Incidental Mutation 'IGL02367:Olfml2a'
ID290788
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfml2a
Ensembl Gene ENSMUSG00000046618
Gene Nameolfactomedin-like 2A
Synonymsphotomedin-1, 4932431K08Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.113) question?
Stock #IGL02367
Quality Score
Status
Chromosome2
Chromosomal Location38931978-38963753 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 38954668 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 379 (T379A)
Ref Sequence ENSEMBL: ENSMUSP00000058761 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057279]
Predicted Effect probably benign
Transcript: ENSMUST00000057279
AA Change: T379A

PolyPhen 2 Score 0.146 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000058761
Gene: ENSMUSG00000046618
AA Change: T379A

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
internal_repeat_1 39 66 2.55e-7 PROSPERO
internal_repeat_1 78 105 2.55e-7 PROSPERO
coiled coil region 168 189 N/A INTRINSIC
low complexity region 212 228 N/A INTRINSIC
low complexity region 252 271 N/A INTRINSIC
low complexity region 302 320 N/A INTRINSIC
low complexity region 367 407 N/A INTRINSIC
OLF 426 681 8.73e-69 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930407I10Rik T C 15: 82,065,547 L1215P probably benign Het
Angptl7 T C 4: 148,500,144 N49S possibly damaging Het
Asns A G 6: 7,685,411 probably benign Het
Atr T A 9: 95,899,141 Y1419* probably null Het
Bptf A T 11: 107,073,352 I1672N probably benign Het
Chd1 A G 17: 17,390,053 T490A probably damaging Het
Cyfip2 A T 11: 46,276,905 C223* probably null Het
Ddr1 G A 17: 35,683,480 A801V probably damaging Het
Dnah12 T C 14: 26,709,161 V308A probably benign Het
Dync2h1 A G 9: 7,158,926 V703A probably damaging Het
Fgd3 A G 13: 49,287,326 F210L probably damaging Het
Gm10020 T C 15: 52,477,972 noncoding transcript Het
Gm6526 T G 14: 43,750,805 V171G probably damaging Het
Grin3a A G 4: 49,702,805 Y894H probably damaging Het
Grm3 C A 5: 9,511,660 C730F probably damaging Het
Habp4 C A 13: 64,174,091 P181T probably damaging Het
Hdac4 A G 1: 91,958,449 probably benign Het
Ints5 A G 19: 8,895,595 D306G probably benign Het
Mb21d1 G A 9: 78,434,385 T370I probably benign Het
Mid2 T A X: 140,736,496 I273N probably damaging Het
Ndufs2 A T 1: 171,239,365 Y114* probably null Het
Neu4 G T 1: 94,024,491 R194L probably damaging Het
Ntng1 A T 3: 110,135,513 probably null Het
Nub1 A G 5: 24,689,394 M1V probably null Het
Olfr311 A T 11: 58,841,512 I133F probably benign Het
Pex3 G T 10: 13,524,899 Q303K probably benign Het
Pmp2 A T 3: 10,182,500 I43N probably damaging Het
Pnliprp1 T A 19: 58,738,169 D319E probably benign Het
Rap1gap2 A T 11: 74,397,355 probably null Het
Rwdd3 A G 3: 121,159,030 V104A probably damaging Het
Sbf1 A T 15: 89,307,572 V157E probably damaging Het
Slc4a11 T A 2: 130,684,959 I750F probably damaging Het
Tcea1 G A 1: 4,878,133 probably null Het
Ush2a A T 1: 188,784,746 M3218L probably benign Het
Utp20 G A 10: 88,771,853 probably benign Het
Zfp493 T A 13: 67,786,970 Y347* probably null Het
Zswim6 T C 13: 107,744,102 noncoding transcript Het
Other mutations in Olfml2a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01098:Olfml2a APN 2 38947214 critical splice acceptor site probably null
IGL03140:Olfml2a APN 2 38947291 missense probably damaging 1.00
R0559:Olfml2a UTSW 2 38959820 missense probably damaging 1.00
R0781:Olfml2a UTSW 2 38959753 missense probably damaging 0.99
R1110:Olfml2a UTSW 2 38959753 missense probably damaging 0.99
R1187:Olfml2a UTSW 2 38959813 missense probably damaging 1.00
R1626:Olfml2a UTSW 2 38951263 missense probably damaging 1.00
R1634:Olfml2a UTSW 2 38960219 missense probably benign 0.03
R2127:Olfml2a UTSW 2 38941687 missense probably damaging 1.00
R2987:Olfml2a UTSW 2 38947294 missense probably damaging 0.97
R4428:Olfml2a UTSW 2 38941743 missense probably damaging 0.96
R4564:Olfml2a UTSW 2 38960294 missense probably benign 0.40
R4609:Olfml2a UTSW 2 38957721 missense probably damaging 0.98
R4667:Olfml2a UTSW 2 38949010 missense probably damaging 0.99
R4703:Olfml2a UTSW 2 38951238 missense probably damaging 1.00
R4827:Olfml2a UTSW 2 38960021 missense probably damaging 1.00
R5588:Olfml2a UTSW 2 38960035 missense probably damaging 1.00
R5879:Olfml2a UTSW 2 38960230 missense probably damaging 1.00
R6063:Olfml2a UTSW 2 38951143 missense probably benign 0.03
R6484:Olfml2a UTSW 2 38959768 missense probably damaging 1.00
R6788:Olfml2a UTSW 2 38960226 nonsense probably null
R7345:Olfml2a UTSW 2 38960127 missense probably damaging 1.00
R7474:Olfml2a UTSW 2 38960261 missense probably damaging 0.98
R8073:Olfml2a UTSW 2 38957754 missense probably damaging 1.00
Z1177:Olfml2a UTSW 2 38960284 missense possibly damaging 0.69
Posted On2015-04-16