Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02360:Krt87'

290452

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Krt87

Ensembl Gene

ENSMUSG00000047641

Gene Name

keratin 87

Synonyms

Krt2-25, Krt83

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

IGL02360

Quality Score

Status

Chromosome

Chromosomal Location

101329371-101336685 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 101383339 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Glycine at position 456 (S456G)

Ref Sequence

ENSEMBL: ENSMUSP00000023718 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023718]

AlphaFold

Q6IMF0

Predicted Effect

probably benign
Transcript: ENSMUST00000023718
AA Change: S456G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000023718
Gene: ENSMUSG00000067613
AA Change: S456G

Domain	Start	End	E-Value	Type
Pfam:Keratin_2_head	2	100	5.9e-16	PFAM
Filament	103	414	7.02e-149	SMART
low complexity region	422	436	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000159029

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000230173

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aldh18a1	A	T	19: 40,566,364 (GRCm39)	V102D	probably damaging	Het
Car4	C	T	11: 84,856,593 (GRCm39)	P294S	probably damaging	Het
Casp6	C	T	3: 129,704,175 (GRCm39)	S87L	probably damaging	Het
Ccdc121rt1	T	C	1: 181,338,190 (GRCm39)	E254G	possibly damaging	Het
Ccnl1	A	C	3: 65,856,141 (GRCm39)	C255G	probably damaging	Het
Celf4	T	C	18: 25,619,955 (GRCm39)	I485M	probably damaging	Het
Cntln	A	G	4: 84,968,087 (GRCm39)	R769G	probably damaging	Het
Cyp2d12	T	C	15: 82,443,171 (GRCm39)	V360A	probably benign	Het
Dgki	T	C	6: 36,824,324 (GRCm39)	E1068G	probably damaging	Het
Fbxl4	A	G	4: 22,433,684 (GRCm39)	N607S	probably benign	Het
Fgd4	T	C	16: 16,279,909 (GRCm39)	I383V	probably damaging	Het
Fgd6	C	T	10: 93,974,258 (GRCm39)	T1333I	possibly damaging	Het
Got1	A	G	19: 43,512,882 (GRCm39)	S5P	probably damaging	Het
Herc2	T	A	7: 55,764,560 (GRCm39)	N995K	probably damaging	Het
Kcnma1	A	G	14: 23,641,681 (GRCm39)	F159S	probably damaging	Het
Lhb	T	C	7: 45,070,718 (GRCm39)	V32A	possibly damaging	Het
Mau2	A	T	8: 70,472,288 (GRCm39)	V602E	probably damaging	Het
Mpst	C	T	15: 78,294,285 (GRCm39)	L6F	probably damaging	Het
Nlrp2	G	A	7: 5,340,598 (GRCm39)	T72I	probably damaging	Het
Or8g20	A	G	9: 39,396,444 (GRCm39)	I32T	probably benign	Het
Phldb2	T	C	16: 45,569,142 (GRCm39)	Y1239C	probably damaging	Het
Slc22a8	T	C	19: 8,585,619 (GRCm39)	F328S	possibly damaging	Het
Sult2a3	G	A	7: 13,855,575 (GRCm39)	R94*	probably null	Het
Syt16	A	G	12: 74,176,245 (GRCm39)	N38S	probably damaging	Het
Tbc1d1	G	A	5: 64,414,179 (GRCm39)	R180Q	probably damaging	Het
Ush2a	T	C	1: 188,460,635 (GRCm39)	I2632T	probably benign	Het
Vcam1	T	A	3: 115,909,543 (GRCm39)	I595F	possibly damaging	Het

Other mutations in Krt87

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00481:Krt87	APN	15	101,386,092 (GRCm39)	missense	probably benign	0.17
IGL00987:Krt87	APN	15	101,336,327 (GRCm39)	missense	probably benign	0.00
IGL01019:Krt87	APN	15	101,336,312 (GRCm39)	missense	possibly damaging	0.84
IGL01066:Krt87	APN	15	101,336,266 (GRCm39)	critical splice donor site	probably null
IGL01087:Krt87	APN	15	101,329,706 (GRCm39)	missense	probably benign	0.27
IGL01315:Krt87	APN	15	101,384,848 (GRCm39)	splice site	probably benign
IGL01572:Krt87	APN	15	101,334,414 (GRCm39)	missense	probably benign	0.33
IGL01702:Krt87	APN	15	101,389,099 (GRCm39)	missense	probably benign	0.18
IGL02123:Krt87	APN	15	101,385,466 (GRCm39)	missense	possibly damaging	0.49
IGL02353:Krt87	APN	15	101,383,339 (GRCm39)	missense	probably benign
IGL02395:Krt87	APN	15	101,385,833 (GRCm39)	missense	probably benign	0.18
IGL02633:Krt87	APN	15	101,389,095 (GRCm39)	missense	probably damaging	1.00
IGL02716:Krt87	APN	15	101,332,485 (GRCm39)	missense	possibly damaging	0.52
IGL03287:Krt87	APN	15	101,330,218 (GRCm39)	splice site	probably benign
R0144:Krt87	UTSW	15	101,336,542 (GRCm39)	missense	probably benign	0.04
R0357:Krt87	UTSW	15	101,384,900 (GRCm39)	missense	probably benign	0.17
R0650:Krt87	UTSW	15	101,384,921 (GRCm39)	missense	probably damaging	0.99
R0928:Krt87	UTSW	15	101,389,161 (GRCm39)	missense	probably benign	0.00
R1126:Krt87	UTSW	15	101,385,363 (GRCm39)	missense	probably damaging	0.98
R1196:Krt87	UTSW	15	101,389,314 (GRCm39)	missense	probably benign	0.03
R1252:Krt87	UTSW	15	101,385,711 (GRCm39)	missense	probably damaging	1.00
R1513:Krt87	UTSW	15	101,387,538 (GRCm39)	missense	probably benign	0.30
R1612:Krt87	UTSW	15	101,386,092 (GRCm39)	missense	probably benign	0.17
R1870:Krt87	UTSW	15	101,385,071 (GRCm39)	missense	probably benign
R2173:Krt87	UTSW	15	101,385,818 (GRCm39)	missense	probably damaging	0.98
R2196:Krt87	UTSW	15	101,336,314 (GRCm39)	missense	probably damaging	0.99
R2209:Krt87	UTSW	15	101,330,989 (GRCm39)	missense	probably benign	0.42
R2432:Krt87	UTSW	15	101,386,037 (GRCm39)	nonsense	probably null
R2568:Krt87	UTSW	15	101,385,708 (GRCm39)	missense	possibly damaging	0.67
R2696:Krt87	UTSW	15	101,384,890 (GRCm39)	missense	probably benign	0.01
R3508:Krt87	UTSW	15	101,386,039 (GRCm39)	missense	probably benign	0.04
R4364:Krt87	UTSW	15	101,385,395 (GRCm39)	missense	probably benign
R4366:Krt87	UTSW	15	101,385,395 (GRCm39)	missense	probably benign
R4606:Krt87	UTSW	15	101,384,930 (GRCm39)	missense	probably benign	0.18
R4721:Krt87	UTSW	15	101,385,863 (GRCm39)	missense	probably damaging	1.00
R4784:Krt87	UTSW	15	101,385,837 (GRCm39)	missense	probably damaging	1.00
R4987:Krt87	UTSW	15	101,384,890 (GRCm39)	missense	probably benign
R5008:Krt87	UTSW	15	101,389,105 (GRCm39)	missense	probably damaging	1.00
R5101:Krt87	UTSW	15	101,385,391 (GRCm39)	missense	probably benign	0.14
R5367:Krt87	UTSW	15	101,384,875 (GRCm39)	missense	probably damaging	1.00
R5516:Krt87	UTSW	15	101,385,002 (GRCm39)	nonsense	probably null
R5651:Krt87	UTSW	15	101,331,910 (GRCm39)	missense	possibly damaging	0.94
R5949:Krt87	UTSW	15	101,385,476 (GRCm39)	missense	probably damaging	0.99
R5972:Krt87	UTSW	15	101,385,467 (GRCm39)	missense	probably benign
R6036:Krt87	UTSW	15	101,385,412 (GRCm39)	missense	possibly damaging	0.78
R6036:Krt87	UTSW	15	101,385,412 (GRCm39)	missense	possibly damaging	0.78
R6135:Krt87	UTSW	15	101,385,415 (GRCm39)	missense	probably damaging	1.00
R6437:Krt87	UTSW	15	101,336,273 (GRCm39)	missense	possibly damaging	0.95
R6615:Krt87	UTSW	15	101,334,443 (GRCm39)	missense	probably benign	0.02
R6680:Krt87	UTSW	15	101,331,859 (GRCm39)	missense	probably damaging	1.00
R7151:Krt87	UTSW	15	101,387,529 (GRCm39)	missense	probably damaging	1.00
R7186:Krt87	UTSW	15	101,385,083 (GRCm39)	splice site	probably null
R7297:Krt87	UTSW	15	101,387,528 (GRCm39)	missense	probably benign	0.42
R7541:Krt87	UTSW	15	101,336,515 (GRCm39)	missense	probably damaging	1.00
R7617:Krt87	UTSW	15	101,336,426 (GRCm39)	missense	probably benign	0.38
R7708:Krt87	UTSW	15	101,385,813 (GRCm39)	missense	probably benign	0.00
R7796:Krt87	UTSW	15	101,383,865 (GRCm39)	missense	possibly damaging	0.95
R8172:Krt87	UTSW	15	101,383,284 (GRCm39)	missense	probably benign	0.25
R8463:Krt87	UTSW	15	101,332,506 (GRCm39)	missense	probably benign	0.05
R8669:Krt87	UTSW	15	101,385,777 (GRCm39)	missense	probably benign	0.00
R8695:Krt87	UTSW	15	101,331,901 (GRCm39)	missense	probably benign	0.00
R8771:Krt87	UTSW	15	101,385,779 (GRCm39)	missense	probably benign	0.00
R9478:Krt87	UTSW	15	101,385,449 (GRCm39)	missense	probably benign	0.06
R9489:Krt87	UTSW	15	101,336,484 (GRCm39)	nonsense	probably null
R9592:Krt87	UTSW	15	101,386,060 (GRCm39)	missense	probably benign
R9605:Krt87	UTSW	15	101,336,484 (GRCm39)	nonsense	probably null
R9629:Krt87	UTSW	15	101,389,048 (GRCm39)	missense	probably benign	0.01
R9642:Krt87	UTSW	15	101,385,074 (GRCm39)	missense	probably benign	0.00

Posted On

2015-04-16