Incidental Mutation 'IGL02369:Prl8a1'
ID290863
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prl8a1
Ensembl Gene ENSMUSG00000019756
Gene Nameprolactin family 8, subfamily a, member 1
Synonyms3830403L08Rik, 1600017L04Rik, Plpcd, PLP-Cd, Prlpc4
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.054) question?
Stock #IGL02369
Quality Score
Status
Chromosome13
Chromosomal Location27573922-27582171 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 27576941 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 103 (T103A)
Ref Sequence ENSEMBL: ENSMUSP00000093616 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000006664] [ENSMUST00000095926]
Predicted Effect possibly damaging
Transcript: ENSMUST00000006664
AA Change: T103A

PolyPhen 2 Score 0.478 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000006664
Gene: ENSMUSG00000019756
AA Change: T103A

DomainStartEndE-ValueType
Pfam:Hormone_1 16 240 7.2e-60 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000095926
AA Change: T103A

PolyPhen 2 Score 0.584 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000093616
Gene: ENSMUSG00000019756
AA Change: T103A

DomainStartEndE-ValueType
Pfam:Hormone_1 16 193 1e-39 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adck2 G T 6: 39,574,744 L148F probably damaging Het
Arhgef10 G A 8: 14,997,551 R1138H probably damaging Het
Arpp21 T C 9: 112,119,198 T668A probably benign Het
Atp6v0b T A 4: 117,885,653 I79F possibly damaging Het
Atp8b5 A T 4: 43,334,205 N324Y probably benign Het
Bach2 A G 4: 32,579,975 I610M possibly damaging Het
Casr G T 16: 36,494,689 D929E probably benign Het
Cbln2 T C 18: 86,713,354 S96P probably damaging Het
Cpxm1 T C 2: 130,396,424 K73E probably damaging Het
Erap1 A G 13: 74,666,526 Y457C probably benign Het
Etl4 T C 2: 20,530,189 Y152H probably damaging Het
Fbxo18 A T 2: 11,747,158 S910T possibly damaging Het
Gm10142 T C 10: 77,716,113 S103P probably benign Het
Gm12886 A G 4: 121,423,032 S16P unknown Het
Gpr146 T C 5: 139,392,688 Y82H probably benign Het
Herc1 C T 9: 66,492,011 Q4282* probably null Het
Htr2a A T 14: 74,706,282 E434V probably benign Het
Iqsec3 T C 6: 121,412,934 probably benign Het
Islr A C 9: 58,157,624 V200G probably damaging Het
Katnal1 T C 5: 148,878,927 D400G probably benign Het
Lonrf2 A G 1: 38,811,832 probably benign Het
Lrp2 A T 2: 69,464,636 L3446Q probably damaging Het
Med12l G A 3: 59,257,373 V1425I probably benign Het
Myh13 T C 11: 67,360,274 probably benign Het
Nutm2 T G 13: 50,469,908 S214A probably benign Het
Olfr1451 T C 19: 12,999,708 S241P probably damaging Het
Olfr433 T A 1: 174,041,973 W8R possibly damaging Het
Olfr820 C A 10: 130,017,556 A65E possibly damaging Het
Olfr93 A G 17: 37,151,774 F66S probably damaging Het
Pax5 A T 4: 44,691,919 M109K probably damaging Het
Pfkfb2 G A 1: 130,700,835 R345W probably damaging Het
Pkd1l3 A G 8: 109,616,345 D105G unknown Het
Prdm11 A G 2: 92,975,519 V362A probably benign Het
Prex2 T C 1: 11,101,169 probably null Het
Rgl1 T C 1: 152,533,606 I493V probably damaging Het
Rimkla A G 4: 119,477,949 V79A possibly damaging Het
Ryr2 A T 13: 11,619,496 S3791R possibly damaging Het
Sh3rf2 C A 18: 42,156,157 S681* probably null Het
Stmnd1 T A 13: 46,285,553 I87K probably benign Het
Tspan8 C A 10: 115,839,877 F149L probably benign Het
Tspan8 A C 10: 115,839,878 K150Q probably benign Het
Ttn T C 2: 76,942,376 E2425G probably damaging Het
Other mutations in Prl8a1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02259:Prl8a1 APN 13 27582106 missense probably benign 0.23
IGL03257:Prl8a1 APN 13 27575673 missense probably damaging 1.00
IGL02837:Prl8a1 UTSW 13 27575634 missense probably damaging 1.00
R0838:Prl8a1 UTSW 13 27574025 missense probably damaging 1.00
R1480:Prl8a1 UTSW 13 27574072 missense possibly damaging 0.84
R1973:Prl8a1 UTSW 13 27576934 missense probably benign 0.07
R2352:Prl8a1 UTSW 13 27575589 missense probably damaging 1.00
R2396:Prl8a1 UTSW 13 27574024 missense probably benign 0.00
R3732:Prl8a1 UTSW 13 27579733 missense probably damaging 0.98
R3874:Prl8a1 UTSW 13 27575458 missense possibly damaging 0.53
R4895:Prl8a1 UTSW 13 27575530 missense probably benign 0.20
R5135:Prl8a1 UTSW 13 27579819 splice site probably null
R5139:Prl8a1 UTSW 13 27574066 missense probably damaging 0.98
R5908:Prl8a1 UTSW 13 27574057 missense probably benign 0.00
R6232:Prl8a1 UTSW 13 27575574 missense possibly damaging 0.86
R6262:Prl8a1 UTSW 13 27574143 missense possibly damaging 0.95
R7203:Prl8a1 UTSW 13 27574189 missense probably damaging 0.99
R7243:Prl8a1 UTSW 13 27582103 missense probably damaging 1.00
R7372:Prl8a1 UTSW 13 27574106 missense probably damaging 0.97
R7485:Prl8a1 UTSW 13 27574085 missense probably damaging 1.00
Posted On2015-04-16