Incidental Mutation 'IGL02291:Olfr871'
ID 290313
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr871
Ensembl Gene ENSMUSG00000061457
Gene Name olfactory receptor 871
Synonyms GA_x6K02T2PVTD-13952555-13953490, MOR141-2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.083) question?
Stock # IGL02291
Quality Score
Status
Chromosome 9
Chromosomal Location 20212207-20213353 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 20212802 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 151 (I151T)
Ref Sequence ENSEMBL: ENSMUSP00000072865 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073122]
AlphaFold Q7TRF0
Predicted Effect probably benign
Transcript: ENSMUST00000073122
AA Change: I151T

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000072865
Gene: ENSMUSG00000061457
AA Change: I151T

DomainStartEndE-ValueType
Pfam:7tm_4 31 311 8.3e-52 PFAM
Pfam:7TM_GPCR_Srsx 35 304 2.1e-7 PFAM
Pfam:7tm_1 41 290 9.1e-28 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000158891
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AF366264 T A 8: 13,837,704 N129I probably benign Het
Arhgap10 T A 8: 77,382,715 probably benign Het
Cfap161 C T 7: 83,791,639 G135D probably benign Het
Cpne1 A G 2: 156,078,420 V179A probably damaging Het
Cpsf1 A T 15: 76,602,821 I219N probably damaging Het
Creb3l4 T G 3: 90,241,983 R139S probably benign Het
Fer1l4 T C 2: 156,019,538 K1929E probably damaging Het
Gm5431 A G 11: 48,888,964 L655P probably damaging Het
Igsf3 T G 3: 101,439,529 H613Q probably damaging Het
Kcnab1 T C 3: 65,357,082 Y251H possibly damaging Het
Kmt2d T C 15: 98,865,492 probably benign Het
Krt17 A T 11: 100,256,493 V404E probably benign Het
Lipo2 A G 19: 33,745,792 I199T possibly damaging Het
Mks1 T A 11: 87,859,667 probably benign Het
Nlrp1a A T 11: 71,122,589 probably null Het
Nup210 T C 6: 91,101,268 D100G probably damaging Het
Olfr108 G A 17: 37,446,285 V255I possibly damaging Het
Olfr1393 T A 11: 49,280,985 I279N probably damaging Het
Olfr532 A T 7: 140,419,287 L162Q probably damaging Het
Psmd5 A G 2: 34,857,799 V282A probably benign Het
Rasal3 A T 17: 32,393,737 probably benign Het
Rnf10 T C 5: 115,260,196 N93D probably damaging Het
Slc7a9 G A 7: 35,457,014 G294R probably damaging Het
Taf7 C T 18: 37,643,362 G51R possibly damaging Het
Tas2r126 G A 6: 42,435,287 M251I probably benign Het
Trim33 T C 3: 103,326,865 F473S probably damaging Het
Vmn1r127 A G 7: 21,319,074 L263P possibly damaging Het
Vmn1r234 G A 17: 21,228,931 V36I probably benign Het
Vmn2r84 T A 10: 130,390,748 H407L probably damaging Het
Other mutations in Olfr871
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01977:Olfr871 APN 9 20212459 missense possibly damaging 0.89
IGL02312:Olfr871 APN 9 20213081 missense probably damaging 1.00
IGL02345:Olfr871 APN 9 20213018 missense possibly damaging 0.88
R0278:Olfr871 UTSW 9 20212886 missense probably damaging 1.00
R0520:Olfr871 UTSW 9 20212495 missense probably benign 0.01
R1606:Olfr871 UTSW 9 20212946 missense probably benign 0.05
R3751:Olfr871 UTSW 9 20213260 missense probably damaging 0.98
R4701:Olfr871 UTSW 9 20212625 missense probably damaging 1.00
R4811:Olfr871 UTSW 9 20212753 missense probably damaging 1.00
R5074:Olfr871 UTSW 9 20212582 missense possibly damaging 0.63
R5406:Olfr871 UTSW 9 20213158 missense probably benign 0.08
R6541:Olfr871 UTSW 9 20212399 missense probably benign 0.01
R6730:Olfr871 UTSW 9 20212502 missense probably benign 0.04
R7195:Olfr871 UTSW 9 20212544 missense probably damaging 0.99
R7197:Olfr871 UTSW 9 20212555 missense probably benign 0.00
R7384:Olfr871 UTSW 9 20212745 missense probably damaging 1.00
R7715:Olfr871 UTSW 9 20212435 missense probably damaging 0.97
R7715:Olfr871 UTSW 9 20212436 missense probably benign 0.06
R8108:Olfr871 UTSW 9 20212451 missense possibly damaging 0.62
R8409:Olfr871 UTSW 9 20212246 start gained probably benign
R8861:Olfr871 UTSW 9 20213081 missense probably damaging 1.00
R9147:Olfr871 UTSW 9 20213062 missense probably damaging 1.00
R9148:Olfr871 UTSW 9 20213062 missense probably damaging 1.00
R9154:Olfr871 UTSW 9 20212877 missense possibly damaging 0.87
R9665:Olfr871 UTSW 9 20213106 nonsense probably null
R9743:Olfr871 UTSW 9 20212544 missense probably damaging 0.99
RF013:Olfr871 UTSW 9 20212894 missense probably benign 0.00
Z1176:Olfr871 UTSW 9 20212844 missense possibly damaging 0.94
Z1177:Olfr871 UTSW 9 20213186 missense probably damaging 1.00
Posted On 2015-04-16