Incidental Mutation 'IGL02291:Vmn1r127'
ID 290317
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r127
Ensembl Gene ENSMUSG00000093890
Gene Name vomeronasal 1 receptor 127
Synonyms Gm6239
Accession Numbers
Is this an essential gene? Not available question?
Stock # IGL02291
Quality Score
Status
Chromosome 7
Chromosomal Location 21318944-21319861 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 21319074 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 263 (L263P)
Ref Sequence ENSEMBL: ENSMUSP00000100834 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105199]
AlphaFold K7N6J5
Predicted Effect possibly damaging
Transcript: ENSMUST00000105199
AA Change: L263P

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000100834
Gene: ENSMUSG00000093890
AA Change: L263P

DomainStartEndE-ValueType
Pfam:TAS2R 8 296 3.2e-17 PFAM
Pfam:7tm_1 40 288 3.1e-9 PFAM
Pfam:V1R 41 296 1.7e-15 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AF366264 T A 8: 13,837,704 N129I probably benign Het
Arhgap10 T A 8: 77,382,715 probably benign Het
Cfap161 C T 7: 83,791,639 G135D probably benign Het
Cpne1 A G 2: 156,078,420 V179A probably damaging Het
Cpsf1 A T 15: 76,602,821 I219N probably damaging Het
Creb3l4 T G 3: 90,241,983 R139S probably benign Het
Fer1l4 T C 2: 156,019,538 K1929E probably damaging Het
Gm5431 A G 11: 48,888,964 L655P probably damaging Het
Igsf3 T G 3: 101,439,529 H613Q probably damaging Het
Kcnab1 T C 3: 65,357,082 Y251H possibly damaging Het
Kmt2d T C 15: 98,865,492 probably benign Het
Krt17 A T 11: 100,256,493 V404E probably benign Het
Lipo2 A G 19: 33,745,792 I199T possibly damaging Het
Mks1 T A 11: 87,859,667 probably benign Het
Nlrp1a A T 11: 71,122,589 probably null Het
Nup210 T C 6: 91,101,268 D100G probably damaging Het
Olfr108 G A 17: 37,446,285 V255I possibly damaging Het
Olfr1393 T A 11: 49,280,985 I279N probably damaging Het
Olfr532 A T 7: 140,419,287 L162Q probably damaging Het
Olfr871 T C 9: 20,212,802 I151T probably benign Het
Psmd5 A G 2: 34,857,799 V282A probably benign Het
Rasal3 A T 17: 32,393,737 probably benign Het
Rnf10 T C 5: 115,260,196 N93D probably damaging Het
Slc7a9 G A 7: 35,457,014 G294R probably damaging Het
Taf7 C T 18: 37,643,362 G51R possibly damaging Het
Tas2r126 G A 6: 42,435,287 M251I probably benign Het
Trim33 T C 3: 103,326,865 F473S probably damaging Het
Vmn1r234 G A 17: 21,228,931 V36I probably benign Het
Vmn2r84 T A 10: 130,390,748 H407L probably damaging Het
Other mutations in Vmn1r127
AlleleSourceChrCoordTypePredicted EffectPPH Score
R4994:Vmn1r127 UTSW 7 21319018 missense probably damaging 1.00
R6264:Vmn1r127 UTSW 7 21319005 missense probably benign 0.06
R7301:Vmn1r127 UTSW 7 21319053 missense probably benign 0.36
R9287:Vmn1r127 UTSW 7 21319002 missense possibly damaging 0.95
Posted On 2015-04-16