at position 297
(R297*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000148967
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000056222]
[ENSMUST00000215042]
|
| AlphaFold |
E9PUN7 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000056222
AA Change: R297*
|
| SMART Domains |
Protein: ENSMUSP00000053887
Gene: ENSMUSG00000045540
AA Change: R297*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_4
|
33 |
312 |
1.1e-97 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
37 |
226 |
1.2e-12 |
PFAM |
|
Pfam:7tm_1
|
43 |
305 |
7.2e-14 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000215042
AA Change: R297*
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 38 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ago3 |
A |
G |
4: 126,244,670 (GRCm39) |
V672A |
possibly damaging |
Het |
| Arhgef28 |
A |
T |
13: 98,187,536 (GRCm39) |
V253D |
possibly damaging |
Het |
| Atg3 |
G |
A |
16: 44,998,680 (GRCm39) |
|
probably benign |
Het |
| Camsap1 |
T |
C |
2: 25,819,814 (GRCm39) |
D1557G |
probably damaging |
Het |
| Cdh20 |
A |
G |
1: 110,065,921 (GRCm39) |
T732A |
probably damaging |
Het |
| Cert1 |
A |
G |
13: 96,752,990 (GRCm39) |
H348R |
probably benign |
Het |
| Cyp3a13 |
T |
A |
5: 137,908,229 (GRCm39) |
I207F |
probably benign |
Het |
| Dock1 |
T |
G |
7: 134,683,649 (GRCm39) |
|
probably null |
Het |
| Drc7 |
A |
T |
8: 95,797,861 (GRCm39) |
|
probably benign |
Het |
| Drosha |
C |
A |
15: 12,833,950 (GRCm39) |
P18H |
unknown |
Het |
| Fbxl5 |
A |
G |
5: 43,922,690 (GRCm39) |
S243P |
possibly damaging |
Het |
| Filip1 |
A |
G |
9: 79,727,408 (GRCm39) |
C404R |
probably damaging |
Het |
| Gm5745 |
G |
A |
9: 73,082,780 (GRCm39) |
|
noncoding transcript |
Het |
| Gm7808 |
T |
G |
9: 19,839,347 (GRCm39) |
|
probably benign |
Het |
| Gpi-ps |
C |
T |
8: 5,690,373 (GRCm39) |
|
noncoding transcript |
Het |
| Hcn3 |
T |
C |
3: 89,060,119 (GRCm39) |
D175G |
probably damaging |
Het |
| Igkv1-117 |
A |
T |
6: 68,098,519 (GRCm39) |
M23L |
probably benign |
Het |
| Kif26a |
A |
G |
12: 112,123,941 (GRCm39) |
D182G |
probably damaging |
Het |
| Lmbr1 |
A |
G |
5: 29,459,233 (GRCm39) |
|
probably benign |
Het |
| Lypd4 |
T |
A |
7: 24,564,865 (GRCm39) |
Q91L |
probably damaging |
Het |
| Ncoa5 |
C |
T |
2: 164,844,760 (GRCm39) |
A37T |
probably damaging |
Het |
| Or56b1 |
A |
G |
7: 104,284,932 (GRCm39) |
E17G |
probably benign |
Het |
| Or7g17 |
T |
A |
9: 18,768,286 (GRCm39) |
C122S |
possibly damaging |
Het |
| Ppp1r18 |
A |
G |
17: 36,178,148 (GRCm39) |
K8E |
probably damaging |
Het |
| Ppp3ca |
A |
G |
3: 136,634,387 (GRCm39) |
|
probably benign |
Het |
| Ptpn12 |
T |
A |
5: 21,260,711 (GRCm39) |
Q12L |
probably benign |
Het |
| Rpgrip1l |
A |
G |
8: 91,959,535 (GRCm39) |
F1122L |
possibly damaging |
Het |
| Rps15 |
G |
T |
10: 80,129,596 (GRCm39) |
M43I |
probably benign |
Het |
| Rrp15 |
T |
C |
1: 186,453,592 (GRCm39) |
|
probably benign |
Het |
| Sash1 |
A |
T |
10: 8,616,098 (GRCm39) |
M588K |
probably damaging |
Het |
| Slc12a7 |
A |
G |
13: 73,943,714 (GRCm39) |
|
probably benign |
Het |
| Slc25a13 |
A |
G |
6: 6,042,643 (GRCm39) |
V587A |
possibly damaging |
Het |
| Sugct |
T |
C |
13: 17,847,181 (GRCm39) |
D34G |
possibly damaging |
Het |
| Tdpoz2 |
T |
A |
3: 93,559,598 (GRCm39) |
I125F |
probably damaging |
Het |
| Trim52 |
T |
A |
14: 106,344,702 (GRCm39) |
L120Q |
probably damaging |
Het |
| Vmn1r85 |
T |
C |
7: 12,818,711 (GRCm39) |
I144M |
probably damaging |
Het |
| Vmn2r107 |
T |
C |
17: 20,595,823 (GRCm39) |
F792S |
probably damaging |
Het |
| Vsnl1 |
A |
G |
12: 11,436,878 (GRCm39) |
F34L |
probably damaging |
Het |
|
| Other mutations in Or52ad1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01525:Or52ad1
|
APN |
7 |
102,995,386 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL02239:Or52ad1
|
APN |
7 |
102,995,805 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02547:Or52ad1
|
APN |
7 |
102,995,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03149:Or52ad1
|
APN |
7 |
102,996,056 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0193:Or52ad1
|
UTSW |
7 |
102,995,411 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R0304:Or52ad1
|
UTSW |
7 |
102,995,918 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0454:Or52ad1
|
UTSW |
7 |
102,996,085 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0622:Or52ad1
|
UTSW |
7 |
102,996,064 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1988:Or52ad1
|
UTSW |
7 |
102,995,316 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1989:Or52ad1
|
UTSW |
7 |
102,995,316 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R2937:Or52ad1
|
UTSW |
7 |
102,995,272 (GRCm39) |
missense |
probably benign |
0.18 |
|
R4426:Or52ad1
|
UTSW |
7 |
102,995,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5362:Or52ad1
|
UTSW |
7 |
102,995,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5723:Or52ad1
|
UTSW |
7 |
102,995,826 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R6793:Or52ad1
|
UTSW |
7 |
102,995,473 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6863:Or52ad1
|
UTSW |
7 |
102,996,123 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6935:Or52ad1
|
UTSW |
7 |
102,996,002 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6983:Or52ad1
|
UTSW |
7 |
102,996,022 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7262:Or52ad1
|
UTSW |
7 |
102,995,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7313:Or52ad1
|
UTSW |
7 |
102,995,538 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7774:Or52ad1
|
UTSW |
7 |
102,995,737 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9246:Or52ad1
|
UTSW |
7 |
102,995,908 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9542:Or52ad1
|
UTSW |
7 |
102,995,569 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0018:Or52ad1
|
UTSW |
7 |
102,996,106 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Posted On |
2015-04-16 |
Incidental Mutation