Incidental Mutation 'IGL02365:Olfr965'
ID 290672
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr965
Ensembl Gene ENSMUSG00000095839
Gene Name olfactory receptor 965
Synonyms GA_x6K02T2PVTD-33416730-33417668, MOR171-28
Accession Numbers
Essential gene? Probably non essential (E-score: 0.099) question?
Stock # IGL02365
Quality Score
Chromosome 9
Chromosomal Location 39711353-39720614 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to A at 39720100 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Serine to Asparagine at position 291 (S291N)
Ref Sequence ENSEMBL: ENSMUSP00000150401 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069342] [ENSMUST00000213335] [ENSMUST00000215164]
AlphaFold Q7TRA7
Predicted Effect probably damaging
Transcript: ENSMUST00000069342
AA Change: S291N

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000069696
Gene: ENSMUSG00000095839
AA Change: S291N

Pfam:7tm_4 31 308 1.4e-47 PFAM
Pfam:7tm_1 41 290 4.2e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213335
AA Change: S291N

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214875
Predicted Effect probably damaging
Transcript: ENSMUST00000215164
AA Change: S291N

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933400A11Rik T C X: 169,776,530 (GRCm38) N272D probably benign Het
Acyp2 A T 11: 30,649,318 (GRCm38) V21E probably damaging Het
Adgrl3 A G 5: 81,512,581 (GRCm38) D331G probably damaging Het
Arfgef1 A T 1: 10,199,883 (GRCm38) I347N probably benign Het
Bfsp1 T G 2: 143,826,736 (GRCm38) E647A probably damaging Het
Bhmt A T 13: 93,617,638 (GRCm38) N354K probably benign Het
Brinp3 A T 1: 146,901,122 (GRCm38) T436S probably benign Het
Cog7 C A 7: 121,977,736 (GRCm38) M66I possibly damaging Het
Csf2rb2 A T 15: 78,287,060 (GRCm38) M333K possibly damaging Het
Cyp2u1 A G 3: 131,298,229 (GRCm38) V214A probably damaging Het
Dcaf5 A T 12: 80,398,773 (GRCm38) H177Q probably benign Het
Dchs1 T C 7: 105,755,188 (GRCm38) T2716A probably benign Het
Dsc1 T C 18: 20,108,816 (GRCm38) Q156R probably damaging Het
Dspp G T 5: 104,176,061 (GRCm38) G357W probably damaging Het
Efr3b C T 12: 3,983,391 (GRCm38) V139I probably benign Het
Fto T G 8: 91,468,375 (GRCm38) S265R probably damaging Het
Gphb5 A G 12: 75,415,817 (GRCm38) probably benign Het
Iars T C 13: 49,691,499 (GRCm38) V162A probably benign Het
Klk13 A C 7: 43,723,866 (GRCm38) K107T possibly damaging Het
Kpna7 T A 5: 144,985,733 (GRCm38) D507V possibly damaging Het
Lamb1 A T 12: 31,318,345 (GRCm38) E1158V probably damaging Het
Lonp2 A T 8: 86,716,365 (GRCm38) D818V possibly damaging Het
Med15 A G 16: 17,671,606 (GRCm38) probably benign Het
Olfr470 T A 7: 107,844,912 (GRCm38) N274Y probably damaging Het
Olfr810 T C 10: 129,791,535 (GRCm38) D18G possibly damaging Het
Plpbp A G 8: 27,045,924 (GRCm38) I82V probably benign Het
Ptprcap A G 19: 4,156,268 (GRCm38) I117V probably benign Het
Rhox12 T A X: 38,107,881 (GRCm38) D88V possibly damaging Het
Rnpc3 A G 3: 113,608,399 (GRCm38) S500P probably damaging Het
Sdhd A T 9: 50,598,825 (GRCm38) Y84N possibly damaging Het
Sema6d G A 2: 124,656,868 (GRCm38) V233I probably benign Het
Vegfb A T 19: 6,985,487 (GRCm38) I140N probably benign Het
Vldlr A G 19: 27,245,625 (GRCm38) Y732C probably damaging Het
Vmn2r17 T A 5: 109,453,309 (GRCm38) F824L probably damaging Het
Xdh A T 17: 73,943,890 (GRCm38) N22K probably benign Het
Zc3h11a A C 1: 133,637,413 (GRCm38) N249K probably benign Het
Zwilch T A 9: 64,160,924 (GRCm38) D203V probably damaging Het
Other mutations in Olfr965
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01705:Olfr965 APN 9 39,719,581 (GRCm38) missense possibly damaging 0.95
IGL02365:Olfr965 APN 9 39,719,674 (GRCm38) missense possibly damaging 0.60
IGL03062:Olfr965 APN 9 39,720,035 (GRCm38) missense probably benign 0.26
IGL03330:Olfr965 APN 9 39,719,488 (GRCm38) missense probably benign 0.08
R0011:Olfr965 UTSW 9 39,719,627 (GRCm38) missense probably benign 0.26
R0462:Olfr965 UTSW 9 39,719,410 (GRCm38) missense probably benign 0.01
R1505:Olfr965 UTSW 9 39,719,478 (GRCm38) missense probably damaging 1.00
R1995:Olfr965 UTSW 9 39,719,413 (GRCm38) missense probably damaging 1.00
R2049:Olfr965 UTSW 9 39,720,115 (GRCm38) missense probably damaging 1.00
R2110:Olfr965 UTSW 9 39,719,722 (GRCm38) missense probably benign 0.30
R3817:Olfr965 UTSW 9 39,720,108 (GRCm38) missense possibly damaging 0.95
R4152:Olfr965 UTSW 9 39,720,000 (GRCm38) missense probably benign 0.10
R4153:Olfr965 UTSW 9 39,720,000 (GRCm38) missense probably benign 0.10
R4351:Olfr965 UTSW 9 39,719,569 (GRCm38) missense probably damaging 0.99
R4377:Olfr965 UTSW 9 39,719,807 (GRCm38) missense probably benign 0.04
R4667:Olfr965 UTSW 9 39,719,709 (GRCm38) missense probably benign 0.09
R5526:Olfr965 UTSW 9 39,719,596 (GRCm38) missense possibly damaging 0.95
R5816:Olfr965 UTSW 9 39,719,230 (GRCm38) start codon destroyed probably null 1.00
R7113:Olfr965 UTSW 9 39,719,677 (GRCm38) missense probably benign
R7336:Olfr965 UTSW 9 39,719,610 (GRCm38) missense probably benign 0.28
R8153:Olfr965 UTSW 9 39,719,658 (GRCm38) missense possibly damaging 0.68
R8291:Olfr965 UTSW 9 39,719,545 (GRCm38) missense probably benign 0.00
R8779:Olfr965 UTSW 9 39,719,340 (GRCm38) missense probably damaging 0.99
R9617:Olfr965 UTSW 9 39,719,382 (GRCm38) missense possibly damaging 0.80
R9631:Olfr965 UTSW 9 39,719,865 (GRCm38) missense possibly damaging 0.78
Posted On 2015-04-16