Incidental Mutation 'IGL02291:Olfr108'
ID 290310
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr108
Ensembl Gene ENSMUSG00000059687
Gene Name olfactory receptor 108
Synonyms MOR156-5, GA_x6K02T2PSCP-1893605-1894534
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.055) question?
Stock # IGL02291
Quality Score
Chromosome 17
Chromosomal Location 37445480-37446517 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to A at 37446285 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 255 (V255I)
Ref Sequence ENSEMBL: ENSMUSP00000151360 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078207] [ENSMUST00000207414] [ENSMUST00000218675]
AlphaFold Q8VFA1
Predicted Effect probably benign
Transcript: ENSMUST00000078207
AA Change: V244I

PolyPhen 2 Score 0.298 (Sensitivity: 0.91; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000077337
Gene: ENSMUSG00000059687
AA Change: V244I

Pfam:7TM_GPCR_Srv 33 315 8.8e-9 PFAM
Pfam:7tm_4 39 316 9.5e-54 PFAM
Pfam:7tm_1 49 298 1.8e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207414
AA Change: V255I
Predicted Effect possibly damaging
Transcript: ENSMUST00000218675
AA Change: V255I

PolyPhen 2 Score 0.617 (Sensitivity: 0.87; Specificity: 0.91)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AF366264 T A 8: 13,837,704 N129I probably benign Het
Arhgap10 T A 8: 77,382,715 probably benign Het
Cfap161 C T 7: 83,791,639 G135D probably benign Het
Cpne1 A G 2: 156,078,420 V179A probably damaging Het
Cpsf1 A T 15: 76,602,821 I219N probably damaging Het
Creb3l4 T G 3: 90,241,983 R139S probably benign Het
Fer1l4 T C 2: 156,019,538 K1929E probably damaging Het
Gm5431 A G 11: 48,888,964 L655P probably damaging Het
Igsf3 T G 3: 101,439,529 H613Q probably damaging Het
Kcnab1 T C 3: 65,357,082 Y251H possibly damaging Het
Kmt2d T C 15: 98,865,492 probably benign Het
Krt17 A T 11: 100,256,493 V404E probably benign Het
Lipo2 A G 19: 33,745,792 I199T possibly damaging Het
Mks1 T A 11: 87,859,667 probably benign Het
Nlrp1a A T 11: 71,122,589 probably null Het
Nup210 T C 6: 91,101,268 D100G probably damaging Het
Olfr1393 T A 11: 49,280,985 I279N probably damaging Het
Olfr532 A T 7: 140,419,287 L162Q probably damaging Het
Olfr871 T C 9: 20,212,802 I151T probably benign Het
Psmd5 A G 2: 34,857,799 V282A probably benign Het
Rasal3 A T 17: 32,393,737 probably benign Het
Rnf10 T C 5: 115,260,196 N93D probably damaging Het
Slc7a9 G A 7: 35,457,014 G294R probably damaging Het
Taf7 C T 18: 37,643,362 G51R possibly damaging Het
Tas2r126 G A 6: 42,435,287 M251I probably benign Het
Trim33 T C 3: 103,326,865 F473S probably damaging Het
Vmn1r127 A G 7: 21,319,074 L263P possibly damaging Het
Vmn1r234 G A 17: 21,228,931 V36I probably benign Het
Vmn2r84 T A 10: 130,390,748 H407L probably damaging Het
Other mutations in Olfr108
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01370:Olfr108 APN 17 37445714 missense probably benign 0.44
IGL01469:Olfr108 APN 17 37445535 missense probably benign 0.00
IGL02892:Olfr108 APN 17 37446034 missense probably damaging 1.00
IGL03390:Olfr108 APN 17 37446364 missense probably benign 0.02
R0115:Olfr108 UTSW 17 37445779 missense probably benign 0.00
R0395:Olfr108 UTSW 17 37445866 missense probably damaging 1.00
R0427:Olfr108 UTSW 17 37445702 missense probably damaging 0.99
R0557:Olfr108 UTSW 17 37445821 missense probably damaging 1.00
R1709:Olfr108 UTSW 17 37446200 nonsense probably null
R3076:Olfr108 UTSW 17 37445484 start gained probably benign
R5467:Olfr108 UTSW 17 37446082 missense probably damaging 1.00
R5642:Olfr108 UTSW 17 37445772 missense probably damaging 1.00
R5916:Olfr108 UTSW 17 37445679 missense probably benign 0.16
R7451:Olfr108 UTSW 17 37446305 missense probably damaging 1.00
R8205:Olfr108 UTSW 17 37446289 missense probably damaging 1.00
R8280:Olfr108 UTSW 17 37445853 missense probably benign 0.11
R9748:Olfr108 UTSW 17 37445704 missense probably benign 0.00
Posted On 2015-04-16