Incidental Mutation 'IGL02361:Olfr1231'
ID 290496
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1231
Ensembl Gene ENSMUSG00000075093
Gene Name olfactory receptor 1231
Synonyms GA_x6K02T2Q125-50748233-50747292, MOR235-2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # IGL02361
Quality Score
Chromosome 2
Chromosomal Location 89299786-89307074 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 89303182 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 137 (M137L)
Ref Sequence ENSEMBL: ENSMUSP00000150310 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099786] [ENSMUST00000216144]
AlphaFold Q7TQZ8
Predicted Effect probably benign
Transcript: ENSMUST00000099786
AA Change: M137L

PolyPhen 2 Score 0.030 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000097374
Gene: ENSMUSG00000075093
AA Change: M137L

Pfam:7tm_4 32 306 7e-43 PFAM
Pfam:7tm_1 42 288 1.3e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216144
AA Change: M137L

PolyPhen 2 Score 0.030 (Sensitivity: 0.95; Specificity: 0.82)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aqp1 A C 6: 55,345,513 (GRCm38) L164F possibly damaging Het
Bfsp1 T C 2: 143,831,987 (GRCm38) E261G probably damaging Het
Brinp2 A G 1: 158,247,178 (GRCm38) C458R probably damaging Het
Cacng3 T G 7: 122,671,946 (GRCm38) M58R possibly damaging Het
Cfap43 A T 19: 47,897,413 (GRCm38) C254* probably null Het
Cnga1 T C 5: 72,616,718 (GRCm38) probably null Het
Dis3 A T 14: 99,079,712 (GRCm38) Y765* probably null Het
Dpep1 T A 8: 123,200,218 (GRCm38) S260R probably benign Het
Elmod1 A G 9: 53,931,558 (GRCm38) L106P probably damaging Het
Fut10 A G 8: 31,201,370 (GRCm38) Y81C probably damaging Het
Fzd10 T A 5: 128,601,868 (GRCm38) D217E possibly damaging Het
Gap43 T C 16: 42,340,508 (GRCm38) probably benign Het
Gigyf1 T C 5: 137,519,727 (GRCm38) probably benign Het
Gm1840 T C 8: 5,640,896 (GRCm38) noncoding transcript Het
Gpc5 C T 14: 115,133,287 (GRCm38) R175* probably null Het
Kcna1 C A 6: 126,642,906 (GRCm38) Q150H probably damaging Het
Lama5 A T 2: 180,193,884 (GRCm38) C1225* probably null Het
Lrrc25 A T 8: 70,617,827 (GRCm38) D86V probably benign Het
Madd A T 2: 91,162,198 (GRCm38) V1043E probably benign Het
Mov10 A T 3: 104,804,121 (GRCm38) probably benign Het
Mzb1 T A 18: 35,649,197 (GRCm38) H46L possibly damaging Het
Nek10 A T 14: 14,843,856 (GRCm38) Q193L probably damaging Het
Nos3 A T 5: 24,367,623 (GRCm38) I187F probably damaging Het
Olfr473 T A 7: 107,934,277 (GRCm38) Y252* probably null Het
Olfr822 A G 10: 130,075,274 (GRCm38) Y288C probably damaging Het
Pgap1 T C 1: 54,512,816 (GRCm38) T486A probably benign Het
Prdm9 C T 17: 15,562,847 (GRCm38) V58M probably damaging Het
Prkd2 A G 7: 16,847,658 (GRCm38) Y146C probably damaging Het
Psmd9 G T 5: 123,248,316 (GRCm38) R175I probably damaging Het
Pxdn A G 12: 29,999,189 (GRCm38) D618G probably damaging Het
Rgs6 A T 12: 82,618,619 (GRCm38) probably benign Het
Rrm2 G T 12: 24,711,439 (GRCm38) probably benign Het
Shank3 T C 15: 89,504,333 (GRCm38) V376A probably damaging Het
Slc5a10 A G 11: 61,719,840 (GRCm38) probably null Het
Slfn3 A T 11: 83,213,242 (GRCm38) Q313L possibly damaging Het
Sptbn1 A T 11: 30,110,783 (GRCm38) F2062L probably damaging Het
Tbc1d10a T C 11: 4,215,047 (GRCm38) V500A probably benign Het
Tcea1 T C 1: 4,896,347 (GRCm38) probably benign Het
Thsd7a T C 6: 12,348,193 (GRCm38) probably benign Het
Tm9sf4 C T 2: 153,187,650 (GRCm38) T173M probably benign Het
Tmtc2 T C 10: 105,271,526 (GRCm38) T709A probably benign Het
Zfp385b T C 2: 77,450,303 (GRCm38) E97G probably damaging Het
Zim1 A T 7: 6,682,874 (GRCm38) probably null Het
Other mutations in Olfr1231
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01288:Olfr1231 APN 2 89,303,472 (GRCm38) missense possibly damaging 0.90
IGL02189:Olfr1231 APN 2 89,303,297 (GRCm38) missense probably damaging 1.00
IGL02354:Olfr1231 APN 2 89,303,182 (GRCm38) missense probably benign 0.03
PIT4305001:Olfr1231 UTSW 2 89,303,383 (GRCm38) missense probably benign 0.05
R0973:Olfr1231 UTSW 2 89,303,184 (GRCm38) missense probably damaging 1.00
R0973:Olfr1231 UTSW 2 89,303,184 (GRCm38) missense probably damaging 1.00
R0974:Olfr1231 UTSW 2 89,303,184 (GRCm38) missense probably damaging 1.00
R2006:Olfr1231 UTSW 2 89,302,816 (GRCm38) missense possibly damaging 0.60
R3150:Olfr1231 UTSW 2 89,303,218 (GRCm38) missense possibly damaging 0.82
R3177:Olfr1231 UTSW 2 89,303,218 (GRCm38) missense possibly damaging 0.82
R3277:Olfr1231 UTSW 2 89,303,218 (GRCm38) missense possibly damaging 0.82
R3409:Olfr1231 UTSW 2 89,303,373 (GRCm38) missense probably benign
R4208:Olfr1231 UTSW 2 89,302,926 (GRCm38) missense probably damaging 1.00
R4412:Olfr1231 UTSW 2 89,303,340 (GRCm38) missense probably benign 0.00
R4693:Olfr1231 UTSW 2 89,303,277 (GRCm38) missense probably benign 0.07
R4697:Olfr1231 UTSW 2 89,302,903 (GRCm38) missense probably damaging 1.00
R4697:Olfr1231 UTSW 2 89,302,902 (GRCm38) missense possibly damaging 0.90
R5411:Olfr1231 UTSW 2 89,303,576 (GRCm38) missense probably benign
R5992:Olfr1231 UTSW 2 89,303,359 (GRCm38) missense possibly damaging 0.50
R6894:Olfr1231 UTSW 2 89,303,493 (GRCm38) missense probably damaging 1.00
R8017:Olfr1231 UTSW 2 89,303,251 (GRCm38) missense possibly damaging 0.94
R8019:Olfr1231 UTSW 2 89,303,251 (GRCm38) missense possibly damaging 0.94
R9274:Olfr1231 UTSW 2 89,303,169 (GRCm38) missense probably damaging 0.98
R9457:Olfr1231 UTSW 2 89,302,731 (GRCm38) missense probably damaging 1.00
X0064:Olfr1231 UTSW 2 89,302,902 (GRCm38) missense possibly damaging 0.72
X0067:Olfr1231 UTSW 2 89,303,154 (GRCm38) missense possibly damaging 0.91
Posted On 2015-04-16