Incidental Mutation 'IGL00987:Lmf2'
ID 29114
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lmf2
Ensembl Gene ENSMUSG00000022614
Gene Name lipase maturation factor 2
Synonyms Tmem112b, Tmem153
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # IGL00987
Quality Score
Status
Chromosome 15
Chromosomal Location 89235207-89239862 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 89238771 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 115 (Y115C)
Ref Sequence ENSEMBL: ENSMUSP00000023283 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023283] [ENSMUST00000036987] [ENSMUST00000074552] [ENSMUST00000088717] [ENSMUST00000229111] [ENSMUST00000145259]
AlphaFold Q8C3X8
Predicted Effect probably benign
Transcript: ENSMUST00000023283
AA Change: Y115C

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000023283
Gene: ENSMUSG00000022614
AA Change: Y115C

DomainStartEndE-ValueType
transmembrane domain 12 34 N/A INTRINSIC
transmembrane domain 87 109 N/A INTRINSIC
Pfam:LMF1 122 589 5.6e-164 PFAM
low complexity region 679 693 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000036987
SMART Domains Protein: ENSMUSP00000036900
Gene: ENSMUSG00000008690

DomainStartEndE-ValueType
Pfam:DUF1032 20 576 N/A PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000074552
SMART Domains Protein: ENSMUSP00000074139
Gene: ENSMUSG00000008690

DomainStartEndE-ValueType
Pfam:DUF1032 51 607 N/A PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000088717
SMART Domains Protein: ENSMUSP00000086095
Gene: ENSMUSG00000008690

DomainStartEndE-ValueType
Pfam:CNDH2_N 11 123 1.2e-48 PFAM
Pfam:CNDH2_M 147 285 2.1e-20 PFAM
Pfam:CNDH2_C 308 598 1.9e-90 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123889
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141643
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145793
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231067
Predicted Effect probably benign
Transcript: ENSMUST00000229111
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229291
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231107
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230112
Predicted Effect probably benign
Transcript: ENSMUST00000145259
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229436
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229308
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230523
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot9 T C X: 154,078,177 (GRCm39) I241T probably benign Het
Atp5mc3 T A 2: 73,740,270 (GRCm39) R19* probably null Het
Celf4 T C 18: 25,620,007 (GRCm39) D420G probably damaging Het
Cideb C A 14: 55,992,017 (GRCm39) R179L possibly damaging Het
Cmtr1 G A 17: 29,916,143 (GRCm39) R591H probably benign Het
Dync1li2 A T 8: 105,169,130 (GRCm39) S34T possibly damaging Het
Eri2 A G 7: 119,390,389 (GRCm39) Y80H probably damaging Het
Eya2 A G 2: 165,596,401 (GRCm39) E304G probably damaging Het
Fam135a A C 1: 24,094,979 (GRCm39) L130V probably damaging Het
Fancb A T X: 163,774,594 (GRCm39) K410N probably damaging Het
Gabpb2 A C 3: 95,107,502 (GRCm39) V191G probably damaging Het
Gfm1 A G 3: 67,345,893 (GRCm39) H197R possibly damaging Het
Gm11595 A G 11: 99,663,365 (GRCm39) V105A unknown Het
Hectd3 T A 4: 116,856,840 (GRCm39) D462E probably damaging Het
Herc1 G T 9: 66,315,334 (GRCm39) V1139L probably benign Het
Itgal T C 7: 126,901,183 (GRCm39) F190L probably damaging Het
Krt87 G A 15: 101,336,327 (GRCm39) H109Y probably benign Het
Papolg T A 11: 23,826,377 (GRCm39) Y259F possibly damaging Het
Parn T C 16: 13,485,467 (GRCm39) I10V probably benign Het
Pdcd11 T A 19: 47,102,989 (GRCm39) probably benign Het
Phldb2 T A 16: 45,583,465 (GRCm39) Q1003L possibly damaging Het
Pigg T A 5: 108,489,944 (GRCm39) F850I probably damaging Het
Pkp4 T C 2: 59,138,701 (GRCm39) L317P probably damaging Het
Polr2a T C 11: 69,634,620 (GRCm39) probably benign Het
Prdm16 G A 4: 154,426,426 (GRCm39) T453M possibly damaging Het
Rnf144b A T 13: 47,360,969 (GRCm39) E36D possibly damaging Het
Ryr2 G A 13: 11,750,388 (GRCm39) T1961I probably damaging Het
Sash1 T A 10: 8,627,177 (GRCm39) K305I probably damaging Het
Tbc1d7 A T 13: 43,312,797 (GRCm39) I32N probably damaging Het
Thop1 T C 10: 80,917,529 (GRCm39) F623L probably damaging Het
Thsd7b G A 1: 129,541,016 (GRCm39) G297R probably damaging Het
Tln1 C A 4: 43,551,297 (GRCm39) probably benign Het
Vmn1r183 A G 7: 23,754,649 (GRCm39) N151D probably damaging Het
Other mutations in Lmf2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00896:Lmf2 APN 15 89,237,539 (GRCm39) missense probably benign 0.00
IGL00953:Lmf2 APN 15 89,238,102 (GRCm39) missense probably damaging 1.00
IGL01069:Lmf2 APN 15 89,237,091 (GRCm39) missense probably benign 0.35
IGL01340:Lmf2 APN 15 89,237,075 (GRCm39) missense probably damaging 0.98
IGL01878:Lmf2 APN 15 89,236,621 (GRCm39) missense probably damaging 1.00
IGL02588:Lmf2 APN 15 89,239,609 (GRCm39) splice site probably null
IGL02698:Lmf2 APN 15 89,238,357 (GRCm39) missense probably damaging 1.00
BB003:Lmf2 UTSW 15 89,236,624 (GRCm39) missense probably damaging 1.00
BB013:Lmf2 UTSW 15 89,236,624 (GRCm39) missense probably damaging 1.00
PIT4651001:Lmf2 UTSW 15 89,236,272 (GRCm39) missense possibly damaging 0.58
R1761:Lmf2 UTSW 15 89,236,916 (GRCm39) missense possibly damaging 0.61
R2355:Lmf2 UTSW 15 89,235,966 (GRCm39) missense possibly damaging 0.65
R2880:Lmf2 UTSW 15 89,235,856 (GRCm39) missense possibly damaging 0.59
R4896:Lmf2 UTSW 15 89,236,003 (GRCm39) missense probably benign 0.16
R5141:Lmf2 UTSW 15 89,235,810 (GRCm39) splice site probably null
R6785:Lmf2 UTSW 15 89,236,236 (GRCm39) missense probably benign 0.43
R7301:Lmf2 UTSW 15 89,239,733 (GRCm39) start gained probably benign
R7926:Lmf2 UTSW 15 89,236,624 (GRCm39) missense probably damaging 1.00
R8110:Lmf2 UTSW 15 89,236,561 (GRCm39) critical splice donor site probably null
R8274:Lmf2 UTSW 15 89,236,866 (GRCm39) missense probably damaging 1.00
R8472:Lmf2 UTSW 15 89,239,005 (GRCm39) missense possibly damaging 0.80
R9127:Lmf2 UTSW 15 89,239,771 (GRCm39) start gained probably benign
R9332:Lmf2 UTSW 15 89,239,577 (GRCm39) missense probably damaging 1.00
R9333:Lmf2 UTSW 15 89,239,577 (GRCm39) missense probably damaging 1.00
R9334:Lmf2 UTSW 15 89,239,577 (GRCm39) missense probably damaging 1.00
R9710:Lmf2 UTSW 15 89,237,419 (GRCm39) missense probably benign 0.09
Posted On 2013-04-17