Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02370:Zfp574'

290888

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp574

Ensembl Gene

ENSMUSG00000045252

Gene Name

zinc finger protein 574

Synonyms

A630056B21Rik

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL02370

Quality Score

Status

Chromosome

Chromosomal Location

25072567-25083492 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 25079589 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Serine at position 12 (I12S)

Ref Sequence

ENSEMBL: ENSMUSP00000136547 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000053410] [ENSMUST00000179556]

AlphaFold

Q8BY46

Predicted Effect

possibly damaging
Transcript: ENSMUST00000053410
AA Change: I12S

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000057817
Gene: ENSMUSG00000045252
AA Change: I12S

Domain	Start	End	E-Value	Type
ZnF_C2H2	16	38	4.98e-1	SMART
ZnF_C2H2	76	98	4.05e-1	SMART
low complexity region	107	118	N/A	INTRINSIC
ZnF_C2H2	126	148	1.99e0	SMART
low complexity region	156	173	N/A	INTRINSIC
ZnF_C2H2	213	235	4.4e-2	SMART
low complexity region	237	254	N/A	INTRINSIC
low complexity region	289	298	N/A	INTRINSIC
ZnF_C2H2	312	334	7.15e-2	SMART
ZnF_C2H2	339	361	1.04e-3	SMART
ZnF_C2H2	367	389	4.12e0	SMART
ZnF_C2H2	395	416	2.12e1	SMART
low complexity region	418	434	N/A	INTRINSIC
ZnF_C2H2	469	492	1.03e-2	SMART
ZnF_C2H2	498	520	2.75e-3	SMART
ZnF_C2H2	526	548	3.39e-3	SMART
ZnF_C2H2	554	576	2.75e-3	SMART
ZnF_C2H2	582	604	2.86e-1	SMART
ZnF_C2H2	610	633	1.25e-1	SMART
ZnF_C2H2	639	659	4.5e1	SMART
low complexity region	660	666	N/A	INTRINSIC
ZnF_C2H2	670	692	2.29e0	SMART
ZnF_C2H2	742	764	2.91e-2	SMART
ZnF_C2H2	770	792	5.59e-4	SMART
ZnF_C2H2	798	820	3.34e-2	SMART
ZnF_C2H2	826	848	4.24e-4	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000179556
AA Change: I12S

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000136547
Gene: ENSMUSG00000045252
AA Change: I12S

Domain	Start	End	E-Value	Type
ZnF_C2H2	16	38	4.98e-1	SMART
ZnF_C2H2	76	98	4.05e-1	SMART
low complexity region	107	118	N/A	INTRINSIC
ZnF_C2H2	126	148	1.99e0	SMART
low complexity region	156	173	N/A	INTRINSIC
ZnF_C2H2	213	235	4.4e-2	SMART
low complexity region	237	254	N/A	INTRINSIC
low complexity region	289	298	N/A	INTRINSIC
ZnF_C2H2	312	334	7.15e-2	SMART
ZnF_C2H2	339	361	1.04e-3	SMART
ZnF_C2H2	367	389	4.12e0	SMART
ZnF_C2H2	395	416	2.12e1	SMART
low complexity region	418	434	N/A	INTRINSIC
ZnF_C2H2	469	492	1.03e-2	SMART
ZnF_C2H2	498	520	2.75e-3	SMART
ZnF_C2H2	526	548	3.39e-3	SMART
ZnF_C2H2	554	576	2.75e-3	SMART
ZnF_C2H2	582	604	2.86e-1	SMART
ZnF_C2H2	610	633	1.25e-1	SMART
ZnF_C2H2	639	659	4.5e1	SMART
low complexity region	660	666	N/A	INTRINSIC
ZnF_C2H2	670	692	2.29e0	SMART
ZnF_C2H2	742	764	2.91e-2	SMART
ZnF_C2H2	770	792	5.59e-4	SMART
ZnF_C2H2	798	820	3.34e-2	SMART
ZnF_C2H2	826	848	4.24e-4	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206530

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206733

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4732471J01Rik	T	C	7: 25,384,888 (GRCm38)		probably benign	Het
Abra	T	C	15: 41,869,244 (GRCm38)	D142G	probably damaging	Het
Aldh9a1	A	G	1: 167,356,532 (GRCm38)	N199D	probably damaging	Het
Baz2b	A	T	2: 59,923,589 (GRCm38)	I1130N	possibly damaging	Het
Cacna1s	A	G	1: 136,085,347 (GRCm38)	I312V	probably damaging	Het
Chrd	A	G	16: 20,735,791 (GRCm38)	M367V	possibly damaging	Het
Clec12a	C	T	6: 129,354,576 (GRCm38)	A160V	possibly damaging	Het
Cnnm1	T	C	19: 43,471,950 (GRCm38)		probably null	Het
Cntnap3	A	T	13: 64,751,751 (GRCm38)	M976K	probably benign	Het
Cyp27b1	T	C	10: 127,050,674 (GRCm38)		probably benign	Het
Ddx54	T	A	5: 120,619,787 (GRCm38)	L226Q	probably damaging	Het
Dnah7a	A	G	1: 53,635,397 (GRCm38)	V407A	probably benign	Het
Elp4	A	G	2: 105,794,592 (GRCm38)	S201P	probably damaging	Het
Exoc3	A	T	13: 74,192,761 (GRCm38)	V308D	probably benign	Het
Exosc3	A	G	4: 45,319,671 (GRCm38)	I117T	probably damaging	Het
Gbx2	A	T	1: 89,929,149 (GRCm38)		probably benign	Het
Hnf1b	A	C	11: 83,882,733 (GRCm38)	T253P	possibly damaging	Het
Inhca	A	G	9: 103,263,074 (GRCm38)	V482A	probably benign	Het
Itih5	A	T	2: 10,186,975 (GRCm38)	Y107F	probably benign	Het
Kcnb2	A	G	1: 15,710,935 (GRCm38)	N677S	probably benign	Het
Knstrn	T	A	2: 118,823,788 (GRCm38)		probably null	Het
Lin9	G	T	1: 180,688,018 (GRCm38)	C451F	probably damaging	Het
Mast1	A	C	8: 84,912,254 (GRCm38)	V1482G	probably benign	Het
Mroh4	A	G	15: 74,625,541 (GRCm38)	F144L	probably benign	Het
Myrf	T	C	19: 10,214,140 (GRCm38)	N945D	probably benign	Het
Nfrkb	G	A	9: 31,389,012 (GRCm38)	G33D	probably benign	Het
Or5m9b	C	A	2: 86,074,788 (GRCm38)	T16K	probably damaging	Het
P2ry13	T	C	3: 59,209,465 (GRCm38)	I297M	probably damaging	Het
Pcdhb21	T	A	18: 37,514,592 (GRCm38)		probably null	Het
Pitpnm3	A	G	11: 72,051,858 (GRCm38)	Y868H	probably benign	Het
Pou2f3	G	A	9: 43,137,348 (GRCm38)	R266W	probably damaging	Het
Rcn3	T	C	7: 45,083,333 (GRCm38)	S304G	probably benign	Het
Rinl	A	G	7: 28,794,972 (GRCm38)		probably null	Het
Sema5a	T	C	15: 32,682,299 (GRCm38)		probably benign	Het
Sipa1l2	A	G	8: 125,480,269 (GRCm38)	L565P	probably damaging	Het
Slc5a9	A	G	4: 111,877,629 (GRCm38)	I656T	probably benign	Het
Sptan1	A	G	2: 30,030,740 (GRCm38)	K2404R	probably damaging	Het
Tars3	C	A	7: 65,661,165 (GRCm38)	P314Q	probably benign	Het
Tbc1d14	C	T	5: 36,495,218 (GRCm38)	V627I	possibly damaging	Het
Tdpoz8	A	G	3: 93,074,047 (GRCm38)	D124G	possibly damaging	Het
Tfcp2	A	T	15: 100,512,304 (GRCm38)	V394D	probably damaging	Het
Trerf1	C	T	17: 47,314,461 (GRCm38)		noncoding transcript	Het
Ucp2	A	G	7: 100,498,384 (GRCm38)	N190S	probably damaging	Het
Vmn2r124	A	G	17: 18,064,191 (GRCm38)	Q498R	probably benign	Het
Yeats2	T	A	16: 20,150,471 (GRCm38)	I4N	probably damaging	Het
Zscan29	T	A	2: 121,163,833 (GRCm38)	E522V	probably benign	Het

Other mutations in Zfp574

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00228:Zfp574	APN	7	25,081,590 (GRCm38)	missense	probably benign	0.00
IGL02706:Zfp574	APN	7	25,081,365 (GRCm38)	missense	probably damaging	0.98
IGL03119:Zfp574	APN	7	25,080,473 (GRCm38)	missense	probably benign
glue	UTSW	7	25,081,090 (GRCm38)	missense
BB004:Zfp574	UTSW	7	25,080,147 (GRCm38)	missense	probably benign
BB014:Zfp574	UTSW	7	25,080,147 (GRCm38)	missense	probably benign
R0866:Zfp574	UTSW	7	25,079,898 (GRCm38)	missense	probably damaging	1.00
R2429:Zfp574	UTSW	7	25,080,057 (GRCm38)	nonsense	probably null
R3123:Zfp574	UTSW	7	25,081,601 (GRCm38)	missense	possibly damaging	0.88
R3124:Zfp574	UTSW	7	25,081,601 (GRCm38)	missense	possibly damaging	0.88
R3125:Zfp574	UTSW	7	25,081,601 (GRCm38)	missense	possibly damaging	0.88
R4581:Zfp574	UTSW	7	25,081,313 (GRCm38)	missense	probably damaging	0.98
R4591:Zfp574	UTSW	7	25,079,544 (GRCm38)	start gained	probably benign
R4915:Zfp574	UTSW	7	25,080,726 (GRCm38)	missense	probably damaging	0.98
R4953:Zfp574	UTSW	7	25,080,963 (GRCm38)	missense	probably damaging	0.97
R5305:Zfp574	UTSW	7	25,081,090 (GRCm38)	missense
R5541:Zfp574	UTSW	7	25,081,950 (GRCm38)	missense	probably damaging	0.99
R5934:Zfp574	UTSW	7	25,080,332 (GRCm38)	missense	probably benign
R6088:Zfp574	UTSW	7	25,080,339 (GRCm38)	missense	probably benign	0.01
R7061:Zfp574	UTSW	7	25,080,197 (GRCm38)	missense	possibly damaging	0.95
R7563:Zfp574	UTSW	7	25,081,352 (GRCm38)	missense	possibly damaging	0.94
R7615:Zfp574	UTSW	7	25,080,576 (GRCm38)	missense	possibly damaging	0.95
R7927:Zfp574	UTSW	7	25,080,147 (GRCm38)	missense	probably benign
R8017:Zfp574	UTSW	7	25,080,670 (GRCm38)	nonsense	probably null
R8019:Zfp574	UTSW	7	25,080,670 (GRCm38)	nonsense	probably null
R8788:Zfp574	UTSW	7	25,080,391 (GRCm38)	missense	unknown
R8871:Zfp574	UTSW	7	25,081,137 (GRCm38)	missense	probably damaging	0.99
R8915:Zfp574	UTSW	7	25,081,344 (GRCm38)	missense	probably damaging	1.00
R9484:Zfp574	UTSW	7	25,081,979 (GRCm38)	missense	possibly damaging	0.77
R9533:Zfp574	UTSW	7	25,080,954 (GRCm38)	missense	probably damaging	1.00
R9606:Zfp574	UTSW	7	25,081,215 (GRCm38)	missense	probably damaging	1.00
R9623:Zfp574	UTSW	7	25,081,090 (GRCm38)	missense
X0026:Zfp574	UTSW	7	25,081,052 (GRCm38)	missense	probably damaging	0.99

Posted On

2015-04-16