Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02374:Vmn2r104'

291018

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r104

Ensembl Gene

ENSMUSG00000090315

Gene Name

vomeronasal 2, receptor 104

Synonyms

V2r7

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.124) question?

Stock #

IGL02374

Quality Score

Status

Chromosome

Chromosomal Location

20029425-20048205 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 20042786 bp

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 138 (I138V)

Ref Sequence

ENSEMBL: ENSMUSP00000129895 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168050]

Predicted Effect

probably benign
Transcript: ENSMUST00000168050
AA Change: I138V

PolyPhen 2 Score 0.337 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000129895
Gene: ENSMUSG00000090315
AA Change: I138V

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	85	457	4e-38	PFAM
Pfam:NCD3G	512	565	2.1e-20	PFAM
Pfam:7tm_3	598	833	1.7e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arl5b	T	C	2: 15,068,192	Y35H	probably damaging	Het
Ccdc144b	T	C	3: 36,019,959	Q347R	possibly damaging	Het
Cnksr3	A	G	10: 7,120,335	S300P	probably damaging	Het
Col27a1	T	C	4: 63,293,249	S1013P	possibly damaging	Het
Cyp39a1	A	G	17: 43,749,981		probably benign	Het
Deptor	G	T	15: 55,180,961	L174F	probably damaging	Het
Fah	T	C	7: 84,605,701	E8G	probably benign	Het
Fastk	C	A	5: 24,444,249	A47S	possibly damaging	Het
Foxl2	C	T	9: 98,955,832	L58F	probably damaging	Het
Igf2bp2	G	T	16: 22,081,868	H106Q	probably benign	Het
Igkv12-47	T	C	6: 69,750,975	T71A	probably benign	Het
Ino80d	T	C	1: 63,086,061	I81V	possibly damaging	Het
Ints9	G	A	14: 65,039,333	E650K	probably benign	Het
Klc2	T	C	19: 5,110,410	N408S	possibly damaging	Het
Klhl32	A	T	4: 24,743,856		probably null	Het
Ksr1	C	T	11: 79,028,491	G504D	probably benign	Het
Lonp2	C	A	8: 86,709,045	D636E	probably damaging	Het
Lpin3	G	A	2: 160,895,838		probably benign	Het
Mcmdc2	C	T	1: 9,911,982	A56V	possibly damaging	Het
Olfr1208	A	T	2: 88,897,459	I46N	probably damaging	Het
Olfr129	A	T	17: 38,055,521	V24D	probably damaging	Het
Pex1	T	C	5: 3,635,481	I1163T	probably benign	Het
Ppp1r3a	C	T	6: 14,718,600	V772I	probably damaging	Het
Ptbp2	A	T	3: 119,720,693		probably benign	Het
Rell1	A	T	5: 63,937,808	I105K	possibly damaging	Het
Sis	A	T	3: 72,925,456	S1003T	probably benign	Het
Slc26a3	T	A	12: 31,470,833		probably benign	Het
Stap1	G	A	5: 86,096,551	G264R	probably damaging	Het
Tmem176b	T	C	6: 48,834,626	N30D	possibly damaging	Het
Tmprss15	A	T	16: 79,035,168	Y367N	probably benign	Het
Ttc41	A	G	10: 86,775,951	D1061G	probably damaging	Het
Ufl1	A	C	4: 25,259,237	D460E	probably benign	Het
Wdfy2	T	C	14: 62,934,384	S194P	probably benign	Het
Zfp408	A	C	2: 91,645,811	C333G	probably damaging	Het
Zfp592	T	C	7: 81,024,983	V565A	probably damaging	Het

Other mutations in Vmn2r104

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00427:Vmn2r104	APN	17	20038239	missense	probably damaging	0.98
IGL01098:Vmn2r104	APN	17	20048096	missense	probably benign	0.27
IGL01333:Vmn2r104	APN	17	20042793	missense	probably benign	0.17
IGL01527:Vmn2r104	APN	17	20042896	missense	possibly damaging	0.82
IGL01773:Vmn2r104	APN	17	20040668	missense	probably benign	0.10
IGL01939:Vmn2r104	APN	17	20029925	missense	probably damaging	0.99
IGL02121:Vmn2r104	APN	17	20041794	nonsense	probably null
IGL02305:Vmn2r104	APN	17	20042856	missense	probably benign	0.09
IGL03260:Vmn2r104	APN	17	20042821	missense	probably benign	0.05
IGL03366:Vmn2r104	APN	17	20029604	missense	probably damaging	1.00
R0091:Vmn2r104	UTSW	17	20041813	missense	possibly damaging	0.79
R0125:Vmn2r104	UTSW	17	20029807	missense	probably damaging	0.98
R0257:Vmn2r104	UTSW	17	20029627	missense	probably damaging	1.00
R0381:Vmn2r104	UTSW	17	20048002	nonsense	probably null
R0709:Vmn2r104	UTSW	17	20042904	missense	probably damaging	1.00
R0786:Vmn2r104	UTSW	17	20042725	missense	probably benign
R1575:Vmn2r104	UTSW	17	20042215	missense	probably damaging	1.00
R1827:Vmn2r104	UTSW	17	20042235	missense	probably damaging	0.97
R1932:Vmn2r104	UTSW	17	20040769	missense	probably damaging	1.00
R1956:Vmn2r104	UTSW	17	20042051	missense	probably damaging	0.98
R2203:Vmn2r104	UTSW	17	20029821	missense	probably benign	0.05
R2205:Vmn2r104	UTSW	17	20029821	missense	probably benign	0.05
R2859:Vmn2r104	UTSW	17	20048193	missense	possibly damaging	0.82
R3701:Vmn2r104	UTSW	17	20029556	missense	probably damaging	1.00
R3834:Vmn2r104	UTSW	17	20029921	missense	probably benign	0.02
R4151:Vmn2r104	UTSW	17	20029885	missense	probably damaging	1.00
R4470:Vmn2r104	UTSW	17	20042241	missense	probably damaging	1.00
R4625:Vmn2r104	UTSW	17	20048181	missense	probably benign	0.00
R4754:Vmn2r104	UTSW	17	20040768	nonsense	probably null
R4911:Vmn2r104	UTSW	17	20030026	missense	probably benign	0.00
R5270:Vmn2r104	UTSW	17	20038266	missense	probably damaging	1.00
R5279:Vmn2r104	UTSW	17	20041884	missense	probably benign	0.07
R5311:Vmn2r104	UTSW	17	20029901	missense	probably damaging	1.00
R5370:Vmn2r104	UTSW	17	20030188	missense	probably damaging	0.97
R5461:Vmn2r104	UTSW	17	20030081	missense	probably damaging	1.00
R5683:Vmn2r104	UTSW	17	20040719	nonsense	probably null
R5795:Vmn2r104	UTSW	17	20030110	missense	probably benign	0.02
R5795:Vmn2r104	UTSW	17	20030282	missense	possibly damaging	0.89
R5970:Vmn2r104	UTSW	17	20029471	missense	probably benign	0.01
R5983:Vmn2r104	UTSW	17	20041708	missense	probably damaging	1.00
R5992:Vmn2r104	UTSW	17	20029485	missense	probably damaging	1.00
R6066:Vmn2r104	UTSW	17	20038311	missense	possibly damaging	0.69
R6156:Vmn2r104	UTSW	17	20041647	missense	probably damaging	1.00
R6182:Vmn2r104	UTSW	17	20030245	missense	probably benign	0.16
R6245:Vmn2r104	UTSW	17	20041567	missense	possibly damaging	0.69
R6333:Vmn2r104	UTSW	17	20029586	missense	probably benign	0.30
R6573:Vmn2r104	UTSW	17	20042225	missense	probably damaging	1.00
R7101:Vmn2r104	UTSW	17	20030096	missense	possibly damaging	0.65
R7123:Vmn2r104	UTSW	17	20040826	missense	probably benign	0.12
R7485:Vmn2r104	UTSW	17	20029475	missense	probably benign	0.01
R7514:Vmn2r104	UTSW	17	20029529	missense	probably damaging	1.00
R7634:Vmn2r104	UTSW	17	20041709	missense	possibly damaging	0.48
R7958:Vmn2r104	UTSW	17	20042726	missense	probably benign
R8031:Vmn2r104	UTSW	17	20042786	missense	probably benign	0.34
R8094:Vmn2r104	UTSW	17	20030221	missense	possibly damaging	0.77
R8191:Vmn2r104	UTSW	17	20030203	missense	possibly damaging	0.89
R8308:Vmn2r104	UTSW	17	20040778	missense	possibly damaging	0.55
RF007:Vmn2r104	UTSW	17	20048040	missense	probably benign	0.36
Z1177:Vmn2r104	UTSW	17	20029789	missense	probably damaging	1.00

Posted On

2015-04-16