Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02361:Lrrc25'

290492

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lrrc25

Ensembl Gene

ENSMUSG00000049988

Gene Name

leucine rich repeat containing 25

Synonyms

Mapa

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.097) question?

Stock #

IGL02361

Quality Score

Status

Chromosome

Chromosomal Location

71068810-71073501 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 71070477 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Valine at position 86 (D86V)

Ref Sequence

ENSEMBL: ENSMUSP00000049686 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000052437] [ENSMUST00000210609]

AlphaFold

Q8K1T1

Predicted Effect

probably benign
Transcript: ENSMUST00000052437
AA Change: D86V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000049686
Gene: ENSMUSG00000049988
AA Change: D86V

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
low complexity region	51	62	N/A	INTRINSIC
Pfam:LRR_8	65	110	9.6e-8	PFAM
transmembrane domain	169	191	N/A	INTRINSIC
low complexity region	192	199	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000210609

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aqp1	A	C	6: 55,322,498 (GRCm39)	L164F	possibly damaging	Het
Bfsp1	T	C	2: 143,673,907 (GRCm39)	E261G	probably damaging	Het
Brinp2	A	G	1: 158,074,748 (GRCm39)	C458R	probably damaging	Het
Cacng3	T	G	7: 122,271,169 (GRCm39)	M58R	possibly damaging	Het
Cfap43	A	T	19: 47,885,852 (GRCm39)	C254*	probably null	Het
Cnga1	T	C	5: 72,774,061 (GRCm39)		probably null	Het
Dis3	A	T	14: 99,317,148 (GRCm39)	Y765*	probably null	Het
Dpep1	T	A	8: 123,926,957 (GRCm39)	S260R	probably benign	Het
Elmod1	A	G	9: 53,838,842 (GRCm39)	L106P	probably damaging	Het
Fut10	A	G	8: 31,691,398 (GRCm39)	Y81C	probably damaging	Het
Fzd10	T	A	5: 128,678,932 (GRCm39)	D217E	possibly damaging	Het
Gap43	T	C	16: 42,160,871 (GRCm39)		probably benign	Het
Gigyf1	T	C	5: 137,517,989 (GRCm39)		probably benign	Het
Gpc5	C	T	14: 115,370,699 (GRCm39)	R175*	probably null	Het
Gpi-ps	T	C	8: 5,690,896 (GRCm39)		noncoding transcript	Het
Kcna1	C	A	6: 126,619,869 (GRCm39)	Q150H	probably damaging	Het
Lama5	A	T	2: 179,835,677 (GRCm39)	C1225*	probably null	Het
Madd	A	T	2: 90,992,543 (GRCm39)	V1043E	probably benign	Het
Mov10	A	T	3: 104,711,437 (GRCm39)		probably benign	Het
Mzb1	T	A	18: 35,782,250 (GRCm39)	H46L	possibly damaging	Het
Nek10	A	T	14: 14,843,856 (GRCm38)	Q193L	probably damaging	Het
Nos3	A	T	5: 24,572,621 (GRCm39)	I187F	probably damaging	Het
Or4c1	T	A	2: 89,133,526 (GRCm39)	M137L	probably benign	Het
Or5p53	T	A	7: 107,533,484 (GRCm39)	Y252*	probably null	Het
Or6c69c	A	G	10: 129,911,143 (GRCm39)	Y288C	probably damaging	Het
Pgap1	T	C	1: 54,551,975 (GRCm39)	T486A	probably benign	Het
Prdm9	C	T	17: 15,783,109 (GRCm39)	V58M	probably damaging	Het
Prkd2	A	G	7: 16,581,583 (GRCm39)	Y146C	probably damaging	Het
Psmd9	G	T	5: 123,386,379 (GRCm39)	R175I	probably damaging	Het
Pxdn	A	G	12: 30,049,188 (GRCm39)	D618G	probably damaging	Het
Rgs6	A	T	12: 82,665,393 (GRCm39)		probably benign	Het
Rrm2	G	T	12: 24,761,438 (GRCm39)		probably benign	Het
Shank3	T	C	15: 89,388,536 (GRCm39)	V376A	probably damaging	Het
Slc5a10	A	G	11: 61,610,666 (GRCm39)		probably null	Het
Slfn3	A	T	11: 83,104,068 (GRCm39)	Q313L	possibly damaging	Het
Sptbn1	A	T	11: 30,060,783 (GRCm39)	F2062L	probably damaging	Het
Tbc1d10a	T	C	11: 4,165,047 (GRCm39)	V500A	probably benign	Het
Tcea1	T	C	1: 4,966,570 (GRCm39)		probably benign	Het
Thsd7a	T	C	6: 12,348,192 (GRCm39)		probably benign	Het
Tm9sf4	C	T	2: 153,029,570 (GRCm39)	T173M	probably benign	Het
Tmtc2	T	C	10: 105,107,387 (GRCm39)	T709A	probably benign	Het
Zfp385b	T	C	2: 77,280,647 (GRCm39)	E97G	probably damaging	Het
Zim1	A	T	7: 6,685,873 (GRCm39)		probably null	Het

Other mutations in Lrrc25

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01870:Lrrc25	APN	8	71,070,437 (GRCm39)	missense	possibly damaging	0.83
IGL02263:Lrrc25	APN	8	71,070,472 (GRCm39)	missense	probably benign	0.27
IGL02354:Lrrc25	APN	8	71,070,477 (GRCm39)	missense	probably benign
R0320:Lrrc25	UTSW	8	71,070,896 (GRCm39)	missense	probably benign	0.00
R1863:Lrrc25	UTSW	8	71,070,596 (GRCm39)	missense	possibly damaging	0.83
R4816:Lrrc25	UTSW	8	71,070,726 (GRCm39)	missense	probably benign
R6696:Lrrc25	UTSW	8	71,071,015 (GRCm39)	critical splice donor site	probably null
R7169:Lrrc25	UTSW	8	71,070,437 (GRCm39)	missense	probably benign	0.27
R7394:Lrrc25	UTSW	8	71,070,830 (GRCm39)	missense	possibly damaging	0.60
R7958:Lrrc25	UTSW	8	71,070,497 (GRCm39)	missense	possibly damaging	0.66
R8681:Lrrc25	UTSW	8	71,070,314 (GRCm39)	missense	possibly damaging	0.46
R8708:Lrrc25	UTSW	8	71,070,459 (GRCm39)	missense	probably damaging	0.97
R8778:Lrrc25	UTSW	8	71,070,242 (GRCm39)	missense	possibly damaging	0.66
R9281:Lrrc25	UTSW	8	71,073,246 (GRCm39)	missense	probably benign	0.04

Posted On

2015-04-16