Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02369:Prdm11'

290835

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Prdm11

Ensembl Gene

ENSMUSG00000075028

Gene Name

PR domain containing 11

Synonyms

Accession Numbers

Is this an essential gene?

Possibly non essential (E-score: 0.457) question?

Stock #

IGL02369

Quality Score

Status

Chromosome

Chromosomal Location

92965151-93046167 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 92975519 bp

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 362 (V362A)

Ref Sequence

ENSEMBL: ENSMUSP00000136795 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000111274] [ENSMUST00000178666]

Predicted Effect

probably benign
Transcript: ENSMUST00000111274
AA Change: V362A

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

SMART Domains

Protein: ENSMUSP00000106905
Gene: ENSMUSG00000075028
AA Change: V362A

Domain	Start	End	E-Value	Type
SET	115	232	5.16e-2	SMART
low complexity region	369	380	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000178666
AA Change: V362A

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

SMART Domains

Protein: ENSMUSP00000136795
Gene: ENSMUSG00000075028
AA Change: V362A

Domain	Start	End	E-Value	Type
SET	115	232	5.16e-2	SMART
low complexity region	369	380	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adck2	G	T	6: 39,574,744	L148F	probably damaging	Het
Arhgef10	G	A	8: 14,997,551	R1138H	probably damaging	Het
Arpp21	T	C	9: 112,119,198	T668A	probably benign	Het
Atp6v0b	T	A	4: 117,885,653	I79F	possibly damaging	Het
Atp8b5	A	T	4: 43,334,205	N324Y	probably benign	Het
Bach2	A	G	4: 32,579,975	I610M	possibly damaging	Het
Casr	G	T	16: 36,494,689	D929E	probably benign	Het
Cbln2	T	C	18: 86,713,354	S96P	probably damaging	Het
Cpxm1	T	C	2: 130,396,424	K73E	probably damaging	Het
Erap1	A	G	13: 74,666,526	Y457C	probably benign	Het
Etl4	T	C	2: 20,530,189	Y152H	probably damaging	Het
Fbxo18	A	T	2: 11,747,158	S910T	possibly damaging	Het
Gm10142	T	C	10: 77,716,113	S103P	probably benign	Het
Gm12886	A	G	4: 121,423,032	S16P	unknown	Het
Gpr146	T	C	5: 139,392,688	Y82H	probably benign	Het
Herc1	C	T	9: 66,492,011	Q4282*	probably null	Het
Htr2a	A	T	14: 74,706,282	E434V	probably benign	Het
Iqsec3	T	C	6: 121,412,934		probably benign	Het
Islr	A	C	9: 58,157,624	V200G	probably damaging	Het
Katnal1	T	C	5: 148,878,927	D400G	probably benign	Het
Lonrf2	A	G	1: 38,811,832		probably benign	Het
Lrp2	A	T	2: 69,464,636	L3446Q	probably damaging	Het
Med12l	G	A	3: 59,257,373	V1425I	probably benign	Het
Myh13	T	C	11: 67,360,274		probably benign	Het
Nutm2	T	G	13: 50,469,908	S214A	probably benign	Het
Olfr1451	T	C	19: 12,999,708	S241P	probably damaging	Het
Olfr433	T	A	1: 174,041,973	W8R	possibly damaging	Het
Olfr820	C	A	10: 130,017,556	A65E	possibly damaging	Het
Olfr93	A	G	17: 37,151,774	F66S	probably damaging	Het
Pax5	A	T	4: 44,691,919	M109K	probably damaging	Het
Pfkfb2	G	A	1: 130,700,835	R345W	probably damaging	Het
Pkd1l3	A	G	8: 109,616,345	D105G	unknown	Het
Prex2	T	C	1: 11,101,169		probably null	Het
Prl8a1	T	C	13: 27,576,941	T103A	possibly damaging	Het
Rgl1	T	C	1: 152,533,606	I493V	probably damaging	Het
Rimkla	A	G	4: 119,477,949	V79A	possibly damaging	Het
Ryr2	A	T	13: 11,619,496	S3791R	possibly damaging	Het
Sh3rf2	C	A	18: 42,156,157	S681*	probably null	Het
Stmnd1	T	A	13: 46,285,553	I87K	probably benign	Het
Tspan8	C	A	10: 115,839,877	F149L	probably benign	Het
Tspan8	A	C	10: 115,839,878	K150Q	probably benign	Het
Ttn	T	C	2: 76,942,376	E2425G	probably damaging	Het

Other mutations in Prdm11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01526:Prdm11	APN	2	93012757	missense	probably damaging	1.00
IGL02108:Prdm11	APN	2	92975703	missense	probably damaging	1.00
IGL02166:Prdm11	APN	2	93012863	missense	probably damaging	1.00
IGL02388:Prdm11	APN	2	92975612	missense	possibly damaging	0.90
IGL02606:Prdm11	APN	2	92975603	missense	probably benign	0.02
IGL02967:Prdm11	APN	2	93012889	missense	probably damaging	1.00
IGL03085:Prdm11	APN	2	92974959	missense	possibly damaging	0.86
IGL03125:Prdm11	APN	2	92980622	missense	probably benign	0.22
E0370:Prdm11	UTSW	2	92980579	missense	probably damaging	1.00
R0607:Prdm11	UTSW	2	93013785	missense	possibly damaging	0.85
R0964:Prdm11	UTSW	2	92989222	intron	probably benign
R4011:Prdm11	UTSW	2	93012830	missense	probably damaging	1.00
R4298:Prdm11	UTSW	2	92993383	missense	probably benign	0.44
R4951:Prdm11	UTSW	2	92980609	missense	probably damaging	1.00
R5150:Prdm11	UTSW	2	92975472	missense	probably damaging	1.00
R5320:Prdm11	UTSW	2	93012881	missense	probably benign	0.00
R5432:Prdm11	UTSW	2	92975813	missense	probably benign	0.00
R6442:Prdm11	UTSW	2	92975645	missense	probably benign	0.34
R6754:Prdm11	UTSW	2	93013792	missense	probably damaging	1.00
R7403:Prdm11	UTSW	2	92986691	missense	probably benign
R7480:Prdm11	UTSW	2	92975324	missense	probably benign	0.05
R7497:Prdm11	UTSW	2	93012707	missense	possibly damaging	0.93
R7633:Prdm11	UTSW	2	92980654	missense	probably damaging	1.00

Posted On

2015-04-16