Incidental Mutation 'IGL02371:Olfr24'
ID290932
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr24
Ensembl Gene ENSMUSG00000054141
Gene Nameolfactory receptor 24
SynonymsMOR132-1, GA_x6K02T2PVTD-12498544-12497603, MTPCR51
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.115) question?
Stock #IGL02371
Quality Score
Status
Chromosome9
Chromosomal Location18751507-18763996 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 18754704 bp
ZygosityHeterozygous
Amino Acid Change Serine to Arginine at position 310 (S310R)
Ref Sequence ENSEMBL: ENSMUSP00000149702 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000066997] [ENSMUST00000216754]
Predicted Effect probably benign
Transcript: ENSMUST00000066997
AA Change: S310R

PolyPhen 2 Score 0.071 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000064189
Gene: ENSMUSG00000054141
AA Change: S310R

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 5.6e-64 PFAM
Pfam:7TM_GPCR_Srsx 35 304 9.2e-9 PFAM
Pfam:7tm_1 41 290 3.2e-26 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212239
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214366
Predicted Effect probably benign
Transcript: ENSMUST00000216754
AA Change: S310R

PolyPhen 2 Score 0.071 (Sensitivity: 0.94; Specificity: 0.84)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arfgef3 T C 10: 18,646,539 T580A probably benign Het
Casp2 T A 6: 42,267,968 D100E probably benign Het
Cd1d1 C A 3: 86,998,881 R29L probably benign Het
Cdc45 C T 16: 18,798,729 M200I probably benign Het
Cyct A G 2: 76,354,090 *106R probably null Het
Enam A G 5: 88,502,809 I726V probably benign Het
Epha3 T G 16: 63,585,020 probably null Het
Erbb4 T C 1: 68,290,294 D632G probably benign Het
Fam217a T C 13: 34,911,401 N125S possibly damaging Het
Fbxo32 A T 15: 58,181,464 probably benign Het
Foxa1 T C 12: 57,542,700 T245A probably damaging Het
Gars T C 6: 55,065,467 V395A probably benign Het
Gimap5 A T 6: 48,753,003 N169I probably damaging Het
Itgav A G 2: 83,770,053 M266V probably damaging Het
Klhl14 G A 18: 21,652,181 S63F probably damaging Het
Lpp G A 16: 24,761,611 A26T probably damaging Het
Lrrc17 T C 5: 21,560,996 Y159H probably damaging Het
Lzts1 A T 8: 69,138,798 S233T probably damaging Het
Mdn1 T C 4: 32,676,860 probably benign Het
Nrf1 A T 6: 30,118,991 I382F possibly damaging Het
Olfr1287 A G 2: 111,450,009 R290G probably damaging Het
Olfr266 A T 3: 106,822,046 F171Y probably damaging Het
Pde9a T A 17: 31,420,285 V63D possibly damaging Het
Plcg1 T A 2: 160,753,507 N484K probably damaging Het
Plekhg4 T A 8: 105,379,059 probably null Het
Pot1b A G 17: 55,695,092 Y161H possibly damaging Het
Ptchd4 G A 17: 42,316,974 G109S possibly damaging Het
Rad51ap1 T C 6: 126,927,564 N119S probably benign Het
Rbm22 C T 18: 60,571,956 probably benign Het
Stk36 T A 1: 74,622,255 S480R probably benign Het
Ugt2b5 A T 5: 87,127,676 probably null Het
Other mutations in Olfr24
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02346:Olfr24 APN 9 18754769 missense probably damaging 0.97
IGL02555:Olfr24 APN 9 18755473 missense probably benign 0.40
IGL03025:Olfr24 APN 9 18755369 missense probably benign 0.00
IGL03259:Olfr24 APN 9 18755515 missense probably benign
IGL03050:Olfr24 UTSW 9 18755454 nonsense probably null
R0310:Olfr24 UTSW 9 18755333 missense possibly damaging 0.91
R0410:Olfr24 UTSW 9 18754841 missense probably damaging 0.96
R2152:Olfr24 UTSW 9 18755095 missense probably damaging 1.00
R2153:Olfr24 UTSW 9 18755095 missense probably damaging 1.00
R2918:Olfr24 UTSW 9 18755479 missense probably damaging 1.00
R4552:Olfr24 UTSW 9 18755134 missense possibly damaging 0.60
R5073:Olfr24 UTSW 9 18754822 missense possibly damaging 0.89
R5539:Olfr24 UTSW 9 18754838 missense probably damaging 0.99
R5662:Olfr24 UTSW 9 18755600 missense probably damaging 0.99
R6145:Olfr24 UTSW 9 18755569 missense probably benign 0.06
R7125:Olfr24 UTSW 9 18754878 nonsense probably null
R7196:Olfr24 UTSW 9 18755590 nonsense probably null
R7607:Olfr24 UTSW 9 18754882 missense possibly damaging 0.93
Z1177:Olfr24 UTSW 9 18755519 missense possibly damaging 0.85
Posted On2015-04-16