Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02377:Zfp157'

291194

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp157

Ensembl Gene

ENSMUSG00000036898

Gene Name

zinc finger protein 157

Synonyms

2610020C11Rik, Roma, A630094N24Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

IGL02377

Quality Score

Status

Chromosome

Chromosomal Location

138439730-138458956 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 138445859 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tryptophan to Stop codon at position 71 (W71*)

Ref Sequence

ENSEMBL: ENSMUSP00000106537 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000085856] [ENSMUST00000100524] [ENSMUST00000110912]

AlphaFold

Q6PCM4

Predicted Effect

probably null
Transcript: ENSMUST00000085856
AA Change: W71*

SMART Domains

Protein: ENSMUSP00000083018
Gene: ENSMUSG00000036898
AA Change: W71*

Domain	Start	End	E-Value	Type
KRAB	4	64	3.64e-35	SMART
ZnF_C2H2	183	205	3.69e-4	SMART
ZnF_C2H2	211	233	3.16e-3	SMART
ZnF_C2H2	239	261	3.63e-3	SMART
ZnF_C2H2	267	289	2.24e-3	SMART
ZnF_C2H2	295	317	1.47e-3	SMART
ZnF_C2H2	323	345	1.95e-3	SMART
ZnF_C2H2	351	373	1.28e-3	SMART
ZnF_C2H2	379	401	2.4e-3	SMART
ZnF_C2H2	407	429	9.73e-4	SMART
ZnF_C2H2	435	457	4.4e-2	SMART
ZnF_C2H2	463	485	1.01e-1	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000100524
AA Change: W71*

SMART Domains

Protein: ENSMUSP00000098093
Gene: ENSMUSG00000036898
AA Change: W71*

Domain	Start	End	E-Value	Type
KRAB	4	64	3.64e-35	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000110912
AA Change: W71*

SMART Domains

Protein: ENSMUSP00000106537
Gene: ENSMUSG00000036898
AA Change: W71*

Domain	Start	End	E-Value	Type
KRAB	4	64	3.64e-35	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134706

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000137711

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000151095

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a null allele display accelerated ductal elongation during puberty and accelerated alveologenesis during pregnancy. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 64 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aatk	A	T	11: 119,937,689 (GRCm39)		probably benign	Het
Abca15	T	C	7: 119,965,133 (GRCm39)		probably benign	Het
App	T	C	16: 84,879,719 (GRCm39)	Q138R	probably benign	Het
Asah2	T	A	19: 31,986,814 (GRCm39)	I529F	probably benign	Het
Atp8b3	A	G	10: 80,356,128 (GRCm39)	S1195P	probably benign	Het
Brca1	A	G	11: 101,415,149 (GRCm39)	M134T	probably benign	Het
Cacna1s	T	C	1: 135,996,732 (GRCm39)	L111P	probably damaging	Het
Capns2	A	T	8: 93,628,215 (GRCm39)	N35Y	probably benign	Het
Ccne1	A	G	7: 37,798,415 (GRCm39)		probably null	Het
Cfap91	G	T	16: 38,153,181 (GRCm39)		probably benign	Het
Csf1r	G	T	18: 61,257,540 (GRCm39)		probably benign	Het
Dipk2b	T	A	X: 18,313,930 (GRCm39)	I131F	possibly damaging	Het
Dlg3	A	T	X: 99,817,007 (GRCm39)	Y326F	possibly damaging	Het
Dnah8	T	C	17: 31,013,770 (GRCm39)	V3837A	probably damaging	Het
Dock10	A	G	1: 80,562,711 (GRCm39)		probably null	Het
Emg1	A	G	6: 124,681,620 (GRCm39)	V208A	probably benign	Het
Eml6	T	A	11: 29,727,282 (GRCm39)	D1280V	probably damaging	Het
Ep400	T	C	5: 110,868,691 (GRCm39)	D911G	unknown	Het
Fam171a1	T	C	2: 3,224,623 (GRCm39)		probably null	Het
Fcgbp	T	C	7: 27,806,395 (GRCm39)	V2121A	possibly damaging	Het
Fggy	G	A	4: 95,511,714 (GRCm39)		probably benign	Het
Fignl1	G	T	11: 11,752,845 (GRCm39)	T70K	possibly damaging	Het
Fndc3b	T	C	3: 27,674,801 (GRCm39)	E47G	probably damaging	Het
Frmd4a	A	G	2: 4,539,385 (GRCm39)	K189E	possibly damaging	Het
Hpse	T	A	5: 100,839,199 (GRCm39)	Y383F	probably damaging	Het
Ip6k2	T	C	9: 108,681,798 (GRCm39)	L197P	probably damaging	Het
Klf1	A	C	8: 85,631,561 (GRCm39)	H375P	probably damaging	Het
Krtap6-5	T	A	16: 88,844,734 (GRCm39)		probably benign	Het
Lacc1	A	T	14: 77,267,055 (GRCm39)	S403T	probably damaging	Het
Lama3	A	G	18: 12,689,807 (GRCm39)	I2850V	possibly damaging	Het
Lats2	C	T	14: 57,929,052 (GRCm39)	R941Q	probably damaging	Het
Lgals3bp	A	T	11: 118,284,290 (GRCm39)	Y430N	probably benign	Het
Lrig3	A	T	10: 125,850,743 (GRCm39)	H1103L	probably benign	Het
Lrrc40	G	A	3: 157,742,365 (GRCm39)	M1I	probably null	Het
Magee2	A	T	X: 103,900,399 (GRCm39)	V84D	possibly damaging	Het
Msantd2	G	A	9: 37,434,602 (GRCm39)	V281I	possibly damaging	Het
Mycbpap	A	G	11: 94,394,076 (GRCm39)	V340A	probably damaging	Het
Myh6	A	T	14: 55,181,775 (GRCm39)	M1842K	probably benign	Het
Mylk4	T	C	13: 32,906,130 (GRCm39)	D145G	possibly damaging	Het
Nfkbid	C	T	7: 30,124,689 (GRCm39)	Q160*	probably null	Het
Or11h6	T	A	14: 50,879,975 (GRCm39)		probably null	Het
Or2y1d	A	T	11: 49,321,859 (GRCm39)	K185N	probably damaging	Het
Or5w1b	T	A	2: 87,475,630 (GRCm39)	Y279F	probably damaging	Het
Or7e168	C	T	9: 19,720,343 (GRCm39)	S243F	probably damaging	Het
Or8c11	A	T	9: 38,289,542 (GRCm39)	T122S	probably damaging	Het
Or9q2	T	G	19: 13,772,693 (GRCm39)	Q94P	possibly damaging	Het
Pdgfrb	A	C	18: 61,213,404 (GRCm39)	Q916P	probably damaging	Het
Pex14	T	C	4: 149,050,743 (GRCm39)	Q174R	probably benign	Het
Pogz	T	C	3: 94,786,321 (GRCm39)	S970P	probably damaging	Het
Potegl	T	C	2: 23,102,667 (GRCm39)		probably benign	Het
Rabggta	A	G	14: 55,955,952 (GRCm39)	V165A	possibly damaging	Het
Rdh10	G	A	1: 16,176,438 (GRCm39)	W66*	probably null	Het
Ripor2	T	A	13: 24,879,549 (GRCm39)		probably benign	Het
Slc35g1	T	A	19: 38,391,678 (GRCm39)	M320K	possibly damaging	Het
Slc9a7	A	G	X: 20,068,963 (GRCm39)	Y197H	probably damaging	Het
Smn1	T	C	13: 100,272,192 (GRCm39)		probably benign	Het
Spam1	G	A	6: 24,796,696 (GRCm39)	G216S	probably damaging	Het
Spata31	A	T	13: 65,068,194 (GRCm39)	N114I	probably damaging	Het
Sptbn1	A	T	11: 30,069,491 (GRCm39)	V1615D	possibly damaging	Het
Srrm1	G	A	4: 135,052,415 (GRCm39)	P658L	unknown	Het
Thoc2	T	A	X: 40,914,355 (GRCm39)	Q1005H	possibly damaging	Het
Thra	G	A	11: 98,652,742 (GRCm39)	R189Q	probably damaging	Het
Trappc11	A	T	8: 47,983,685 (GRCm39)		probably null	Het
Vps13d	G	T	4: 144,882,934 (GRCm39)	H886Q	probably damaging	Het

Other mutations in Zfp157

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01322:Zfp157	APN	5	138,445,840 (GRCm39)	missense	probably benign	0.02
R1476:Zfp157	UTSW	5	138,453,357 (GRCm39)	critical splice donor site	probably null
R1883:Zfp157	UTSW	5	138,443,102 (GRCm39)	missense	probably damaging	1.00
R1884:Zfp157	UTSW	5	138,443,102 (GRCm39)	missense	probably damaging	1.00
R3401:Zfp157	UTSW	5	138,455,273 (GRCm39)	missense	probably benign	0.35
R4237:Zfp157	UTSW	5	138,445,803 (GRCm39)	missense	probably damaging	1.00
R4239:Zfp157	UTSW	5	138,445,803 (GRCm39)	missense	probably damaging	1.00
R4573:Zfp157	UTSW	5	138,455,191 (GRCm39)	missense	probably damaging	0.97
R4785:Zfp157	UTSW	5	138,443,051 (GRCm39)	missense	probably damaging	1.00
R4914:Zfp157	UTSW	5	138,454,557 (GRCm39)	missense	possibly damaging	0.85
R5476:Zfp157	UTSW	5	138,455,443 (GRCm39)	missense	possibly damaging	0.92
R6128:Zfp157	UTSW	5	138,453,281 (GRCm39)	missense	possibly damaging	0.95
R6473:Zfp157	UTSW	5	138,454,188 (GRCm39)	missense	probably damaging	0.99
R6572:Zfp157	UTSW	5	138,455,313 (GRCm39)	missense	possibly damaging	0.92
R6990:Zfp157	UTSW	5	138,454,772 (GRCm39)	nonsense	probably null
R7638:Zfp157	UTSW	5	138,454,172 (GRCm39)	missense	probably benign	0.04
R7966:Zfp157	UTSW	5	138,445,833 (GRCm39)	missense	probably benign	0.14
R7994:Zfp157	UTSW	5	138,453,450 (GRCm39)	splice site	probably null
R8057:Zfp157	UTSW	5	138,454,336 (GRCm39)	missense	probably damaging	1.00
R8397:Zfp157	UTSW	5	138,454,518 (GRCm39)	missense	probably damaging	1.00
Z1088:Zfp157	UTSW	5	138,455,461 (GRCm39)	missense	probably damaging	0.98

Posted On

2015-04-16