Incidental Mutation 'IGL02291:Or2y1g'
ID 290318
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or2y1g
Ensembl Gene ENSMUSG00000059864
Gene Name olfactory receptor family 2 subfamily Y member 1G
Synonyms Olfr1393, MOR256-24, GA_x6K02T2QP88-6154577-6153642, MOR256-67_i
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # IGL02291
Quality Score
Status
Chromosome 11
Chromosomal Location 49169131-49173596 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 49171812 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 279 (I279N)
Ref Sequence ENSEMBL: ENSMUSP00000149358 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078932] [ENSMUST00000213323] [ENSMUST00000214170] [ENSMUST00000214598] [ENSMUST00000215861] [ENSMUST00000217275]
AlphaFold Q8VFA7
Predicted Effect probably damaging
Transcript: ENSMUST00000078932
AA Change: I279N

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000077962
Gene: ENSMUSG00000059864
AA Change: I279N

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.3e-48 PFAM
Pfam:7TM_GPCR_Srsx 35 230 3e-6 PFAM
Pfam:7tm_1 41 289 5.8e-25 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213323
AA Change: I279N

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213684
Predicted Effect probably benign
Transcript: ENSMUST00000214170
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214516
Predicted Effect probably benign
Transcript: ENSMUST00000214598
Predicted Effect probably benign
Transcript: ENSMUST00000215861
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217626
Predicted Effect probably benign
Transcript: ENSMUST00000217275
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap10 T A 8: 78,109,344 (GRCm39) probably benign Het
Cfap161 C T 7: 83,440,847 (GRCm39) G135D probably benign Het
Cpne1 A G 2: 155,920,340 (GRCm39) V179A probably damaging Het
Cpsf1 A T 15: 76,487,021 (GRCm39) I219N probably damaging Het
Creb3l4 T G 3: 90,149,290 (GRCm39) R139S probably benign Het
Fer1l4 T C 2: 155,861,458 (GRCm39) K1929E probably damaging Het
Gm5431 A G 11: 48,779,791 (GRCm39) L655P probably damaging Het
Igsf3 T G 3: 101,346,845 (GRCm39) H613Q probably damaging Het
Kcnab1 T C 3: 65,264,503 (GRCm39) Y251H possibly damaging Het
Kmt2d T C 15: 98,763,373 (GRCm39) probably benign Het
Krt17 A T 11: 100,147,319 (GRCm39) V404E probably benign Het
Lipo2 A G 19: 33,723,192 (GRCm39) I199T possibly damaging Het
Mks1 T A 11: 87,750,493 (GRCm39) probably benign Het
Nlrp1a A T 11: 71,013,415 (GRCm39) probably null Het
Nup210 T C 6: 91,078,250 (GRCm39) D100G probably damaging Het
Or13a21 A T 7: 139,999,200 (GRCm39) L162Q probably damaging Het
Or1o11 G A 17: 37,757,176 (GRCm39) V255I possibly damaging Het
Or7h8 T C 9: 20,124,098 (GRCm39) I151T probably benign Het
Psmd5 A G 2: 34,747,811 (GRCm39) V282A probably benign Het
Rasal3 A T 17: 32,612,711 (GRCm39) probably benign Het
Rnf10 T C 5: 115,398,255 (GRCm39) N93D probably damaging Het
Semp2l2a T A 8: 13,887,704 (GRCm39) N129I probably benign Het
Slc7a9 G A 7: 35,156,439 (GRCm39) G294R probably damaging Het
Taf7 C T 18: 37,776,415 (GRCm39) G51R possibly damaging Het
Tas2r126 G A 6: 42,412,221 (GRCm39) M251I probably benign Het
Trim33 T C 3: 103,234,181 (GRCm39) F473S probably damaging Het
Vmn1r127 A G 7: 21,052,999 (GRCm39) L263P possibly damaging Het
Vmn1r234 G A 17: 21,449,193 (GRCm39) V36I probably benign Het
Vmn2r84 T A 10: 130,226,617 (GRCm39) H407L probably damaging Het
Other mutations in Or2y1g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01401:Or2y1g APN 11 49,171,314 (GRCm39) missense possibly damaging 0.94
IGL03127:Or2y1g APN 11 49,171,599 (GRCm39) missense possibly damaging 0.88
R0580:Or2y1g UTSW 11 49,171,449 (GRCm39) missense probably damaging 0.97
R1985:Or2y1g UTSW 11 49,171,110 (GRCm39) missense probably damaging 1.00
R4812:Or2y1g UTSW 11 49,171,284 (GRCm39) missense possibly damaging 0.94
R5190:Or2y1g UTSW 11 49,171,209 (GRCm39) missense probably damaging 0.99
R6694:Or2y1g UTSW 11 49,171,379 (GRCm39) missense probably benign 0.01
R6911:Or2y1g UTSW 11 49,171,634 (GRCm39) missense probably benign 0.22
R7012:Or2y1g UTSW 11 49,171,823 (GRCm39) missense probably benign 0.07
R7159:Or2y1g UTSW 11 49,171,185 (GRCm39) missense probably damaging 1.00
R7541:Or2y1g UTSW 11 49,171,160 (GRCm39) missense probably damaging 1.00
R7759:Or2y1g UTSW 11 49,171,463 (GRCm39) missense probably benign 0.00
R8767:Or2y1g UTSW 11 49,171,227 (GRCm39) missense possibly damaging 0.87
R9069:Or2y1g UTSW 11 49,171,247 (GRCm39) missense probably benign 0.03
Posted On 2015-04-16