Incidental Mutation 'IGL02359:Sult2a5'
ID290404
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Sult2a5
Ensembl Gene ENSMUSG00000078799
Gene Namesulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 5
SynonymsGm15438, EG434264
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.082) question?
Stock #IGL02359
Quality Score
Status
Chromosome7
Chromosomal Location13623967-13670807 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 13628802 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 145 (S145P)
Ref Sequence ENSEMBL: ENSMUSP00000104165 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108525]
Predicted Effect probably benign
Transcript: ENSMUST00000108525
AA Change: S145P

PolyPhen 2 Score 0.102 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000104165
Gene: ENSMUSG00000078799
AA Change: S145P

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 34 278 2e-82 PFAM
Pfam:Sulfotransfer_3 35 205 3.3e-12 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This is one of seven sulfotransferase family 2A genes in a chromosome 7 A1 cluster. [provided by RefSeq, May 2010]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930447C04Rik A C 12: 72,895,055 probably null Het
Abca5 T A 11: 110,275,330 N1540I probably benign Het
Adamtsl5 T A 10: 80,343,728 probably null Het
Aldh2 T C 5: 121,575,897 E128G probably null Het
Ano3 A T 2: 110,884,943 L50* probably null Het
Atp13a3 A G 16: 30,351,084 I392T probably damaging Het
C1qtnf5 A G 9: 44,108,334 E85G possibly damaging Het
Cacna1s A T 1: 136,093,252 probably benign Het
Ccdc150 G A 1: 54,272,521 R222H probably benign Het
Cep55 T A 19: 38,069,868 I303N probably damaging Het
Cmip A T 8: 117,411,255 probably benign Het
Cyp21a1 A G 17: 34,804,222 Y60H probably damaging Het
Cyp2d11 A G 15: 82,393,920 W10R possibly damaging Het
Dock10 A G 1: 80,505,661 Y2076H probably damaging Het
Egflam T C 15: 7,234,225 N748S probably benign Het
Fam227b A G 2: 126,146,254 probably benign Het
Fancd2 T A 6: 113,563,112 I654N probably damaging Het
Gm17018 G T 19: 45,577,054 A156S probably benign Het
Gm17727 A T 9: 35,777,884 M1K probably null Het
Hpf1 A G 8: 60,896,802 I155V probably benign Het
Hrh1 C A 6: 114,480,443 N228K probably benign Het
Igkv3-2 T C 6: 70,698,490 L8P probably damaging Het
Iqgap3 T C 3: 88,101,960 F734L probably benign Het
Kif5a T C 10: 127,243,501 Y276C probably damaging Het
Lax1 A T 1: 133,680,470 S178T possibly damaging Het
March6 C T 15: 31,509,759 C28Y probably damaging Het
Mylk3 T C 8: 85,355,302 T356A probably benign Het
Olfr166 T C 16: 19,487,177 L113P probably damaging Het
Pgap2 G T 7: 102,236,139 V71F probably damaging Het
Prob1 T G 18: 35,652,840 E787A possibly damaging Het
Psmd2 C A 16: 20,656,941 D430E probably benign Het
Reln C A 5: 22,039,565 G805V possibly damaging Het
Serpinb9e A T 13: 33,257,820 probably benign Het
Sgsm2 G T 11: 74,892,074 probably benign Het
Slc38a9 A G 13: 112,690,186 I153V probably benign Het
Slco1b2 T A 6: 141,685,525 D628E probably damaging Het
Sv2b T C 7: 75,136,449 T408A probably benign Het
Usp24 T C 4: 106,403,925 C1626R probably damaging Het
Wdr43 C T 17: 71,632,048 T217M possibly damaging Het
Wdr95 G A 5: 149,580,619 V155M probably damaging Het
Wsb1 G A 11: 79,251,012 L60F probably damaging Het
Wwp2 C T 8: 107,540,646 R297* probably null Het
Xkr6 T C 14: 63,819,707 Y356H unknown Het
Other mutations in Sult2a5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01757:Sult2a5 APN 7 13665154 missense probably damaging 1.00
IGL02352:Sult2a5 APN 7 13628802 missense probably benign 0.10
IGL02453:Sult2a5 APN 7 13662507 missense possibly damaging 0.66
IGL03062:Sult2a5 APN 7 13624182 critical splice donor site probably null
R0285:Sult2a5 UTSW 7 13628760 missense probably damaging 1.00
R0918:Sult2a5 UTSW 7 13625409 missense probably benign 0.12
R1869:Sult2a5 UTSW 7 13624120 missense probably benign 0.01
R1917:Sult2a5 UTSW 7 13670684 missense probably damaging 1.00
R2117:Sult2a5 UTSW 7 13625434 missense probably damaging 1.00
R4867:Sult2a5 UTSW 7 13624051 missense probably benign 0.02
R4890:Sult2a5 UTSW 7 13625386 missense probably benign 0.06
R4901:Sult2a5 UTSW 7 13625263 missense probably benign 0.10
R5236:Sult2a5 UTSW 7 13665049 missense probably benign
R6355:Sult2a5 UTSW 7 13662537 missense probably benign 0.00
R6692:Sult2a5 UTSW 7 13624132 missense probably damaging 0.99
R6735:Sult2a5 UTSW 7 13665058 nonsense probably null
R6873:Sult2a5 UTSW 7 13625386 missense probably benign 0.00
R7616:Sult2a5 UTSW 7 13670682 missense probably benign
R7828:Sult2a5 UTSW 7 13628843 critical splice donor site probably null
X0024:Sult2a5 UTSW 7 13665216 critical splice donor site probably null
Posted On2015-04-16