Incidental Mutation 'IGL02371:Olfr266'
ID290929
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr266
Ensembl Gene ENSMUSG00000043529
Gene Nameolfactory receptor 266
SynonymsMOR122-2, GA_x6K02T2N6GK-529983-529033
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.085) question?
Stock #IGL02371
Quality Score
Status
Chromosome3
Chromosomal Location106820485-106826287 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 106822046 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Tyrosine at position 171 (F171Y)
Ref Sequence ENSEMBL: ENSMUSP00000150519 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059486] [ENSMUST00000213616] [ENSMUST00000216610]
Predicted Effect probably damaging
Transcript: ENSMUST00000059486
AA Change: F171Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000054070
Gene: ENSMUSG00000043529
AA Change: F171Y

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 1.2e-58 PFAM
Pfam:7tm_1 44 293 5.4e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213616
AA Change: F171Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000216610
AA Change: F171Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arfgef3 T C 10: 18,646,539 T580A probably benign Het
Casp2 T A 6: 42,267,968 D100E probably benign Het
Cd1d1 C A 3: 86,998,881 R29L probably benign Het
Cdc45 C T 16: 18,798,729 M200I probably benign Het
Cyct A G 2: 76,354,090 *106R probably null Het
Enam A G 5: 88,502,809 I726V probably benign Het
Epha3 T G 16: 63,585,020 probably null Het
Erbb4 T C 1: 68,290,294 D632G probably benign Het
Fam217a T C 13: 34,911,401 N125S possibly damaging Het
Fbxo32 A T 15: 58,181,464 probably benign Het
Foxa1 T C 12: 57,542,700 T245A probably damaging Het
Gars T C 6: 55,065,467 V395A probably benign Het
Gimap5 A T 6: 48,753,003 N169I probably damaging Het
Itgav A G 2: 83,770,053 M266V probably damaging Het
Klhl14 G A 18: 21,652,181 S63F probably damaging Het
Lpp G A 16: 24,761,611 A26T probably damaging Het
Lrrc17 T C 5: 21,560,996 Y159H probably damaging Het
Lzts1 A T 8: 69,138,798 S233T probably damaging Het
Mdn1 T C 4: 32,676,860 probably benign Het
Nrf1 A T 6: 30,118,991 I382F possibly damaging Het
Olfr1287 A G 2: 111,450,009 R290G probably damaging Het
Olfr24 G T 9: 18,754,704 S310R probably benign Het
Pde9a T A 17: 31,420,285 V63D possibly damaging Het
Plcg1 T A 2: 160,753,507 N484K probably damaging Het
Plekhg4 T A 8: 105,379,059 probably null Het
Pot1b A G 17: 55,695,092 Y161H possibly damaging Het
Ptchd4 G A 17: 42,316,974 G109S possibly damaging Het
Rad51ap1 T C 6: 126,927,564 N119S probably benign Het
Rbm22 C T 18: 60,571,956 probably benign Het
Stk36 T A 1: 74,622,255 S480R probably benign Het
Ugt2b5 A T 5: 87,127,676 probably null Het
Other mutations in Olfr266
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01869:Olfr266 APN 3 106822026 missense probably benign 0.25
IGL01954:Olfr266 APN 3 106821995 missense possibly damaging 0.82
IGL02792:Olfr266 APN 3 106822140 missense probably damaging 0.98
PIT4131001:Olfr266 UTSW 3 106821966 missense probably benign 0.00
R0540:Olfr266 UTSW 3 106822513 missense probably damaging 0.99
R1925:Olfr266 UTSW 3 106822372 missense probably damaging 0.98
R2026:Olfr266 UTSW 3 106821711 missense probably benign 0.01
R4195:Olfr266 UTSW 3 106822012 nonsense probably null
R4735:Olfr266 UTSW 3 106821680 missense probably damaging 1.00
R4789:Olfr266 UTSW 3 106822292 missense possibly damaging 0.94
R4789:Olfr266 UTSW 3 106822308 missense possibly damaging 0.95
R4922:Olfr266 UTSW 3 106822260 missense probably damaging 0.99
R6318:Olfr266 UTSW 3 106822187 missense probably damaging 1.00
R6359:Olfr266 UTSW 3 106822415 missense probably damaging 0.99
R6505:Olfr266 UTSW 3 106822322 missense possibly damaging 0.87
R7605:Olfr266 UTSW 3 106822021 missense probably damaging 1.00
Z1176:Olfr266 UTSW 3 106822043 missense probably damaging 0.99
Posted On2015-04-16