Incidental Mutation 'IGL02286:Xrra1'
ID289979
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Xrra1
Ensembl Gene ENSMUSG00000035211
Gene NameX-ray radiation resistance associated 1
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.089) question?
Stock #IGL02286
Quality Score
Status
Chromosome7
Chromosomal Location99859116-99917822 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 99914227 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 474 (I474F)
Ref Sequence ENSEMBL: ENSMUSP00000035929 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036155]
Predicted Effect possibly damaging
Transcript: ENSMUST00000036155
AA Change: I474F

PolyPhen 2 Score 0.622 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000035929
Gene: ENSMUSG00000035211
AA Change: I474F

DomainStartEndE-ValueType
low complexity region 41 52 N/A INTRINSIC
Blast:LRR 144 168 4e-6 BLAST
LRR 191 214 2.02e-1 SMART
LRR 232 253 1.67e2 SMART
LRR 257 278 6.41e1 SMART
LRR 371 398 4.09e1 SMART
low complexity region 748 756 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208270
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208449
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 15 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Dab1 A G 4: 104,680,070 T187A probably damaging Het
Eno2 C T 6: 124,766,580 R132H probably damaging Het
Fgb T G 3: 83,043,326 M374L probably benign Het
Fgf21 T C 7: 45,615,137 D57G possibly damaging Het
Gcgr A G 11: 120,537,931 T354A probably damaging Het
Gm12790 T C 4: 101,967,721 T117A probably benign Het
Myo18a C T 11: 77,777,985 Q224* probably null Het
N4bp2 A G 5: 65,803,552 Y522C probably damaging Het
Nt5dc3 G A 10: 86,820,780 probably benign Het
Olfr1148 G A 2: 87,833,248 A70T probably damaging Het
Ppp1r3b C T 8: 35,384,361 A118V probably benign Het
Slc37a2 C T 9: 37,235,159 A351T probably damaging Het
Tlr11 T C 14: 50,360,871 F105L possibly damaging Het
Vwa8 G A 14: 78,947,273 probably null Het
Zfp790 A G 7: 29,829,735 K615R possibly damaging Het
Other mutations in Xrra1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01782:Xrra1 APN 7 99875194 missense possibly damaging 0.76
IGL01938:Xrra1 APN 7 99879469 critical splice donor site probably null
IGL02064:Xrra1 APN 7 99914204 missense probably damaging 1.00
IGL02415:Xrra1 APN 7 99915943 missense probably benign
R0332:Xrra1 UTSW 7 99876242 missense probably damaging 1.00
R0465:Xrra1 UTSW 7 99879371 missense probably benign 0.00
R0533:Xrra1 UTSW 7 99875145 splice site probably null
R0601:Xrra1 UTSW 7 99910968 missense possibly damaging 0.95
R1539:Xrra1 UTSW 7 99871357 missense probably damaging 1.00
R1672:Xrra1 UTSW 7 99898440 missense probably benign 0.00
R1687:Xrra1 UTSW 7 99876244 missense probably damaging 1.00
R1962:Xrra1 UTSW 7 99911020 missense probably damaging 1.00
R2504:Xrra1 UTSW 7 99897596 missense probably damaging 1.00
R4765:Xrra1 UTSW 7 99906568 missense probably benign 0.19
R4967:Xrra1 UTSW 7 99906523 missense probably damaging 0.99
R5213:Xrra1 UTSW 7 99898483 missense possibly damaging 0.47
R5663:Xrra1 UTSW 7 99886043 missense probably damaging 1.00
R5986:Xrra1 UTSW 7 99876255 missense probably benign 0.40
R6256:Xrra1 UTSW 7 99914464 missense probably damaging 0.99
R6269:Xrra1 UTSW 7 99917472 missense probably damaging 1.00
R7234:Xrra1 UTSW 7 99914249 missense possibly damaging 0.49
R7316:Xrra1 UTSW 7 99876216 critical splice acceptor site probably null
R7655:Xrra1 UTSW 7 99910982 missense probably benign 0.10
R7656:Xrra1 UTSW 7 99910982 missense probably benign 0.10
R8688:Xrra1 UTSW 7 99906545 missense probably damaging 1.00
R8788:Xrra1 UTSW 7 99906554 missense probably benign 0.02
X0017:Xrra1 UTSW 7 99916100 missense probably damaging 1.00
X0021:Xrra1 UTSW 7 99898486 missense possibly damaging 0.63
Posted On2015-04-16