Incidental Mutation 'IGL02382:Tnip3'
ID291427
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tnip3
Ensembl Gene ENSMUSG00000044162
Gene NameTNFAIP3 interacting protein 3
Synonyms
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02382
Quality Score
Status
Chromosome6
Chromosomal Location65525313-65634040 bp(+) (GRCm38)
Type of Mutationcritical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to C at 65614795 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000148446 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000114236] [ENSMUST00000212375] [ENSMUST00000212402]
Predicted Effect probably null
Transcript: ENSMUST00000114236
SMART Domains Protein: ENSMUSP00000109874
Gene: ENSMUSG00000044162

DomainStartEndE-ValueType
coiled coil region 20 145 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000212375
Predicted Effect probably null
Transcript: ENSMUST00000212402
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile and do not develop spontaneous inflammatory or autoimmune disease; mutant macrophages exhibit normal responses to IL-10 and LPS. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aim2 A G 1: 173,459,749 probably null Het
Aoc2 T C 11: 101,326,672 L527P probably damaging Het
Arhgef15 C A 11: 68,954,030 R247L probably damaging Het
Armcx2 T C X: 134,805,667 T406A probably benign Het
Armcx5 T C X: 135,746,828 F551S probably damaging Het
Ccrl2 T C 9: 111,055,879 K184E probably benign Het
Cenpe A G 3: 135,247,386 I1534V probably benign Het
Cflar T A 1: 58,752,681 I381K probably benign Het
Crb1 T A 1: 139,237,614 N924I probably damaging Het
Crebbp A G 16: 4,108,070 V729A probably damaging Het
Dab2 T A 15: 6,436,987 V615D possibly damaging Het
Edrf1 T C 7: 133,650,615 probably benign Het
Ep400 G A 5: 110,701,728 T1409I unknown Het
Gm14406 C A 2: 177,569,195 probably benign Het
Kptn T A 7: 16,124,020 S258T probably benign Het
Mbnl1 G T 3: 60,625,142 E291* probably null Het
Mcm4 A T 16: 15,624,738 L843Q probably damaging Het
Mgrn1 A G 16: 4,922,618 N274D probably damaging Het
Olfr26 G A 9: 38,855,068 G2D probably benign Het
Olfr532 T A 7: 140,419,603 T57S possibly damaging Het
Phactr4 A T 4: 132,370,841 V335E probably damaging Het
Ptgr2 T C 12: 84,313,948 S331P probably damaging Het
Ranbp9 T C 13: 43,436,146 probably null Het
Setd5 A G 6: 113,143,640 T937A probably benign Het
Slc27a4 C T 2: 29,809,843 R265C probably damaging Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Tenm3 A G 8: 48,235,476 Y2359H probably damaging Het
Zfc3h1 C T 10: 115,416,876 Q1365* probably null Het
Other mutations in Tnip3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01736:Tnip3 APN 6 65596123 splice site probably benign
IGL02054:Tnip3 APN 6 65590611 missense possibly damaging 0.72
R0671:Tnip3 UTSW 6 65597363 missense probably damaging 1.00
R1344:Tnip3 UTSW 6 65597429 missense probably benign 0.44
R1418:Tnip3 UTSW 6 65597429 missense probably benign 0.44
R3748:Tnip3 UTSW 6 65614763 missense probably damaging 0.99
R3953:Tnip3 UTSW 6 65597395 missense possibly damaging 0.48
R3955:Tnip3 UTSW 6 65597395 missense possibly damaging 0.48
R5775:Tnip3 UTSW 6 65614757 missense probably benign 0.01
R5930:Tnip3 UTSW 6 65605953 missense probably damaging 1.00
R6108:Tnip3 UTSW 6 65525411 splice site probably null
R6495:Tnip3 UTSW 6 65605862 missense probably benign 0.05
R7210:Tnip3 UTSW 6 65593511 nonsense probably null
R7956:Tnip3 UTSW 6 65614795 critical splice donor site probably null
R7983:Tnip3 UTSW 6 65538646 missense probably damaging 1.00
R8267:Tnip3 UTSW 6 65605842 missense possibly damaging 0.77
Z1177:Tnip3 UTSW 6 65614733 missense possibly damaging 0.90
Posted On2015-04-16