Incidental Mutation 'IGL02372:Olfr281'
ID290952
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr281
Ensembl Gene ENSMUSG00000032987
Gene Nameolfactory receptor 281
SynonymsMOR160-5, GA_x6K02T2NBG7-5275017-5274082
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.071) question?
Stock #IGL02372
Quality Score
Status
Chromosome15
Chromosomal Location98452588-98460395 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 98456828 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Serine at position 173 (T173S)
Ref Sequence ENSEMBL: ENSMUSP00000150530 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109163] [ENSMUST00000217517]
Predicted Effect probably damaging
Transcript: ENSMUST00000109163
AA Change: T173S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000104791
Gene: ENSMUSG00000032987
AA Change: T173S

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 3.8e-54 PFAM
Pfam:7TM_GPCR_Srsx 35 277 2.2e-5 PFAM
Pfam:7tm_1 41 288 2.4e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000217517
AA Change: T173S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700001P01Rik A T 11: 97,775,699 Y54N probably damaging Het
Alyref A G 11: 120,594,875 probably benign Het
Ankrd27 A G 7: 35,633,036 probably null Het
Arc A G 15: 74,672,105 S90P probably damaging Het
Atp6v1e1 T A 6: 120,801,123 K150N probably benign Het
Atrn T C 2: 131,002,754 probably benign Het
Ccnb1 A G 13: 100,781,316 Y259H probably damaging Het
Celsr1 A G 15: 85,929,907 V1938A probably benign Het
Ckmt2 A G 13: 91,865,224 V37A probably benign Het
Dpys G T 15: 39,793,271 P467T probably benign Het
Ehbp1l1 T C 19: 5,710,834 T1535A possibly damaging Het
Eif4enif1 T C 11: 3,229,986 L302P probably benign Het
Faf1 T G 4: 109,935,582 F584V probably benign Het
Glb1l2 G A 9: 26,796,476 R72C probably damaging Het
Gm9892 T C 8: 52,196,836 noncoding transcript Het
Hecw1 G T 13: 14,264,121 D892E probably damaging Het
Hr A G 14: 70,558,350 E474G possibly damaging Het
Ltbp1 T G 17: 75,252,406 F297V probably damaging Het
Myc A G 15: 61,987,858 N127D probably damaging Het
Nbn T A 4: 15,986,613 N671K probably benign Het
Nup210l C A 3: 90,201,971 T1607N possibly damaging Het
Osbpl1a T A 18: 12,841,313 K22* probably null Het
Phf20l1 T C 15: 66,641,801 L942P probably damaging Het
Plekhg5 C T 4: 152,102,080 R40W probably damaging Het
Pomt2 C T 12: 87,122,835 probably benign Het
Rab3gap1 A G 1: 127,919,561 probably benign Het
Sbk1 T C 7: 126,291,058 L81P probably damaging Het
Scrib G A 15: 76,048,255 P1524S probably damaging Het
Smpdl3a T A 10: 57,807,515 N240K probably benign Het
Smyd4 A T 11: 75,390,285 K195* probably null Het
Tulp3 A T 6: 128,327,598 M231K possibly damaging Het
Zfp87 A G 13: 67,520,620 probably benign Het
Other mutations in Olfr281
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00094:Olfr281 APN 15 98456418 missense possibly damaging 0.61
IGL01016:Olfr281 APN 15 98456305 utr 5 prime probably benign
IGL02730:Olfr281 APN 15 98456436 missense probably damaging 1.00
R0732:Olfr281 UTSW 15 98457078 missense possibly damaging 0.94
R1714:Olfr281 UTSW 15 98456733 missense probably damaging 1.00
R1959:Olfr281 UTSW 15 98456753 missense probably damaging 1.00
R4169:Olfr281 UTSW 15 98456997 missense probably benign 0.00
R4902:Olfr281 UTSW 15 98456915 missense probably damaging 0.99
R5014:Olfr281 UTSW 15 98456976 missense possibly damaging 0.80
R6082:Olfr281 UTSW 15 98456766 missense probably damaging 0.97
R6378:Olfr281 UTSW 15 98456544 missense probably benign 0.42
R7383:Olfr281 UTSW 15 98456697 missense probably damaging 1.00
R7850:Olfr281 UTSW 15 98457068 missense probably damaging 1.00
R7853:Olfr281 UTSW 15 98456985 missense probably benign 0.42
R7912:Olfr281 UTSW 15 98456693 missense probably benign 0.00
R8750:Olfr281 UTSW 15 98457048 missense probably damaging 0.97
Posted On2015-04-16