Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02291:Tas2r126'

290314

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tas2r126

Ensembl Gene

Gene Name

taste receptor, type 2, member 126

Synonyms

T2R12, mt2r35, T2R26, mGR26, Tas2r26

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.057) question?

Stock #

IGL02291

Quality Score

Status

Chromosome

Chromosomal Location

42434535-42435464 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 42435287 bp

Zygosity

Heterozygous

Amino Acid Change

Methionine to Isoleucine at position 251 (M251I)

Ref Sequence

ENSEMBL: ENSMUSP00000056581 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000059534]

Predicted Effect

probably benign
Transcript: ENSMUST00000059534
AA Change: M251I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000056581
Gene: ENSMUSG00000048284
AA Change: M251I

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	303	2.5e-97	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 29 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
AF366264	T	A	8: 13,837,704	N129I	probably benign	Het
Arhgap10	T	A	8: 77,382,715		probably benign	Het
Cfap161	C	T	7: 83,791,639	G135D	probably benign	Het
Cpne1	A	G	2: 156,078,420	V179A	probably damaging	Het
Cpsf1	A	T	15: 76,602,821	I219N	probably damaging	Het
Creb3l4	T	G	3: 90,241,983	R139S	probably benign	Het
Fer1l4	T	C	2: 156,019,538	K1929E	probably damaging	Het
Gm5431	A	G	11: 48,888,964	L655P	probably damaging	Het
Igsf3	T	G	3: 101,439,529	H613Q	probably damaging	Het
Kcnab1	T	C	3: 65,357,082	Y251H	possibly damaging	Het
Kmt2d	T	C	15: 98,865,492		probably benign	Het
Krt17	A	T	11: 100,256,493	V404E	probably benign	Het
Lipo2	A	G	19: 33,745,792	I199T	possibly damaging	Het
Mks1	T	A	11: 87,859,667		probably benign	Het
Nlrp1a	A	T	11: 71,122,589		probably null	Het
Nup210	T	C	6: 91,101,268	D100G	probably damaging	Het
Olfr108	G	A	17: 37,446,285	V255I	possibly damaging	Het
Olfr1393	T	A	11: 49,280,985	I279N	probably damaging	Het
Olfr532	A	T	7: 140,419,287	L162Q	probably damaging	Het
Olfr871	T	C	9: 20,212,802	I151T	probably benign	Het
Psmd5	A	G	2: 34,857,799	V282A	probably benign	Het
Rasal3	A	T	17: 32,393,737		probably benign	Het
Rnf10	T	C	5: 115,260,196	N93D	probably damaging	Het
Slc7a9	G	A	7: 35,457,014	G294R	probably damaging	Het
Taf7	C	T	18: 37,643,362	G51R	possibly damaging	Het
Trim33	T	C	3: 103,326,865	F473S	probably damaging	Het
Vmn1r127	A	G	7: 21,319,074	L263P	possibly damaging	Het
Vmn1r234	G	A	17: 21,228,931	V36I	probably benign	Het
Vmn2r84	T	A	10: 130,390,748	H407L	probably damaging	Het

Other mutations in Tas2r126

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00915:Tas2r126	APN	6	42435349	missense	possibly damaging	0.67
IGL01327:Tas2r126	APN	6	42434750	missense	probably benign	0.09
IGL01690:Tas2r126	APN	6	42435307	missense	probably benign	0.02
IGL02153:Tas2r126	APN	6	42434664	missense	probably benign	0.32
IGL03365:Tas2r126	APN	6	42435457	missense	probably benign	0.36
R0091:Tas2r126	UTSW	6	42435102	missense	probably benign
R0486:Tas2r126	UTSW	6	42435291	missense	probably benign	0.01
R0611:Tas2r126	UTSW	6	42435091	missense	probably damaging	0.99
R1527:Tas2r126	UTSW	6	42435136	missense	probably benign	0.03
R1529:Tas2r126	UTSW	6	42434568	missense	probably benign	0.00
R1883:Tas2r126	UTSW	6	42435027	missense	probably benign
R1884:Tas2r126	UTSW	6	42435027	missense	probably benign
R2039:Tas2r126	UTSW	6	42434623	missense	probably benign	0.22
R4863:Tas2r126	UTSW	6	42435390	missense	probably benign	0.02
R5975:Tas2r126	UTSW	6	42435000	missense	possibly damaging	0.69
R7127:Tas2r126	UTSW	6	42434805	missense	probably damaging	1.00
R7351:Tas2r126	UTSW	6	42435306	missense	probably benign	0.02
R7714:Tas2r126	UTSW	6	42435097	missense	probably benign	0.12

Posted On

2015-04-16