Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02361:Zim1'

290511

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zim1

Ensembl Gene

ENSMUSG00000002266

Gene Name

zinc finger, imprinted 1

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.055) question?

Stock #

IGL02361

Quality Score

Status

Chromosome

Chromosomal Location

6671269-6696450 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

A to T at 6682874 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000145453 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000002336] [ENSMUST00000122432] [ENSMUST00000203908]

AlphaFold

Q8C393

Predicted Effect

probably null
Transcript: ENSMUST00000002336

SMART Domains

Protein: ENSMUSP00000002336
Gene: ENSMUSG00000002266

Domain	Start	End	E-Value	Type
KRAB	50	110	5.78e-29	SMART
low complexity region	189	203	N/A	INTRINSIC
low complexity region	215	234	N/A	INTRINSIC
ZnF_C2H2	269	291	5.59e-4	SMART
ZnF_C2H2	297	319	2.05e-2	SMART
ZnF_C2H2	325	347	1.4e-4	SMART
ZnF_C2H2	353	375	8.6e-5	SMART
ZnF_C2H2	381	403	8.47e-4	SMART
ZnF_C2H2	409	431	2.71e-2	SMART
ZnF_C2H2	437	459	6.88e-4	SMART
ZnF_C2H2	465	487	6.32e-3	SMART
ZnF_C2H2	493	515	1.56e-2	SMART
ZnF_C2H2	521	543	3.95e-4	SMART
ZnF_C2H2	549	571	7.49e0	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000122432

SMART Domains

Protein: ENSMUSP00000113585
Gene: ENSMUSG00000002266

Domain	Start	End	E-Value	Type
KRAB	50	110	5.78e-29	SMART
low complexity region	189	203	N/A	INTRINSIC
low complexity region	215	234	N/A	INTRINSIC
ZnF_C2H2	269	291	5.59e-4	SMART
ZnF_C2H2	297	319	2.05e-2	SMART
ZnF_C2H2	325	347	1.4e-4	SMART
ZnF_C2H2	353	375	8.6e-5	SMART
ZnF_C2H2	381	403	8.47e-4	SMART
ZnF_C2H2	409	431	2.71e-2	SMART
ZnF_C2H2	437	459	6.88e-4	SMART
ZnF_C2H2	465	487	6.32e-3	SMART
ZnF_C2H2	493	515	1.56e-2	SMART
ZnF_C2H2	521	543	3.95e-4	SMART
ZnF_C2H2	549	571	7.49e0	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000203908

SMART Domains

Protein: ENSMUSP00000145453
Gene: ENSMUSG00000002266

Domain	Start	End	E-Value	Type
KRAB	50	110	5.78e-29	SMART
low complexity region	189	203	N/A	INTRINSIC
low complexity region	215	234	N/A	INTRINSIC
ZnF_C2H2	269	291	5.59e-4	SMART
ZnF_C2H2	297	319	2.05e-2	SMART
ZnF_C2H2	325	347	1.4e-4	SMART
ZnF_C2H2	353	375	8.6e-5	SMART
ZnF_C2H2	381	403	8.47e-4	SMART
ZnF_C2H2	409	431	2.71e-2	SMART
ZnF_C2H2	437	459	6.88e-4	SMART
ZnF_C2H2	465	487	6.32e-3	SMART
ZnF_C2H2	493	515	1.56e-2	SMART
ZnF_C2H2	521	543	3.95e-4	SMART
ZnF_C2H2	549	571	7.49e0	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000213399

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aqp1	A	C	6: 55,345,513	L164F	possibly damaging	Het
Bfsp1	T	C	2: 143,831,987	E261G	probably damaging	Het
Brinp2	A	G	1: 158,247,178	C458R	probably damaging	Het
Cacng3	T	G	7: 122,671,946	M58R	possibly damaging	Het
Cfap43	A	T	19: 47,897,413	C254*	probably null	Het
Cnga1	T	C	5: 72,616,718		probably null	Het
Dis3	A	T	14: 99,079,712	Y765*	probably null	Het
Dpep1	T	A	8: 123,200,218	S260R	probably benign	Het
Elmod1	A	G	9: 53,931,558	L106P	probably damaging	Het
Fut10	A	G	8: 31,201,370	Y81C	probably damaging	Het
Fzd10	T	A	5: 128,601,868	D217E	possibly damaging	Het
Gap43	T	C	16: 42,340,508		probably benign	Het
Gigyf1	T	C	5: 137,519,727		probably benign	Het
Gm1840	T	C	8: 5,640,896		noncoding transcript	Het
Gpc5	C	T	14: 115,133,287	R175*	probably null	Het
Kcna1	C	A	6: 126,642,906	Q150H	probably damaging	Het
Lama5	A	T	2: 180,193,884	C1225*	probably null	Het
Lrrc25	A	T	8: 70,617,827	D86V	probably benign	Het
Madd	A	T	2: 91,162,198	V1043E	probably benign	Het
Mov10	A	T	3: 104,804,121		probably benign	Het
Mzb1	T	A	18: 35,649,197	H46L	possibly damaging	Het
Nek10	A	T	14: 14,843,856	Q193L	probably damaging	Het
Nos3	A	T	5: 24,367,623	I187F	probably damaging	Het
Olfr1231	T	A	2: 89,303,182	M137L	probably benign	Het
Olfr473	T	A	7: 107,934,277	Y252*	probably null	Het
Olfr822	A	G	10: 130,075,274	Y288C	probably damaging	Het
Pgap1	T	C	1: 54,512,816	T486A	probably benign	Het
Prdm9	C	T	17: 15,562,847	V58M	probably damaging	Het
Prkd2	A	G	7: 16,847,658	Y146C	probably damaging	Het
Psmd9	G	T	5: 123,248,316	R175I	probably damaging	Het
Pxdn	A	G	12: 29,999,189	D618G	probably damaging	Het
Rgs6	A	T	12: 82,618,619		probably benign	Het
Rrm2	G	T	12: 24,711,439		probably benign	Het
Shank3	T	C	15: 89,504,333	V376A	probably damaging	Het
Slc5a10	A	G	11: 61,719,840		probably null	Het
Slfn3	A	T	11: 83,213,242	Q313L	possibly damaging	Het
Sptbn1	A	T	11: 30,110,783	F2062L	probably damaging	Het
Tbc1d10a	T	C	11: 4,215,047	V500A	probably benign	Het
Tcea1	T	C	1: 4,896,347		probably benign	Het
Thsd7a	T	C	6: 12,348,193		probably benign	Het
Tm9sf4	C	T	2: 153,187,650	T173M	probably benign	Het
Tmtc2	T	C	10: 105,271,526	T709A	probably benign	Het
Zfp385b	T	C	2: 77,450,303	E97G	probably damaging	Het

Other mutations in Zim1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00985:Zim1	APN	7	6682760	missense	possibly damaging	0.95
IGL01921:Zim1	APN	7	6682185	splice site	probably benign
IGL02116:Zim1	APN	7	6678254	missense	probably benign	0.00
IGL02252:Zim1	APN	7	6688628	missense	unknown
IGL02354:Zim1	APN	7	6682874	splice site	probably null
IGL03025:Zim1	APN	7	6682059	missense	probably benign	0.00
R0003:Zim1	UTSW	7	6676948	missense	probably benign	0.01
R1347:Zim1	UTSW	7	6677431	missense	probably damaging	1.00
R1347:Zim1	UTSW	7	6677431	missense	probably damaging	1.00
R1483:Zim1	UTSW	7	6682125	missense	probably benign	0.00
R2106:Zim1	UTSW	7	6678074	missense	probably benign	0.02
R2315:Zim1	UTSW	7	6677068	missense	possibly damaging	0.86
R2508:Zim1	UTSW	7	6677430	small insertion	probably benign
R2508:Zim1	UTSW	7	6677431	small insertion	probably benign
R3706:Zim1	UTSW	7	6677291	missense	probably damaging	0.97
R3975:Zim1	UTSW	7	6677130	missense	probably damaging	1.00
R5524:Zim1	UTSW	7	6677321	missense	probably benign	0.34
R5557:Zim1	UTSW	7	6677711	missense	probably damaging	1.00
R5843:Zim1	UTSW	7	6677698	missense	possibly damaging	0.59
R5844:Zim1	UTSW	7	6678116	missense	probably benign	0.21
R5882:Zim1	UTSW	7	6682738	critical splice donor site	probably null
R6828:Zim1	UTSW	7	6677689	missense	probably damaging	1.00
R6953:Zim1	UTSW	7	6687707	missense	unknown
R7080:Zim1	UTSW	7	6677306	missense	possibly damaging	0.92
R7148:Zim1	UTSW	7	6678221	missense	possibly damaging	0.91
R7199:Zim1	UTSW	7	6677873	nonsense	probably null
R7332:Zim1	UTSW	7	6677353	missense	probably damaging	1.00
R7462:Zim1	UTSW	7	6677812	missense	probably damaging	1.00
R8350:Zim1	UTSW	7	6682065	missense	probably damaging	0.99
R9480:Zim1	UTSW	7	6678051	missense	probably benign	0.20
R9510:Zim1	UTSW	7	6687740	nonsense	probably null
R9761:Zim1	UTSW	7	6677772	missense	probably damaging	1.00
Z1088:Zim1	UTSW	7	6677659	missense	possibly damaging	0.66

Posted On

2015-04-16