Incidental Mutation 'IGL02372:Zfp87'
| ID |
290979 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp87
|
| Ensembl Gene |
ENSMUSG00000097333 |
| Gene Name |
zinc finger protein 87 |
| Synonyms |
Mzf22, 2210039O17Rik, 4631412O18Rik, Zfp72, KRAB4 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.096)
|
| Stock # |
IGL02372
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
13 |
| Chromosomal Location |
67663900-67674296 bp(-) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
A to G
at 67668739 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000138087
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167914]
[ENSMUST00000180536]
[ENSMUST00000181341]
[ENSMUST00000181573]
[ENSMUST00000181767]
|
| AlphaFold |
Q8K2A4 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167914
|
| SMART Domains |
Protein: ENSMUSP00000137830
Gene: ENSMUSG00000097565
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
5 |
65 |
4.41e-34 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000180536
|
| SMART Domains |
Protein: ENSMUSP00000137812
Gene: ENSMUSG00000097333
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
5 |
51 |
7.02e-19 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000181341
|
| SMART Domains |
Protein: ENSMUSP00000137689
Gene: ENSMUSG00000097333
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
5 |
65 |
4.41e-34 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000181573
|
| SMART Domains |
Protein: ENSMUSP00000138011
Gene: ENSMUSG00000097333
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
5 |
51 |
7.02e-19 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000181767
|
| SMART Domains |
Protein: ENSMUSP00000138087
Gene: ENSMUSG00000097333
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
5 |
65 |
4.41e-34 |
SMART |
|
ZnF_C2H2
|
109 |
131 |
2.61e-4 |
SMART |
|
ZnF_C2H2
|
137 |
159 |
9.22e-5 |
SMART |
|
ZnF_C2H2
|
165 |
187 |
2.36e-2 |
SMART |
|
ZnF_C2H2
|
193 |
215 |
7.15e-2 |
SMART |
|
ZnF_C2H2
|
221 |
243 |
9.22e-5 |
SMART |
|
ZnF_C2H2
|
249 |
271 |
3.63e-3 |
SMART |
|
ZnF_C2H2
|
277 |
299 |
6.42e-4 |
SMART |
|
ZnF_C2H2
|
305 |
327 |
2.99e-4 |
SMART |
|
ZnF_C2H2
|
333 |
355 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
361 |
383 |
5.59e-4 |
SMART |
|
ZnF_C2H2
|
389 |
411 |
3.69e-4 |
SMART |
|
ZnF_C2H2
|
417 |
439 |
5.9e-3 |
SMART |
|
ZnF_C2H2
|
445 |
467 |
3.21e-4 |
SMART |
|
ZnF_C2H2
|
472 |
494 |
9.08e-4 |
SMART |
|
ZnF_C2H2
|
500 |
522 |
4.47e-3 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 32 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Alyref |
A |
G |
11: 120,485,701 (GRCm39) |
|
probably benign |
Het |
| Ankrd27 |
A |
G |
7: 35,332,461 (GRCm39) |
|
probably null |
Het |
| Arc |
A |
G |
15: 74,543,954 (GRCm39) |
S90P |
probably damaging |
Het |
| Atp6v1e1 |
T |
A |
6: 120,778,084 (GRCm39) |
K150N |
probably benign |
Het |
| Atrn |
T |
C |
2: 130,844,674 (GRCm39) |
|
probably benign |
Het |
| Ccnb1 |
A |
G |
13: 100,917,824 (GRCm39) |
Y259H |
probably damaging |
Het |
| Celsr1 |
A |
G |
15: 85,814,108 (GRCm39) |
V1938A |
probably benign |
Het |
| Ckmt2 |
A |
G |
13: 92,013,343 (GRCm39) |
V37A |
probably benign |
Het |
| Dpys |
G |
T |
15: 39,656,667 (GRCm39) |
P467T |
probably benign |
Het |
| Ehbp1l1 |
T |
C |
19: 5,760,862 (GRCm39) |
T1535A |
possibly damaging |
Het |
| Eif4enif1 |
T |
C |
11: 3,179,986 (GRCm39) |
L302P |
probably benign |
Het |
| Faf1 |
T |
G |
4: 109,792,779 (GRCm39) |
F584V |
probably benign |
Het |
| Glb1l2 |
G |
A |
9: 26,707,772 (GRCm39) |
R72C |
probably damaging |
Het |
| Gm9892 |
T |
C |
8: 52,649,871 (GRCm39) |
|
noncoding transcript |
Het |
| Hecw1 |
G |
T |
13: 14,438,706 (GRCm39) |
D892E |
probably damaging |
Het |
| Hr |
A |
G |
14: 70,795,790 (GRCm39) |
E474G |
possibly damaging |
Het |
| Ltbp1 |
T |
G |
17: 75,559,401 (GRCm39) |
F297V |
probably damaging |
Het |
| Myc |
A |
G |
15: 61,859,707 (GRCm39) |
N127D |
probably damaging |
Het |
| Nbn |
T |
A |
4: 15,986,613 (GRCm39) |
N671K |
probably benign |
Het |
| Nup210l |
C |
A |
3: 90,109,278 (GRCm39) |
T1607N |
possibly damaging |
Het |
| Or8s8 |
A |
T |
15: 98,354,709 (GRCm39) |
T173S |
probably damaging |
Het |
| Osbpl1a |
T |
A |
18: 12,974,370 (GRCm39) |
K22* |
probably null |
Het |
| Phf20l1 |
T |
C |
15: 66,513,650 (GRCm39) |
L942P |
probably damaging |
Het |
| Plekhg5 |
C |
T |
4: 152,186,537 (GRCm39) |
R40W |
probably damaging |
Het |
| Pomt2 |
C |
T |
12: 87,169,609 (GRCm39) |
|
probably benign |
Het |
| Rab3gap1 |
A |
G |
1: 127,847,298 (GRCm39) |
|
probably benign |
Het |
| Sbk1 |
T |
C |
7: 125,890,230 (GRCm39) |
L81P |
probably damaging |
Het |
| Scrib |
G |
A |
15: 75,920,104 (GRCm39) |
P1524S |
probably damaging |
Het |
| Smpdl3a |
T |
A |
10: 57,683,611 (GRCm39) |
N240K |
probably benign |
Het |
| Smyd4 |
A |
T |
11: 75,281,111 (GRCm39) |
K195* |
probably null |
Het |
| Spmap1 |
A |
T |
11: 97,666,525 (GRCm39) |
Y54N |
probably damaging |
Het |
| Tulp3 |
A |
T |
6: 128,304,561 (GRCm39) |
M231K |
possibly damaging |
Het |
|
| Other mutations in Zfp87 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02165:Zfp87
|
APN |
13 |
67,665,989 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03160:Zfp87
|
APN |
13 |
67,669,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0653:Zfp87
|
UTSW |
13 |
74,520,190 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0711:Zfp87
|
UTSW |
13 |
74,524,544 (GRCm39) |
splice site |
probably benign |
|
|
R1498:Zfp87
|
UTSW |
13 |
74,520,736 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3801:Zfp87
|
UTSW |
13 |
67,669,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4032:Zfp87
|
UTSW |
13 |
74,520,449 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R4629:Zfp87
|
UTSW |
13 |
74,520,512 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4950:Zfp87
|
UTSW |
13 |
67,666,018 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5604:Zfp87
|
UTSW |
13 |
67,665,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6111:Zfp87
|
UTSW |
13 |
74,520,504 (GRCm39) |
missense |
probably benign |
0.31 |
|
R6130:Zfp87
|
UTSW |
13 |
74,520,460 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R6277:Zfp87
|
UTSW |
13 |
74,520,643 (GRCm39) |
nonsense |
probably null |
|
|
R6392:Zfp87
|
UTSW |
13 |
67,664,986 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6800:Zfp87
|
UTSW |
13 |
74,520,080 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6909:Zfp87
|
UTSW |
13 |
74,519,861 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7009:Zfp87
|
UTSW |
13 |
67,665,173 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7183:Zfp87
|
UTSW |
13 |
67,665,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7298:Zfp87
|
UTSW |
13 |
74,520,513 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7330:Zfp87
|
UTSW |
13 |
74,523,153 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7341:Zfp87
|
UTSW |
13 |
74,520,467 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7448:Zfp87
|
UTSW |
13 |
67,665,163 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7597:Zfp87
|
UTSW |
13 |
67,665,412 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8696:Zfp87
|
UTSW |
13 |
74,520,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9280:Zfp87
|
UTSW |
13 |
74,520,803 (GRCm39) |
missense |
probably benign |
0.16 |
|
R9429:Zfp87
|
UTSW |
13 |
74,520,703 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9780:Zfp87
|
UTSW |
13 |
67,665,241 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9782:Zfp87
|
UTSW |
13 |
74,520,932 (GRCm39) |
missense |
probably benign |
0.00 |
|
RF014:Zfp87
|
UTSW |
13 |
74,523,173 (GRCm39) |
missense |
probably benign |
0.17 |
|
Z1176:Zfp87
|
UTSW |
13 |
67,674,275 (GRCm39) |
start gained |
probably benign |
|
|
Z1177:Zfp87
|
UTSW |
13 |
74,519,911 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Posted On |
2015-04-16 |
Incidental Mutation