Incidental Mutation 'IGL02382:Or8d1'
ID 291406
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or8d1
Ensembl Gene ENSMUSG00000047667
Gene Name olfactory receptor family 8 subfamily D member 1
Synonyms GA_x6K02T2PVTD-32550930-32551856, MOR171-9, MTPCR09, Olfr26
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # IGL02382
Quality Score
Chromosome 9
Chromosomal Location 38766356-38767286 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 38766364 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Aspartic acid at position 2 (G2D)
Ref Sequence ENSEMBL: ENSMUSP00000100467 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000104874] [ENSMUST00000217350]
AlphaFold Q7TRB7
Predicted Effect probably benign
Transcript: ENSMUST00000104874
AA Change: G2D

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000100467
Gene: ENSMUSG00000047667
AA Change: G2D

Pfam:7tm_4 31 308 3.8e-49 PFAM
Pfam:7tm_1 41 290 2.4e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217350
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aim2 A G 1: 173,287,315 (GRCm39) probably null Het
Aoc2 T C 11: 101,217,498 (GRCm39) L527P probably damaging Het
Arhgef15 C A 11: 68,844,856 (GRCm39) R247L probably damaging Het
Armcx2 T C X: 133,706,416 (GRCm39) T406A probably benign Het
Armcx5 T C X: 134,647,577 (GRCm39) F551S probably damaging Het
Ccrl2 T C 9: 110,884,947 (GRCm39) K184E probably benign Het
Cenpe A G 3: 134,953,147 (GRCm39) I1534V probably benign Het
Cflar T A 1: 58,791,840 (GRCm39) I381K probably benign Het
Crb1 T A 1: 139,165,352 (GRCm39) N924I probably damaging Het
Crebbp A G 16: 3,925,934 (GRCm39) V729A probably damaging Het
Dab2 T A 15: 6,466,468 (GRCm39) V615D possibly damaging Het
Edrf1 T C 7: 133,252,344 (GRCm39) probably benign Het
Ep400 G A 5: 110,849,594 (GRCm39) T1409I unknown Het
Gm14406 C A 2: 177,260,988 (GRCm39) probably benign Het
Kptn T A 7: 15,857,945 (GRCm39) S258T probably benign Het
Mbnl1 G T 3: 60,532,563 (GRCm39) E291* probably null Het
Mcm4 A T 16: 15,442,602 (GRCm39) L843Q probably damaging Het
Mgrn1 A G 16: 4,740,482 (GRCm39) N274D probably damaging Het
Or13a21 T A 7: 139,999,516 (GRCm39) T57S possibly damaging Het
Phactr4 A T 4: 132,098,152 (GRCm39) V335E probably damaging Het
Ptgr2 T C 12: 84,360,722 (GRCm39) S331P probably damaging Het
Ranbp9 T C 13: 43,589,622 (GRCm39) probably null Het
Setd5 A G 6: 113,120,601 (GRCm39) T937A probably benign Het
Slc27a4 C T 2: 29,699,855 (GRCm39) R265C probably damaging Het
Srrm1 G A 4: 135,052,415 (GRCm39) P658L unknown Het
Tenm3 A G 8: 48,688,511 (GRCm39) Y2359H probably damaging Het
Tnip3 T C 6: 65,591,779 (GRCm39) probably null Het
Zfc3h1 C T 10: 115,252,781 (GRCm39) Q1365* probably null Het
Other mutations in Or8d1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01518:Or8d1 APN 9 38,767,095 (GRCm39) missense probably benign 0.00
IGL01909:Or8d1 APN 9 38,767,013 (GRCm39) nonsense probably null
IGL02146:Or8d1 APN 9 38,766,654 (GRCm39) missense probably benign 0.01
IGL02229:Or8d1 APN 9 38,766,712 (GRCm39) missense possibly damaging 0.62
IGL03007:Or8d1 APN 9 38,766,592 (GRCm39) missense probably damaging 1.00
IGL03118:Or8d1 APN 9 38,766,526 (GRCm39) missense probably damaging 1.00
PIT4403001:Or8d1 UTSW 9 38,766,676 (GRCm39) missense probably benign 0.39
R0590:Or8d1 UTSW 9 38,766,766 (GRCm39) missense probably damaging 0.99
R0862:Or8d1 UTSW 9 38,766,478 (GRCm39) missense possibly damaging 0.89
R1779:Or8d1 UTSW 9 38,766,846 (GRCm39) missense possibly damaging 0.55
R1796:Or8d1 UTSW 9 38,766,820 (GRCm39) missense probably benign 0.01
R2083:Or8d1 UTSW 9 38,766,637 (GRCm39) missense probably benign 0.10
R3420:Or8d1 UTSW 9 38,766,621 (GRCm39) missense possibly damaging 0.92
R3421:Or8d1 UTSW 9 38,766,621 (GRCm39) missense possibly damaging 0.92
R4328:Or8d1 UTSW 9 38,767,132 (GRCm39) missense possibly damaging 0.62
R4470:Or8d1 UTSW 9 38,766,927 (GRCm39) missense probably damaging 1.00
R4471:Or8d1 UTSW 9 38,766,927 (GRCm39) missense probably damaging 1.00
R5047:Or8d1 UTSW 9 38,766,585 (GRCm39) missense probably benign 0.36
R5267:Or8d1 UTSW 9 38,767,101 (GRCm39) missense probably damaging 1.00
R5318:Or8d1 UTSW 9 38,766,744 (GRCm39) missense probably damaging 1.00
R6502:Or8d1 UTSW 9 38,766,933 (GRCm39) missense probably damaging 0.99
R7221:Or8d1 UTSW 9 38,766,538 (GRCm39) missense probably damaging 1.00
R7297:Or8d1 UTSW 9 38,767,245 (GRCm39) missense probably damaging 1.00
R7448:Or8d1 UTSW 9 38,766,412 (GRCm39) missense probably damaging 1.00
R7525:Or8d1 UTSW 9 38,766,534 (GRCm39) missense possibly damaging 0.89
R8040:Or8d1 UTSW 9 38,766,460 (GRCm39) missense probably damaging 0.99
R8303:Or8d1 UTSW 9 38,766,837 (GRCm39) missense probably damaging 1.00
R8972:Or8d1 UTSW 9 38,767,254 (GRCm39) missense probably damaging 1.00
Z1177:Or8d1 UTSW 9 38,766,531 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16