Incidental Mutation 'IGL02369:Gpr146'
ID290849
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr146
Ensembl Gene ENSMUSG00000044197
Gene NameG protein-coupled receptor 146
SynonymsPGR8
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02369
Quality Score
Status
Chromosome5
Chromosomal Location139377697-139396415 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 139392688 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Histidine at position 82 (Y82H)
Ref Sequence ENSEMBL: ENSMUSP00000119464 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051293] [ENSMUST00000066052] [ENSMUST00000100514] [ENSMUST00000138631] [ENSMUST00000198474]
Predicted Effect probably benign
Transcript: ENSMUST00000051293
AA Change: Y82H

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000049707
Gene: ENSMUSG00000044197
AA Change: Y82H

DomainStartEndE-ValueType
low complexity region 21 36 N/A INTRINSIC
Pfam:7tm_1 43 294 2e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000066052
SMART Domains Protein: ENSMUSP00000069230
Gene: ENSMUSG00000053553

DomainStartEndE-ValueType
low complexity region 54 77 N/A INTRINSIC
Pfam:DUF2373 103 165 3e-26 PFAM
low complexity region 184 194 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000100514
AA Change: Y82H

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000098083
Gene: ENSMUSG00000044197
AA Change: Y82H

DomainStartEndE-ValueType
low complexity region 21 36 N/A INTRINSIC
Pfam:7tm_1 43 294 1.6e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000138631
AA Change: Y82H

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000119464
Gene: ENSMUSG00000044197
AA Change: Y82H

DomainStartEndE-ValueType
SCOP:d1l9ha_ 26 80 3e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196267
Predicted Effect probably benign
Transcript: ENSMUST00000198474
SMART Domains Protein: ENSMUSP00000142949
Gene: ENSMUSG00000053553

DomainStartEndE-ValueType
low complexity region 54 77 N/A INTRINSIC
Pfam:DUF2373 102 141 9e-12 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adck2 G T 6: 39,574,744 L148F probably damaging Het
Arhgef10 G A 8: 14,997,551 R1138H probably damaging Het
Arpp21 T C 9: 112,119,198 T668A probably benign Het
Atp6v0b T A 4: 117,885,653 I79F possibly damaging Het
Atp8b5 A T 4: 43,334,205 N324Y probably benign Het
Bach2 A G 4: 32,579,975 I610M possibly damaging Het
Casr G T 16: 36,494,689 D929E probably benign Het
Cbln2 T C 18: 86,713,354 S96P probably damaging Het
Cpxm1 T C 2: 130,396,424 K73E probably damaging Het
Erap1 A G 13: 74,666,526 Y457C probably benign Het
Etl4 T C 2: 20,530,189 Y152H probably damaging Het
Fbxo18 A T 2: 11,747,158 S910T possibly damaging Het
Gm10142 T C 10: 77,716,113 S103P probably benign Het
Gm12886 A G 4: 121,423,032 S16P unknown Het
Herc1 C T 9: 66,492,011 Q4282* probably null Het
Htr2a A T 14: 74,706,282 E434V probably benign Het
Iqsec3 T C 6: 121,412,934 probably benign Het
Islr A C 9: 58,157,624 V200G probably damaging Het
Katnal1 T C 5: 148,878,927 D400G probably benign Het
Lonrf2 A G 1: 38,811,832 probably benign Het
Lrp2 A T 2: 69,464,636 L3446Q probably damaging Het
Med12l G A 3: 59,257,373 V1425I probably benign Het
Myh13 T C 11: 67,360,274 probably benign Het
Nutm2 T G 13: 50,469,908 S214A probably benign Het
Olfr1451 T C 19: 12,999,708 S241P probably damaging Het
Olfr433 T A 1: 174,041,973 W8R possibly damaging Het
Olfr820 C A 10: 130,017,556 A65E possibly damaging Het
Olfr93 A G 17: 37,151,774 F66S probably damaging Het
Pax5 A T 4: 44,691,919 M109K probably damaging Het
Pfkfb2 G A 1: 130,700,835 R345W probably damaging Het
Pkd1l3 A G 8: 109,616,345 D105G unknown Het
Prdm11 A G 2: 92,975,519 V362A probably benign Het
Prex2 T C 1: 11,101,169 probably null Het
Prl8a1 T C 13: 27,576,941 T103A possibly damaging Het
Rgl1 T C 1: 152,533,606 I493V probably damaging Het
Rimkla A G 4: 119,477,949 V79A possibly damaging Het
Ryr2 A T 13: 11,619,496 S3791R possibly damaging Het
Sh3rf2 C A 18: 42,156,157 S681* probably null Het
Stmnd1 T A 13: 46,285,553 I87K probably benign Het
Tspan8 C A 10: 115,839,877 F149L probably benign Het
Tspan8 A C 10: 115,839,878 K150Q probably benign Het
Ttn T C 2: 76,942,376 E2425G probably damaging Het
Other mutations in Gpr146
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01355:Gpr146 APN 5 139378904 intron probably benign
IGL02152:Gpr146 APN 5 139392712 missense probably damaging 1.00
IGL02392:Gpr146 APN 5 139392778 missense probably damaging 0.99
IGL02828:Gpr146 APN 5 139392821 missense probably damaging 0.97
IGL03095:Gpr146 APN 5 139392950 missense probably benign 0.11
R0360:Gpr146 UTSW 5 139379178 intron probably benign
R0364:Gpr146 UTSW 5 139379178 intron probably benign
R0746:Gpr146 UTSW 5 139393222 missense probably damaging 1.00
R1446:Gpr146 UTSW 5 139393422 missense probably benign 0.00
R1507:Gpr146 UTSW 5 139393369 missense probably benign
R1758:Gpr146 UTSW 5 139393382 missense probably benign 0.34
R2032:Gpr146 UTSW 5 139379147 intron probably benign
R6513:Gpr146 UTSW 5 139392818 missense probably damaging 1.00
R6797:Gpr146 UTSW 5 139393040 missense possibly damaging 0.79
R7830:Gpr146 UTSW 5 139392602 missense probably benign 0.02
X0064:Gpr146 UTSW 5 139378909 intron probably benign
Posted On2015-04-16