Incidental Mutation 'IGL02365:Olfr470'
ID290670
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr470
Ensembl Gene ENSMUSG00000109542
Gene Nameolfactory receptor 470
SynonymsMOR204-22, GA_x6K02T2PBJ9-10175273-10174329
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.204) question?
Stock #IGL02365
Quality Score
Status
Chromosome7
Chromosomal Location107842905-107847490 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 107844912 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Tyrosine at position 274 (N274Y)
Ref Sequence ENSEMBL: ENSMUSP00000151543 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073059] [ENSMUST00000220193]
Predicted Effect probably damaging
Transcript: ENSMUST00000073059
AA Change: N274Y

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000072810
Gene: ENSMUSG00000109542
AA Change: N274Y

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 2e-56 PFAM
Pfam:7tm_1 44 293 2e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207145
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219309
Predicted Effect probably damaging
Transcript: ENSMUST00000220193
AA Change: N274Y

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933400A11Rik T C X: 169,776,530 N272D probably benign Het
Acyp2 A T 11: 30,649,318 V21E probably damaging Het
Adgrl3 A G 5: 81,512,581 D331G probably damaging Het
Arfgef1 A T 1: 10,199,883 I347N probably benign Het
Bfsp1 T G 2: 143,826,736 E647A probably damaging Het
Bhmt A T 13: 93,617,638 N354K probably benign Het
Brinp3 A T 1: 146,901,122 T436S probably benign Het
Cog7 C A 7: 121,977,736 M66I possibly damaging Het
Csf2rb2 A T 15: 78,287,060 M333K possibly damaging Het
Cyp2u1 A G 3: 131,298,229 V214A probably damaging Het
Dcaf5 A T 12: 80,398,773 H177Q probably benign Het
Dchs1 T C 7: 105,755,188 T2716A probably benign Het
Dsc1 T C 18: 20,108,816 Q156R probably damaging Het
Dspp G T 5: 104,176,061 G357W probably damaging Het
Efr3b C T 12: 3,983,391 V139I probably benign Het
Fto T G 8: 91,468,375 S265R probably damaging Het
Gphb5 A G 12: 75,415,817 probably benign Het
Iars T C 13: 49,691,499 V162A probably benign Het
Klk13 A C 7: 43,723,866 K107T possibly damaging Het
Kpna7 T A 5: 144,985,733 D507V possibly damaging Het
Lamb1 A T 12: 31,318,345 E1158V probably damaging Het
Lonp2 A T 8: 86,716,365 D818V possibly damaging Het
Med15 A G 16: 17,671,606 probably benign Het
Olfr810 T C 10: 129,791,535 D18G possibly damaging Het
Olfr965 A T 9: 39,719,674 Y149F possibly damaging Het
Olfr965 G A 9: 39,720,100 S291N probably damaging Het
Plpbp A G 8: 27,045,924 I82V probably benign Het
Ptprcap A G 19: 4,156,268 I117V probably benign Het
Rhox12 T A X: 38,107,881 D88V possibly damaging Het
Rnpc3 A G 3: 113,608,399 S500P probably damaging Het
Sdhd A T 9: 50,598,825 Y84N possibly damaging Het
Sema6d G A 2: 124,656,868 V233I probably benign Het
Vegfb A T 19: 6,985,487 I140N probably benign Het
Vldlr A G 19: 27,245,625 Y732C probably damaging Het
Vmn2r17 T A 5: 109,453,309 F824L probably damaging Het
Xdh A T 17: 73,943,890 N22K probably benign Het
Zc3h11a A C 1: 133,637,413 N249K probably benign Het
Zwilch T A 9: 64,160,924 D203V probably damaging Het
Other mutations in Olfr470
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02034:Olfr470 APN 7 107845178 missense probably benign 0.00
IGL02349:Olfr470 APN 7 107845605 missense probably benign 0.03
R0070:Olfr470 UTSW 7 107844917 missense probably damaging 0.99
R0540:Olfr470 UTSW 7 107845569 missense probably damaging 0.98
R0607:Olfr470 UTSW 7 107845569 missense probably damaging 0.98
R0624:Olfr470 UTSW 7 107845116 missense possibly damaging 0.87
R1983:Olfr470 UTSW 7 107845412 missense probably benign 0.36
R2420:Olfr470 UTSW 7 107844818 missense probably benign 0.03
R2441:Olfr470 UTSW 7 107844978 missense probably benign 0.10
R4395:Olfr470 UTSW 7 107845262 missense probably damaging 1.00
R4734:Olfr470 UTSW 7 107845428 missense probably benign 0.00
R4779:Olfr470 UTSW 7 107845548 missense possibly damaging 0.96
R5874:Olfr470 UTSW 7 107845170 missense probably benign
R6598:Olfr470 UTSW 7 107845263 missense probably benign 0.06
R6807:Olfr470 UTSW 7 107845590 missense possibly damaging 0.67
R6820:Olfr470 UTSW 7 107845091 missense probably benign 0.01
R7305:Olfr470 UTSW 7 107845365 missense probably damaging 1.00
R7413:Olfr470 UTSW 7 107845514 missense probably damaging 1.00
R7954:Olfr470 UTSW 7 107844912 missense probably benign 0.01
R8215:Olfr470 UTSW 7 107844917 missense probably damaging 0.99
R8255:Olfr470 UTSW 7 107845161 missense probably damaging 1.00
R8384:Olfr470 UTSW 7 107845258 missense possibly damaging 0.94
Posted On2015-04-16