Incidental Mutation 'IGL02362:Cyp2c67'
ID 290518
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cyp2c67
Ensembl Gene ENSMUSG00000062624
Gene Name cytochrome P450, family 2, subfamily c, polypeptide 67
Synonyms C730004C24Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.090) question?
Stock # IGL02362
Quality Score
Status
Chromosome 19
Chromosomal Location 39597288-39637497 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to A at 39605826 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 357 (R357*)
Ref Sequence ENSEMBL: ENSMUSP00000065796 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000067328]
AlphaFold Q569X9
Predicted Effect probably null
Transcript: ENSMUST00000067328
AA Change: R357*
SMART Domains Protein: ENSMUSP00000065796
Gene: ENSMUSG00000062624
AA Change: R357*

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
Pfam:p450 30 487 8.5e-150 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam3 C A 8: 25,187,207 (GRCm39) C428F probably damaging Het
Alas1 T C 9: 106,113,838 (GRCm39) Y469C probably damaging Het
Asxl1 C T 2: 153,243,706 (GRCm39) L1419F probably benign Het
Bcan C T 3: 87,901,449 (GRCm39) D418N possibly damaging Het
Cdc42bpg A G 19: 6,360,839 (GRCm39) D199G possibly damaging Het
Chst15 T C 7: 131,868,401 (GRCm39) N340D probably benign Het
Col12a1 T G 9: 79,537,993 (GRCm39) probably benign Het
Ears2 T C 7: 121,643,773 (GRCm39) D395G probably benign Het
Fam227a A T 15: 79,528,139 (GRCm39) probably benign Het
Fap A G 2: 62,403,842 (GRCm39) V11A probably benign Het
Ganc A G 2: 120,264,238 (GRCm39) D397G probably damaging Het
Gjb6 C A 14: 57,361,752 (GRCm39) G170C possibly damaging Het
Gria2 A T 3: 80,614,244 (GRCm39) W599R probably damaging Het
Gvin-ps5 T C 7: 105,929,480 (GRCm39) noncoding transcript Het
Ighv1-64 A G 12: 115,471,236 (GRCm39) S94P probably benign Het
Kifc3 C T 8: 95,836,507 (GRCm39) A85T probably damaging Het
Lifr G A 15: 7,194,174 (GRCm39) probably null Het
Lonp2 T G 8: 87,350,874 (GRCm39) S21R probably benign Het
Nxpe3 A G 16: 55,710,949 (GRCm39) V30A probably benign Het
Olfml1 T C 7: 107,167,010 (GRCm39) V13A probably benign Het
Or10w1 T C 19: 13,632,597 (GRCm39) V268A probably benign Het
Or1af1 A G 2: 37,109,681 (GRCm39) Y60C probably damaging Het
Pcnt G A 10: 76,210,996 (GRCm39) Q2376* probably null Het
Pglyrp2 A G 17: 32,635,996 (GRCm39) L380P probably damaging Het
Plin3 A G 17: 56,593,636 (GRCm39) V26A probably benign Het
Potefam1 T C 2: 111,041,996 (GRCm39) probably benign Het
Pramel25 A G 4: 143,519,580 (GRCm39) S114G probably damaging Het
Rims1 A G 1: 22,522,288 (GRCm39) I470T probably damaging Het
Rora T C 9: 69,281,374 (GRCm39) Y329H probably damaging Het
Scnn1b G A 7: 121,516,770 (GRCm39) R503H probably damaging Het
Sec14l1 A G 11: 117,035,675 (GRCm39) D237G possibly damaging Het
Selplg A G 5: 113,957,467 (GRCm39) S280P probably benign Het
Serpina12 A G 12: 104,004,140 (GRCm39) L164P probably benign Het
Sik2 C T 9: 50,828,903 (GRCm39) W176* probably null Het
Slc2a1 T C 4: 118,993,612 (GRCm39) F483S possibly damaging Het
Speg A G 1: 75,400,559 (GRCm39) D2573G possibly damaging Het
Stil C T 4: 114,867,308 (GRCm39) S239L probably damaging Het
Tmem94 C A 11: 115,685,571 (GRCm39) S941R probably damaging Het
Tnfrsf11b T A 15: 54,115,778 (GRCm39) D273V probably damaging Het
Tns2 A G 15: 102,020,725 (GRCm39) T864A probably benign Het
Zfpm2 A G 15: 40,962,890 (GRCm39) H184R probably damaging Het
Other mutations in Cyp2c67
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00955:Cyp2c67 APN 19 39,631,829 (GRCm39) missense possibly damaging 0.95
IGL01025:Cyp2c67 APN 19 39,628,376 (GRCm39) nonsense probably null
IGL01363:Cyp2c67 APN 19 39,628,411 (GRCm39) missense probably damaging 0.99
IGL01819:Cyp2c67 APN 19 39,604,165 (GRCm39) missense probably damaging 0.98
IGL01902:Cyp2c67 APN 19 39,637,470 (GRCm39) missense probably damaging 1.00
IGL02172:Cyp2c67 APN 19 39,637,446 (GRCm39) missense possibly damaging 0.76
IGL02351:Cyp2c67 APN 19 39,605,861 (GRCm39) missense probably damaging 1.00
IGL02355:Cyp2c67 APN 19 39,605,826 (GRCm39) nonsense probably null
IGL02355:Cyp2c67 APN 19 39,631,849 (GRCm39) missense probably benign 0.34
IGL02358:Cyp2c67 APN 19 39,605,861 (GRCm39) missense probably damaging 1.00
IGL02362:Cyp2c67 APN 19 39,631,849 (GRCm39) missense probably benign 0.34
IGL02388:Cyp2c67 APN 19 39,631,799 (GRCm39) missense probably benign 0.20
IGL03106:Cyp2c67 APN 19 39,632,119 (GRCm39) missense probably benign 0.27
IGL03219:Cyp2c67 APN 19 39,631,738 (GRCm39) missense possibly damaging 0.54
IGL03326:Cyp2c67 APN 19 39,631,713 (GRCm39) critical splice donor site probably null
IGL03349:Cyp2c67 APN 19 39,632,128 (GRCm39) missense probably damaging 1.00
IGL03356:Cyp2c67 APN 19 39,628,405 (GRCm39) missense probably damaging 1.00
IGL03052:Cyp2c67 UTSW 19 39,637,329 (GRCm39) missense possibly damaging 0.88
R0585:Cyp2c67 UTSW 19 39,627,138 (GRCm39) missense possibly damaging 0.59
R0975:Cyp2c67 UTSW 19 39,597,622 (GRCm39) missense possibly damaging 0.49
R0976:Cyp2c67 UTSW 19 39,631,818 (GRCm39) missense probably damaging 1.00
R1252:Cyp2c67 UTSW 19 39,614,585 (GRCm39) missense possibly damaging 0.93
R1398:Cyp2c67 UTSW 19 39,627,069 (GRCm39) missense probably damaging 0.96
R1411:Cyp2c67 UTSW 19 39,627,035 (GRCm39) missense probably damaging 1.00
R1505:Cyp2c67 UTSW 19 39,637,408 (GRCm39) missense probably benign 0.00
R1543:Cyp2c67 UTSW 19 39,631,708 (GRCm39) splice site probably benign
R1613:Cyp2c67 UTSW 19 39,614,643 (GRCm39) missense probably benign 0.00
R1618:Cyp2c67 UTSW 19 39,631,708 (GRCm39) splice site probably benign
R1667:Cyp2c67 UTSW 19 39,632,034 (GRCm39) critical splice donor site probably null
R1852:Cyp2c67 UTSW 19 39,605,811 (GRCm39) missense probably benign 0.01
R2005:Cyp2c67 UTSW 19 39,631,789 (GRCm39) missense probably damaging 1.00
R2105:Cyp2c67 UTSW 19 39,614,681 (GRCm39) missense probably benign 0.24
R2181:Cyp2c67 UTSW 19 39,597,541 (GRCm39) missense possibly damaging 0.94
R3817:Cyp2c67 UTSW 19 39,627,127 (GRCm39) missense probably benign 0.00
R4669:Cyp2c67 UTSW 19 39,632,098 (GRCm39) missense probably benign 0.00
R4689:Cyp2c67 UTSW 19 39,627,032 (GRCm39) missense probably benign 0.00
R4756:Cyp2c67 UTSW 19 39,632,188 (GRCm39) missense probably benign 0.03
R4823:Cyp2c67 UTSW 19 39,604,168 (GRCm39) missense probably benign 0.13
R5152:Cyp2c67 UTSW 19 39,627,132 (GRCm39) missense probably benign 0.00
R5345:Cyp2c67 UTSW 19 39,614,676 (GRCm39) missense probably benign 0.01
R5580:Cyp2c67 UTSW 19 39,604,094 (GRCm39) missense probably damaging 0.99
R5644:Cyp2c67 UTSW 19 39,604,138 (GRCm39) missense possibly damaging 0.84
R6116:Cyp2c67 UTSW 19 39,605,879 (GRCm39) missense probably damaging 1.00
R6516:Cyp2c67 UTSW 19 39,605,873 (GRCm39) missense probably damaging 1.00
R6550:Cyp2c67 UTSW 19 39,605,854 (GRCm39) nonsense probably null
R6939:Cyp2c67 UTSW 19 39,631,778 (GRCm39) missense possibly damaging 0.68
R6995:Cyp2c67 UTSW 19 39,604,123 (GRCm39) missense probably damaging 0.96
R7028:Cyp2c67 UTSW 19 39,628,341 (GRCm39) missense possibly damaging 0.68
R7144:Cyp2c67 UTSW 19 39,604,138 (GRCm39) missense probably benign 0.00
R7242:Cyp2c67 UTSW 19 39,605,783 (GRCm39) missense probably benign 0.30
R7335:Cyp2c67 UTSW 19 39,628,451 (GRCm39) nonsense probably null
R7337:Cyp2c67 UTSW 19 39,597,708 (GRCm39) splice site probably null
R7474:Cyp2c67 UTSW 19 39,605,876 (GRCm39) missense probably null 0.05
R7642:Cyp2c67 UTSW 19 39,604,084 (GRCm39) missense probably damaging 0.97
R7870:Cyp2c67 UTSW 19 39,597,669 (GRCm39) missense probably damaging 1.00
R8152:Cyp2c67 UTSW 19 39,628,452 (GRCm39) missense probably benign 0.21
R8367:Cyp2c67 UTSW 19 39,627,118 (GRCm39) missense probably benign 0.01
R8717:Cyp2c67 UTSW 19 39,627,155 (GRCm39) missense probably benign 0.05
R8728:Cyp2c67 UTSW 19 39,614,605 (GRCm39) missense probably damaging 1.00
R9275:Cyp2c67 UTSW 19 39,597,699 (GRCm39) missense probably damaging 1.00
R9278:Cyp2c67 UTSW 19 39,597,699 (GRCm39) missense probably damaging 1.00
R9376:Cyp2c67 UTSW 19 39,627,178 (GRCm39) missense probably damaging 1.00
Z1177:Cyp2c67 UTSW 19 39,632,123 (GRCm39) missense possibly damaging 0.89
Posted On 2015-04-16