Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02286:Xrra1'

289979

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Xrra1

Ensembl Gene

ENSMUSG00000035211

Gene Name

X-ray radiation resistance associated 1

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.089) question?

Stock #

IGL02286

Quality Score

Status

Chromosome

Chromosomal Location

99859116-99917822 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 99914227 bp

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 474 (I474F)

Ref Sequence

ENSEMBL: ENSMUSP00000035929 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000036155]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000036155
AA Change: I474F

PolyPhen 2 Score 0.622 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000035929
Gene: ENSMUSG00000035211
AA Change: I474F

Domain	Start	End	E-Value	Type
low complexity region	41	52	N/A	INTRINSIC
Blast:LRR	144	168	4e-6	BLAST
LRR	191	214	2.02e-1	SMART
LRR	232	253	1.67e2	SMART
LRR	257	278	6.41e1	SMART
LRR	371	398	4.09e1	SMART
low complexity region	748	756	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000208270

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000208449

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 15 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Dab1	A	G	4: 104,680,070	T187A	probably damaging	Het
Eno2	C	T	6: 124,766,580	R132H	probably damaging	Het
Fgb	T	G	3: 83,043,326	M374L	probably benign	Het
Fgf21	T	C	7: 45,615,137	D57G	possibly damaging	Het
Gcgr	A	G	11: 120,537,931	T354A	probably damaging	Het
Gm12790	T	C	4: 101,967,721	T117A	probably benign	Het
Myo18a	C	T	11: 77,777,985	Q224*	probably null	Het
N4bp2	A	G	5: 65,803,552	Y522C	probably damaging	Het
Nt5dc3	G	A	10: 86,820,780		probably benign	Het
Olfr1148	G	A	2: 87,833,248	A70T	probably damaging	Het
Ppp1r3b	C	T	8: 35,384,361	A118V	probably benign	Het
Slc37a2	C	T	9: 37,235,159	A351T	probably damaging	Het
Tlr11	T	C	14: 50,360,871	F105L	possibly damaging	Het
Vwa8	G	A	14: 78,947,273		probably null	Het
Zfp790	A	G	7: 29,829,735	K615R	possibly damaging	Het

Other mutations in Xrra1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01782:Xrra1	APN	7	99875194	missense	possibly damaging	0.76
IGL01938:Xrra1	APN	7	99879469	critical splice donor site	probably null
IGL02064:Xrra1	APN	7	99914204	missense	probably damaging	1.00
IGL02415:Xrra1	APN	7	99915943	missense	probably benign
R0332:Xrra1	UTSW	7	99876242	missense	probably damaging	1.00
R0465:Xrra1	UTSW	7	99879371	missense	probably benign	0.00
R0533:Xrra1	UTSW	7	99875145	splice site	probably null
R0601:Xrra1	UTSW	7	99910968	missense	possibly damaging	0.95
R1539:Xrra1	UTSW	7	99871357	missense	probably damaging	1.00
R1672:Xrra1	UTSW	7	99898440	missense	probably benign	0.00
R1687:Xrra1	UTSW	7	99876244	missense	probably damaging	1.00
R1962:Xrra1	UTSW	7	99911020	missense	probably damaging	1.00
R2504:Xrra1	UTSW	7	99897596	missense	probably damaging	1.00
R4765:Xrra1	UTSW	7	99906568	missense	probably benign	0.19
R4967:Xrra1	UTSW	7	99906523	missense	probably damaging	0.99
R5213:Xrra1	UTSW	7	99898483	missense	possibly damaging	0.47
R5663:Xrra1	UTSW	7	99886043	missense	probably damaging	1.00
R5986:Xrra1	UTSW	7	99876255	missense	probably benign	0.40
R6256:Xrra1	UTSW	7	99914464	missense	probably damaging	0.99
R6269:Xrra1	UTSW	7	99917472	missense	probably damaging	1.00
R7234:Xrra1	UTSW	7	99914249	missense	possibly damaging	0.49
R7316:Xrra1	UTSW	7	99876216	critical splice acceptor site	probably null
R7655:Xrra1	UTSW	7	99910982	missense	probably benign	0.10
R7656:Xrra1	UTSW	7	99910982	missense	probably benign	0.10
R8688:Xrra1	UTSW	7	99906545	missense	probably damaging	1.00
R8788:Xrra1	UTSW	7	99906554	missense	probably benign	0.02
X0017:Xrra1	UTSW	7	99916100	missense	probably damaging	1.00
X0021:Xrra1	UTSW	7	99898486	missense	possibly damaging	0.63

Posted On

2015-04-16